High thermal stability, pH responsive organogels of 2H-benzo[d]1,2,3-triazole derivatives as pharmaceutical crystallization media (2018)
Journal Article
Torres-Moya, I., Saikia, B., Prieto, P., Carrillo, J. R., & Steed, J. W. (2019). High thermal stability, pH responsive organogels of 2H-benzo[d]1,2,3-triazole derivatives as pharmaceutical crystallization media. CrystEngComm, 21(13), 2135-2143. https://doi.org/10.1039/c8ce01742e

2H-Benzo[d]1,2,3-triazole derivatives with a range of chemical functionalities showed significant organogel formation, particularly bis-amide derivative 4e which gave robust thermally stable gels, in a range of solvents down to 0.1 wt%. The gelators... Read More about High thermal stability, pH responsive organogels of 2H-benzo[d]1,2,3-triazole derivatives as pharmaceutical crystallization media.

Investigating the effect of supramolecular gel phase crystallization on gel nucleation (2018)
Journal Article
Dawn, A., Mirzamani, M., Jones, C. D., Yufit, D. S., Qian, S., Steed, J. W., & Kumari, H. (2018). Investigating the effect of supramolecular gel phase crystallization on gel nucleation. Soft Matter, 14(46), 9489-9497. https://doi.org/10.1039/c8sm01916a

Supramolecular gel phase crystallization offers a new strategy for drug polymorph screening and discovery. In this method, the crystallization outcome depends on the interaction between solute and gel fibre. While supramolecular gels have shown succe... Read More about Investigating the effect of supramolecular gel phase crystallization on gel nucleation.

Supramolecular gelation as the first stage in Ostwald’s rule (2018)
Journal Article
Andrews, J. L., Pearson, E., Yufit, D. S., Steed, J. W., & Edkins, K. (2018). Supramolecular gelation as the first stage in Ostwald’s rule. Crystal Growth and Design, 18(12), 7690-7700. https://doi.org/10.1021/acs.cgd.8b01539

Ostwald’s rule of stages describes the observation that a metastable polymorph of a particular compound will crystallise before the thermodynamically stable form under the same conditions. Whilst traditionally applied to crystalline systems, there ha... Read More about Supramolecular gelation as the first stage in Ostwald’s rule.

21st Century Developments in the Understanding and Control of Molecular Solids (2018)
Journal Article
Steed, J. W. (2018). 21st Century Developments in the Understanding and Control of Molecular Solids. Chemical Communications, 54(94), 13175-13182. https://doi.org/10.1039/c8cc08277d

The first decades of the 21st Century have seen very significant advances in the understanding, prediction and control of molecular solids. Advances in crystallization techniques, polymorphism, co-crystals, co-amorphous materials, crystal engineering... Read More about 21st Century Developments in the Understanding and Control of Molecular Solids.

Crystal habit modification of Cu(ii) isonicotinate–N-oxide complexes using gel phase crystallisation (2018)
Journal Article
Ghosh, D., Ferfolja, K., Drabavičius, Ž., Steed, J. W., & Damodaran, K. K. (2018). Crystal habit modification of Cu(ii) isonicotinate–N-oxide complexes using gel phase crystallisation. New Journal of Chemistry, 42(24), 19963-19970. https://doi.org/10.1039/c8nj05036h

We report the crystallisation of three forms of the copper(II) isonicotinate–N-oxide complex and their phase interconversion via solvent-mediated crystal-to-crystal transformation. The different forms of the copper complex have been isolated and char... Read More about Crystal habit modification of Cu(ii) isonicotinate–N-oxide complexes using gel phase crystallisation.

Structures of a Clathrate Hydrate Former, Inhibitor, and Synergist in Water (2018)
Journal Article
Perrin, A., Goodwin, M. J., Callear, S., Soper, A. K., Musa, O. M., & Steed, J. W. (2018). Structures of a Clathrate Hydrate Former, Inhibitor, and Synergist in Water. Journal of Physical Chemistry B (Soft Condensed Matter and Biophysical Chemistry), 122(18), 4901-4912. https://doi.org/10.1021/acs.jpcb.8b02762

SANS studies are reported for aqueous THF at the 1:17 clathrate hydrate-forming composition and on aqueous solutions of the synergist 2-butoxyethanol. Addition of the clathrate hydrate inhibitor polyvinylcaprolactam and a dimeric model compound, 1,3-... Read More about Structures of a Clathrate Hydrate Former, Inhibitor, and Synergist in Water.

