Outputs (3)

Structural and functional characterization of the extended-diKH domain from the antiviral endoribonuclease KHNYN (2025)
Journal Article
Youle, R. L., Lista, M. J., Bouton, C., Kunzelmann, S., Wilson, H., Cottee, M. A., Purkiss, A. G., Morris, E. R., Neil, S. J., Taylor, I. A., & Swanson, C. M. (online). Structural and functional characterization of the extended-diKH domain from the antiviral endoribonuclease KHNYN. Journal of Biological Chemistry, Article 108336. https://doi.org/10.1016/j.jbc.2025.108336

Zinc finger antiviral protein (ZAP) binds CpG dinucleotides in viral RNA and targets them for decay. ZAP interacts with several cofactors to form the ZAP antiviral system, including KHNYN, a multidomain endoribonuclease required for ZAP-mediated RNA... Read More about Structural and functional characterization of the extended-diKH domain from the antiviral endoribonuclease KHNYN.

Nanostructured lipid carrier for intracellular delivery of a bis(pyridine-2-carboxamidine) DNA minor groove binder active against Leishmania ACS Paragon Plus Environment (2025)
Journal Article
Martinez, N., Jonathan, J., & Denny, P. (in press). Nanostructured lipid carrier for intracellular delivery of a bis(pyridine-2-carboxamidine) DNA minor groove binder active against Leishmania ACS Paragon Plus Environment. ACS Omega,

A metal-trap tests and refines blueprints to engineer cellular protein metalation with different elements (2025)
Journal Article
Clough, S. E., Young, T. R., Tarrant, E., Scott, A. J. P., Chivers, P. T., Glasfeld, A., & Robinson, D. J. (2025). A metal-trap tests and refines blueprints to engineer cellular protein metalation with different elements. Nature Communications, 16(1), Article 810. https://doi.org/10.1038/s41467-025-56199-w

It has been challenging to test how proteins acquire specific metals in cells. The speciation of metalation is thought to depend on the preferences of proteins for different metals competing at intracellular metal-availabilities. This implies mis-met... Read More about A metal-trap tests and refines blueprints to engineer cellular protein metalation with different elements.