Molecular basis of tRNA recognition by the Elongator complex (2019)
Journal Article
Dauden, M. I., Jaciuk, M., Weis, F., Lin, T., Kleindienst, C., Abbassi, N. E. H., …Glatt, S. (2019). Molecular basis of tRNA recognition by the Elongator complex. Science Advances, 5(7), https://doi.org/10.1126/sciadv.aaw2326

The highly conserved Elongator complex modifies transfer RNAs (tRNAs) in their wobble base position, thereby regulating protein synthesis and ensuring proteome stability. The precise mechanisms of tRNA recognition and its modification reaction remain... Read More about Molecular basis of tRNA recognition by the Elongator complex.

The Elongator subunit Elp3 is a non-canonical tRNA acetyltransferase (2019)
Journal Article
Lin, T., Abbassi, N. E. H., Zakrzewski, K., Chramiec-Głąbik, A., Jemioła-Rzemińska, M., Różycki, J., & Glatt, S. (2019). The Elongator subunit Elp3 is a non-canonical tRNA acetyltransferase. Nature Communications, 10(1), https://doi.org/10.1038/s41467-019-08579-2

The Elongator complex catalyzes posttranscriptional tRNA modifications by attaching carboxy-methyl (cm5) moieties to uridine bases located in the wobble position. The catalytic subunit Elp3 is highly conserved and harbors two individual subdomains, a... Read More about The Elongator subunit Elp3 is a non-canonical tRNA acetyltransferase.