Platform-directed allostery and quaternary structure dynamics of SAMHD1 catalysis (2024)
Journal Article
Acton, O. J., Sheppard, D., Kunzelmann, S., Caswell, S. J., Nans, A., Burgess, A. J. O., …Taylor, I. A. (2024). Platform-directed allostery and quaternary structure dynamics of SAMHD1 catalysis. Nature Communications, 15(1), Article 3775. https://doi.org/10.1038/s41467-024-48237-w

SAMHD1 regulates cellular nucleotide homeostasis, controlling dNTP levels by catalysing their hydrolysis into 2’-deoxynucleosides and triphosphate. In differentiated CD4+ macrophage and resting T-cells SAMHD1 activity results in the inhibition of HIV... Read More about Platform-directed allostery and quaternary structure dynamics of SAMHD1 catalysis.