The inner nuclear membrane protein Emerin regulates beta-catenin activity by restricting its accumulation in the nucleus (2006)
Journal Article
Markiewicz, E., Tilgner, K., Barker, N., van de Wetering, M., Clevers, H., Dorobek, M., …Hutchison, C. (2006). The inner nuclear membrane protein Emerin regulates beta-catenin activity by restricting its accumulation in the nucleus. The EMBO Journal, 25(14), 3275-3285. https://doi.org/10.1038/sj.emboj.7601230

Emerin is a type II inner nuclear membrane (INM) protein of unknown function. Emerin function is likely to be important because, when it is mutated, emerin promotes both skeletal muscle and heart defects. Here we show that one function of Emerin is t... Read More about The inner nuclear membrane protein Emerin regulates beta-catenin activity by restricting its accumulation in the nucleus.

Lamina-associated polypeptide 2 alpha regulates cell cycle progression and differentiation via the retinoblastoma-E2F pathway (2006)
Journal Article
Dorner, D., Vlcek, S., Foeger, N., Gajewski, A., Makolm, C., Gotzmann, J., …Foisner, R. (2006). Lamina-associated polypeptide 2 alpha regulates cell cycle progression and differentiation via the retinoblastoma-E2F pathway. Journal of Cell Biology, 173(1), 83-93. https://doi.org/10.1083/jcb.200511149

Lamina-associated polypeptide (LAP) 2 is a nonmembrane-bound LAP2 isoform that forms complexes with nucleoplasmic A-type lamins. In this study, we show that the overexpression of LAP2 in fibroblasts reduced proliferation and delayed entry into the ce... Read More about Lamina-associated polypeptide 2 alpha regulates cell cycle progression and differentiation via the retinoblastoma-E2F pathway.