The accumulation of un-repairable DNA damage in laminopathy progeria fibroblasts is caused by ROS generation and is prevented by treatment with N-acetyl cysteine (2011)
Journal Article
Richards, S., Muter, J., Ritchie, P., Lattanzi, G., & Hutchison, C. (2011). The accumulation of un-repairable DNA damage in laminopathy progeria fibroblasts is caused by ROS generation and is prevented by treatment with N-acetyl cysteine. Human Molecular Genetics, 20(20), 3997-4004. https://doi.org/10.1093/hmg/ddr327

Fibroblasts from patients with the severe laminopathy diseases, Restrictive Dermopathy (RD) & Hutchinson Gilford Progeria Syndrome (HGPS), are characterised by poor growth in culture, the presence of abnormally shaped nuclei and the accumulation of D... Read More about The accumulation of un-repairable DNA damage in laminopathy progeria fibroblasts is caused by ROS generation and is prevented by treatment with N-acetyl cysteine.