Outputs (8)

The X philes: structure-specific endonucleases that resolve Holliday junctions. (2001)
Journal Article
Sharples, G. (2001). The X philes: structure-specific endonucleases that resolve Holliday junctions. Molecular Microbiology, 39, 823-834. https://doi.org/10.1046/j.1365-2958.2001.02284.x

Genetic recombination is a critical cellular process that promotes evolutionary diversity, facilitates DNA repair and underpins genome duplication. It entails the reciprocal exchange of single strands between homologous DNA duplexes to form a four-wa... Read More about The X philes: structure-specific endonucleases that resolve Holliday junctions..

Genetic analysis of an archaeal Holliday junction resolvase in Escherichia coli. (2001)
Journal Article
Bolt, E., Lloyd, R., & Sharples, G. (2001). Genetic analysis of an archaeal Holliday junction resolvase in Escherichia coli. Journal of Molecular Biology, 310(3), 577-589

The study of genes and proteins in heterologous model systems provides a powerful approach to the analysis of common processes in biology. Here, we show how the bacterium Escherichia coli can be exploited to analyse genetically and biochemically the... Read More about Genetic analysis of an archaeal Holliday junction resolvase in Escherichia coli..

Characterization of Monoclonal Antibodies raised against Recombinant Respiratory Syncytial Virus Nucleocapsid (N) Protein: Identification of a Region in the Carboxy Terminus of N Involved in the Interaction with P Protein (2001)
Journal Article
Murray, J., Loney, C., Murphy, L., Graham, S., & Yeo, R. (2001). Characterization of Monoclonal Antibodies raised against Recombinant Respiratory Syncytial Virus Nucleocapsid (N) Protein: Identification of a Region in the Carboxy Terminus of N Involved in the Interaction with P Protein. Virology, 289(2), 252-261. https://doi.org/10.1006/viro.2001.1150

To investigate structure and biological properties of the nucleocapsid (N) protein of respiratory syncytial virus (RSV), we have generated a panel of 16 monoclonal antibodies, raised against recombinant N protein, and epitope mapped seven of these to... Read More about Characterization of Monoclonal Antibodies raised against Recombinant Respiratory Syncytial Virus Nucleocapsid (N) Protein: Identification of a Region in the Carboxy Terminus of N Involved in the Interaction with P Protein.

Phenotypic changes associated with deletion and overexpression of a stage-regulated gene family in Leishmania (2001)
Journal Article
McKean, P., Denny, P., Knuepfer, E., Keen, J., & Smith, D. (2001). Phenotypic changes associated with deletion and overexpression of a stage-regulated gene family in Leishmania. Cellular Microbiology, 3(8), 511-523. https://doi.org/10.1046/j.1462-5822.2001.00135.x

The LmcDNA16 locus of Leishmania major contains three highly related genes HASPA1, HASPA2 and HASPB, encoding hydrophilic, acylated surface proteins and a tandem pair of unrelated sequences, SHERP1 and SHERP2, coding for a small, hydrophilic protein... Read More about Phenotypic changes associated with deletion and overexpression of a stage-regulated gene family in Leishmania.

Meeting Report: molecular Parasitology XI, Woods Hole, USA, September 17-21, 2000 (2001)
Journal Article
Denny, P., & Smith, D. (2001). Meeting Report: molecular Parasitology XI, Woods Hole, USA, September 17-21, 2000. Protist, 152(1), 3-6. https://doi.org/10.1078/1434-4610-00037

A kinetic model for the action of a resistance efflux pump (2001)
Journal Article
Walmsley, A., Zhou, T., Borges-Walmsley, M., & Rosen, B. (2001). A kinetic model for the action of a resistance efflux pump. Journal of Biological Chemistry, 276(9), 6378-6391. https://doi.org/10.1074/jbc.m008105200

ArsA is the catalytic subunit of the arsenical pump, coupling ATP hydrolysis to the efflux of arsenicals through the ArsB membrane protein. It is a paradigm for understanding the structure-function of the nucleotide binding domains (NBD) of medically... Read More about A kinetic model for the action of a resistance efflux pump.

GPI-anchored proteins and glycoconjugates segregate into lipid rafts in Kinetoplastida (2001)
Journal Article
Denny, P., Field, M., & Smith, D. (2001). GPI-anchored proteins and glycoconjugates segregate into lipid rafts in Kinetoplastida. FEBS Letters, 491(1-2), 148-153. https://doi.org/10.1016/s0014-5793%2801%2902172-x

The plasma membranes of the divergent eukaryotic parasites, Leishmania and Trypanosoma, are highly specialised, with a thick coat of glycoconjugates and glycoproteins playing a central role in virulence. Unusually, the majority of these surface macro... Read More about GPI-anchored proteins and glycoconjugates segregate into lipid rafts in Kinetoplastida.

The in vivo conformation of the Plastid DNA of Toxoplasma gondii: Implications for replication (2001)
Journal Article
Williamson, D., Denny, P., Moore, P., Sato, S., McCready, S., & Wilson, R. (2001). The in vivo conformation of the Plastid DNA of Toxoplasma gondii: Implications for replication. Journal of Molecular Biology, 306(2), 159-168. https://doi.org/10.1006/jmbi.2000.4385

The Phylum Apicomplexa comprises thousands of obligate intracellular parasites, some of which cause serious disease in man and other animals. Though not photosynthetic, some of them, including the malaria parasites (Plasmodium spp.) and the causative... Read More about The in vivo conformation of the Plastid DNA of Toxoplasma gondii: Implications for replication.