L55P transthyretin accelerates subunit exchange and leads to rapid formation of hybrid tetramers
(2005)
Journal Article
Keetch, C., Bromley, E., McCammon, M., Wang, N., Christodoulou, J., & Robinson, C. (2005). L55P transthyretin accelerates subunit exchange and leads to rapid formation of hybrid tetramers. Journal of Biological Chemistry, 280(50), 41667-41674
Transthyretin is a tetrameric protein associated with the commonest form of systemic amyloid disease. Using isotopically labeled proteins and mass spectrometry, we compared subunit exchange in wild-type transthyretin with that of the variant associat... Read More about L55P transthyretin accelerates subunit exchange and leads to rapid formation of hybrid tetramers.