Dynamic behaviour in nicotinate-bridged binuclear ruthenium(IV) complexes (2018)
Journal Article
Steed, J. W., & Tocher, D. A. (2018). Dynamic behaviour in nicotinate-bridged binuclear ruthenium(IV) complexes. Polyhedron, 147, 152-155. https://doi.org/10.1016/j.poly.2018.03.025

The isonicotinic acid adduct [Ru(η3:η3-C10H16)Cl2(p-NC5H4CO2H)] 1 and nicotinate and isonicotinate bridged binuclear complexes [Ru2(η3:η3-C10H16)2Cl3(μ-κN,O,O′-NC5H4CO2)] 2 and 3 are reported. Complexes 2 and 3 exist as mixtures of diastereoisomers a... Read More about Dynamic behaviour in nicotinate-bridged binuclear ruthenium(IV) complexes.

Activating [4+4] photoreactivity in the solid-state via complexation: from 9-(methylaminomethyl)anthracene to its silver(I) complexes (2018)
Journal Article
Spinelli, F., d'Agostino, S., Taddei, P., Jones, C. D., Steed, J. W., & Grepioni, F. (2018). Activating [4+4] photoreactivity in the solid-state via complexation: from 9-(methylaminomethyl)anthracene to its silver(I) complexes. Dalton Transactions, 16(47), 5725-5733. https://doi.org/10.1039/c8dt00198g

The [4 + 4] photoreactivity of the anthracene derivative 9-(methylaminomethyl)anthracene (MAMA) has been investigated in solution, gel medium and in the solid state. While quantitative formation of the cyloaddition photoproduct was achieved upon irra... Read More about Activating [4+4] photoreactivity in the solid-state via complexation: from 9-(methylaminomethyl)anthracene to its silver(I) complexes.

Tailored Supramolecular Gel and Microemulsion Crystallization Strategies – is Isoniazid Really Monomorphic? (2018)
Journal Article
Kennedy, S. R., Jones, C. D., Yufit, D. S., Nicholson, C. E., Cooper, S. J., & Steed, J. W. (2018). Tailored Supramolecular Gel and Microemulsion Crystallization Strategies – is Isoniazid Really Monomorphic?. CrystEngComm, 20(10), 1390-1398. https://doi.org/10.1039/c8ce00066b

We report the application of supramolecular gel and microemulsion droplet crystallisation methodologies to isoniazid crystallization. Tailored gelators have been designed with isoniazid mimetic functionality in an attempt to control crystal morpholog... Read More about Tailored Supramolecular Gel and Microemulsion Crystallization Strategies – is Isoniazid Really Monomorphic?.

Phosphate-Free Inhibition of Calcium Carbonate Dishwasher Deposits (2018)
Journal Article
Hong, Y., Letzelter, N., Evans, J. S., Yufit, D. S., & Steed, J. W. (2018). Phosphate-Free Inhibition of Calcium Carbonate Dishwasher Deposits. Crystal Growth and Design, 18(3), 1526-1538. https://doi.org/10.1021/acs.cgd.7b01508

This paper reports the characterization of the composition and morphology of mineral formation on glass and plastic (polymethylmethacrylate) substrates in a dishwasher environment and the identification of suitable phosphate-free mineral crystallizat... Read More about Phosphate-Free Inhibition of Calcium Carbonate Dishwasher Deposits.

Small-Molecule Povidone Analogs in Coamorphous Pharmaceutical Phases (2018)
Journal Article
Goodwin, M., Musa, O., Berry, D., & Steed, J. W. (2018). Small-Molecule Povidone Analogs in Coamorphous Pharmaceutical Phases. Crystal Growth and Design, 18(2), 701-709. https://doi.org/10.1021/acs.cgd.7b01062

The crystallization inhibitor polyvinylpyrrolidone (PVP) is commonly used as a stabilizer in the formation of amorphous polymer dispersions of poorly soluble pharmaceuticals. In this work we examine the use of a range of PVP-inspired small-molecule b... Read More about Small-Molecule Povidone Analogs in Coamorphous Pharmaceutical Phases.