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An arsenic metallochaperone for an arsenic detoxification pump (2006)
Journal Article
Lin, Y., Walmsley, A. R., & Rosen, B. P. (2006). An arsenic metallochaperone for an arsenic detoxification pump. Proceedings of the National Academy of Sciences, 103(42), 15617-15622. https://doi.org/10.1073/pnas.0603974103

Environmental arsenic is a world-wide health issue, making it imperative for us to understand mechanisms of metalloid uptake and detoxification. The predominant intracellular form is the highly mephitic arsenite, which is detoxified by removal from c... Read More about An arsenic metallochaperone for an arsenic detoxification pump.

Synthesis and SAR study of acridine, 2-methylquinoline and 2-phenylquinazoline analogues as anti-prion agents (2006)
Journal Article
Cope, H., Mutter, R., Heal, W., Pascoe, C., Brown, P., Pratt, S., & Chen, B. (2006). Synthesis and SAR study of acridine, 2-methylquinoline and 2-phenylquinazoline analogues as anti-prion agents. European Journal of Medicinal Chemistry, 41(10), 1124-1143. https://doi.org/10.1016/j.ejmech.2006.05.002

Transmissible spongiform encephalopathies (TSEs) are thought to arise from aggregation of a protease resistant protein denoted PrPSc, which is a misfolded isoform of the normal cellular prion protein PrPC. Using virtual high-throughput screening we h... Read More about Synthesis and SAR study of acridine, 2-methylquinoline and 2-phenylquinazoline analogues as anti-prion agents.

The protozoan inositol phosphorylceramide synthase: A novel drug target that defines a new class of sphingolipid synthase (2006)
Journal Article
Denny, P., Shams-Eldin, H., Price, H., Smith, D., & Schwarz, R. (2006). The protozoan inositol phosphorylceramide synthase: A novel drug target that defines a new class of sphingolipid synthase. Journal of Biological Chemistry, 281(38), 28200-28209. https://doi.org/10.1074/jbc.m600796200

Sphingolipids are ubiquitous and essential components of eukaryotic membranes, particularly the plasma membrane. The biosynthetic pathway for the formation of these lipid species is conserved up to the formation of sphinganine. However, a divergence... Read More about The protozoan inositol phosphorylceramide synthase: A novel drug target that defines a new class of sphingolipid synthase.

Phenotypic anchoring of arsenic and cadmium toxicity in three hepatic-related cell systems reveals compound- and cell-specific selective up-regulation of stress protein expression: implications for fingerprint profiling of cytotoxicity (2006)
Journal Article
Gottschalg, E., Moore, N., Ryan, A., Travis, L., Waller, R., Pratt, S., …Fry, J. (2006). Phenotypic anchoring of arsenic and cadmium toxicity in three hepatic-related cell systems reveals compound- and cell-specific selective up-regulation of stress protein expression: implications for fingerprint profiling of cytotoxicity. Chemico-Biological Interactions: A journal of molecular, cellular and biochemical toxicology, 161(3), 251-261. https://doi.org/10.1016/j.cbi.2006.04.003

Exposure of cells to toxic chemicals is known to up-regulate the expression of a number of stress proteins (SPs), including metallothionein (MT) and members of the heat shock protein (HSP) family, and this response may allow the development of a fing... Read More about Phenotypic anchoring of arsenic and cadmium toxicity in three hepatic-related cell systems reveals compound- and cell-specific selective up-regulation of stress protein expression: implications for fingerprint profiling of cytotoxicity.

Novel antibiotics: C-2 symmetrical macrocycles inhibiting Holliday junction DNA binding by E. coli RuvC. (2006)
Journal Article
Pan, P., Curtis, F., Carroll, C., Medina, I., Rodrigeuz, R., Liotta, L., …McAlpine, S. (2006). Novel antibiotics: C-2 symmetrical macrocycles inhibiting Holliday junction DNA binding by E. coli RuvC. Bioorganic and Medicinal Chemistry, 14(14), 4731-4739. https://doi.org/10.1016/j.bmc.2006.03.028

Holliday junctions (HJs) are formed as transient DNA intermediates during site-specific and homologous recombination. Both of these genetic exchange pathways are critical for normal DNA metabolism and repair. Trapping HJs leads to bacterial cell deat... Read More about Novel antibiotics: C-2 symmetrical macrocycles inhibiting Holliday junction DNA binding by E. coli RuvC..

Screening a Library of Potential Prion Therapeutics against Cellular Prion Proteins and Insights into their Mode of Biological Activities by Surface Plasmon Resonance (2006)
Journal Article
Touil, F., Pratt, S., Mutter, R., & Chen, B. (2006). Screening a Library of Potential Prion Therapeutics against Cellular Prion Proteins and Insights into their Mode of Biological Activities by Surface Plasmon Resonance. Journal of Pharmaceutical and Biomedical Analysis, 40(3), 822-832. https://doi.org/10.1016/j.jpba.2005.08.011

The conversion of cellular prion protein (PrPC) to the protease resistant isoform (PrPSc) is considered essential for the progression of transmissible spongiform encephalopathies (TSEs). A potential therapeutic strategy for preventing the accumulatio... Read More about Screening a Library of Potential Prion Therapeutics against Cellular Prion Proteins and Insights into their Mode of Biological Activities by Surface Plasmon Resonance.

Library Design, Synthesis And Screening: Pyridine Dicarbonitriles As Potential Prion Disease Therapeutics (2006)
Journal Article
Reddy, T., Mutter, R., Heal, W., Guo, K., Pratt, S., Gillet, V., & Chen, B. (2006). Library Design, Synthesis And Screening: Pyridine Dicarbonitriles As Potential Prion Disease Therapeutics. Journal of Medicinal Chemistry, 49(2), 607-615. https://doi.org/10.1021/jm050610f

Transmissible spongiform encephalopathies (TSEs) or prion diseases are a family of invariably fatal neurodegenerative disorders, and there are no effective therapeutics currently available. In this paper, we report on the design, synthesis, and scree... Read More about Library Design, Synthesis And Screening: Pyridine Dicarbonitriles As Potential Prion Disease Therapeutics.