Novel antibiotics: second generation macrocyclic peptides designed to trap Holliday junctions. (2004)
Journal Article
Liotta, L., Medina, I., Robinson, J., Carroll, C., Pan, P., Corral, R., …McAlpine, S. (2004). Novel antibiotics: second generation macrocyclic peptides designed to trap Holliday junctions. Tetrahedron Letters, 45, 8447-8450. https://doi.org/10.1016/j.tetlet.2004.09.084

Described are the syntheses of 15 macrocyclic peptides designed to trap Holliday junctions(HJs) in bacteria during site-specific and homologous recombination. This leads to inhibiting bacterial growth. These second generation macrocycles were based o... Read More about Novel antibiotics: second generation macrocyclic peptides designed to trap Holliday junctions..

Rafts and sphingolipid biosynthesis in the kinetoplastid parasitic protozoa (2004)
Journal Article
Denny, P., & Smith, D. (2004). Rafts and sphingolipid biosynthesis in the kinetoplastid parasitic protozoa. Molecular Microbiology, 53(3), 725-733. https://doi.org/10.1111/j.1365-2958.2004.04208.x

Although the concept of eukaryotic lipid rafts arouses controversy, recent biophysical studies strongly indicate that inducible, stable and relatively large rafts are a feature of activated mammalian cells. These studies allow us to consider the func... Read More about Rafts and sphingolipid biosynthesis in the kinetoplastid parasitic protozoa.

Holliday Junction Binding and Resolution by the Rap Structure-specific Endonuclease of Phage lambda (2004)
Journal Article
Sharples, G., Curtis, F., McGlynn, P., & Bolt, E. (2004). Holliday Junction Binding and Resolution by the Rap Structure-specific Endonuclease of Phage lambda. Journal of Molecular Biology, 340(4), 739-751. https://doi.org/10.1016/j.jmb.2004.05.030

Rap endonuclease targets recombinant joint molecules arising from phage lambda Red-mediated genetic exchange. Previous studies revealed that Rap nicks DNA at the branch point of synthetic Holliday junctions and other DNA structures with a branched co... Read More about Holliday Junction Binding and Resolution by the Rap Structure-specific Endonuclease of Phage lambda.

Conformational Flexibility in Recombinant Measles Virus Nucleocapsids Visualised by Cryo-negative Stain Electron Microscopy and Real-space Helical Reconstruction (2004)
Journal Article
Yeo, R., Bhella, D., & Ralph, A. (2004). Conformational Flexibility in Recombinant Measles Virus Nucleocapsids Visualised by Cryo-negative Stain Electron Microscopy and Real-space Helical Reconstruction. Journal of Molecular Biology, 340(2), 319-331. https://doi.org/10.1016/j.jmb.2004.05.015

Measles virus is a highly contagious virus that, despite the existence of an effective vaccine, is a major cause of illness and mortality worldwide. The virus has a negative-sense, single-stranded RNA genome that is encapsidated by the nucleocapsid p... Read More about Conformational Flexibility in Recombinant Measles Virus Nucleocapsids Visualised by Cryo-negative Stain Electron Microscopy and Real-space Helical Reconstruction.

DNA binding by the meningococcal RdgC protein associated with pilin antigenic variation (2004)
Journal Article
Moore, T., Sharples, G., & Lloyd, R. (2004). DNA binding by the meningococcal RdgC protein associated with pilin antigenic variation. Journal of Bacteriology, 186, 870-874

Heat Shock Protein Induction by Sodium Arsenite and Cadmium Chloride in Rat Hepatocytes and Rat FGC4 Hepatoma Cells (2004)
Journal Article
Pratt, S., Gottschalg, E., Atmaca, M., Kind, C., & Fry, J. (2004). Heat Shock Protein Induction by Sodium Arsenite and Cadmium Chloride in Rat Hepatocytes and Rat FGC4 Hepatoma Cells. Toxicology, 194(3), 235-236

Sphingolipid-free Leishmania are defective in membrane trafficking, differentiation and infectivity (2004)
Journal Article
Denny, P., Goulding, D., Ferguson, M., & Smith, D. (2004). Sphingolipid-free Leishmania are defective in membrane trafficking, differentiation and infectivity. Molecular Microbiology, 52(2), 313-327. https://doi.org/10.1111/j.1365-2958.2003.03975.x

Sphingolipids are structural components of the eukaryotic plasma membrane that are involved, together with cholesterol, in the formation of lipid microdomains (rafts). Additionally, sphingolipid metabolites have been shown to modulate a wide variety... Read More about Sphingolipid-free Leishmania are defective in membrane trafficking, differentiation and infectivity.