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Endocytosis and sphingolipid scavenging in Leishmania mexicana amastigotes (2011)
Journal Article
Ali, H., Harding, C., & Denny, P. (2012). Endocytosis and sphingolipid scavenging in Leishmania mexicana amastigotes. Biochemistry Research International, 2012, Article 691363. https://doi.org/10.1155/2012/691363

Leishmania species are the causative agents of the leishmaniases, a spectrum of neglected tropical diseases. Amastigote stage parasites exist within macrophages and scavenge host factors for survival, for example, Leishmania species utilise host sphi... Read More about Endocytosis and sphingolipid scavenging in Leishmania mexicana amastigotes.

Studies on the antileishmanial properties of the antimicrobial peptides temporin A, B and 1Sa (2011)
Journal Article
Chadbourne, F., Raleigh, C., Ali, H., Denny, P., & Cobb, S. (2011). Studies on the antileishmanial properties of the antimicrobial peptides temporin A, B and 1Sa. Journal of Peptide Science, 17(11), 751-755. https://doi.org/10.1002/psc.1398

Given the paucity and toxicity of available drugs for leishmaniasis, coupled with the advent of drug resistance, the discovery of new therapies for this neglected tropical disease is recognised as being of the utmost urgency. As such antimicrobial pe... Read More about Studies on the antileishmanial properties of the antimicrobial peptides temporin A, B and 1Sa.

Evidence for the assembly of a bacterial tripartite multidrug pump with a stoichiometry of 3:6:3 (2011)
Journal Article
Janganan, T., Bavro, V., Zhang, L., Matak-Vinkovic, D., Barrera, N., Venien-Bryan, C., …Walmsley, A. (2011). Evidence for the assembly of a bacterial tripartite multidrug pump with a stoichiometry of 3:6:3. Journal of Biological Chemistry, 286(30), 26900-26912. https://doi.org/10.1074/jbc.m111.246595

The multiple transferable resistance (mTR) pump from Neisseria gonorrhoeae MtrCDE multidrug pump is assembled from the inner and outer membrane proteins MtrD and MtrE and the periplasmic membrane fusion protein MtrC. Previously we established that wh... Read More about Evidence for the assembly of a bacterial tripartite multidrug pump with a stoichiometry of 3:6:3.

Opening of the Outer Membrane Protein Channel in Tripartite Efflux Pumps Is Induced by Interaction with the Membrane Fusion Partner (2011)
Journal Article
Janganan, T., Zhang, L., Bavro, V., Matak-Vinkovic, D., Barrera, N., Burton, M., …Walmsley, A. (2011). Opening of the Outer Membrane Protein Channel in Tripartite Efflux Pumps Is Induced by Interaction with the Membrane Fusion Partner. Journal of Biological Chemistry, 286(7), 5484-5493. https://doi.org/10.1074/jbc.m110.187658

The multiple transferable resistance (MTR) pump, from Neisseria gonorrhoeae, is typical of the specialized machinery used to translocate drugs across the inner and outer membranes of Gram-negative bacteria. It consists of a tripartite complex compose... Read More about Opening of the Outer Membrane Protein Channel in Tripartite Efflux Pumps Is Induced by Interaction with the Membrane Fusion Partner.

Exploring Leishmania major inositol phosphorylceramide synthase (LmjIPCS): insights into the ceramide binding domain (2011)
Journal Article
Mina, J., Mosely, J., Ali, H., Denny, P., & Steel, P. (2011). Exploring Leishmania major inositol phosphorylceramide synthase (LmjIPCS): insights into the ceramide binding domain. Organic and Biomolecular Chemistry, 9(6), 1823-1830. https://doi.org/10.1039/c0ob00871k

The synthesis of set of ceramide analogues exploring hydrophobicity in the acyl chains and the degree and nature of hydroxylation is described. These have been assayed against the parasitic protozoan enzyme LmjIPCS. These studies showed that whilst t... Read More about Exploring Leishmania major inositol phosphorylceramide synthase (LmjIPCS): insights into the ceramide binding domain.

Influence of Lipids on the Interfacial Disposition of Respiratory Syncytical Virus Matrix Protein (2011)
Journal Article
McPhee, H., Carlisle, J., Beeby, A., Money, V., Watson, M., Yeo, R., & Sanderson, J. (2011). Influence of Lipids on the Interfacial Disposition of Respiratory Syncytical Virus Matrix Protein. Langmuir, 27(1), 304-311. https://doi.org/10.1021/la104041n

The propensity of a matrix protein from an enveloped virus of the Mononegavirales family to associate with lipids representative of the viral envelope has been determined using label-free methods, including tensiometry and Brewster angle microscopy o... Read More about Influence of Lipids on the Interfacial Disposition of Respiratory Syncytical Virus Matrix Protein.