Outputs (5)

Haemophilus virulence. (1996)
Journal Article
Sharples, G. (1996). Haemophilus virulence. Microbiology, 142 ( Pt 4),

Holliday junction resolvases encoded by homologous rusA genes in Escherichia coli K-12 and phage 82. (1996)
Journal Article
Mahdi, A., Sharples, G., Mandal, T., & Lloyd, R. (1996). Holliday junction resolvases encoded by homologous rusA genes in Escherichia coli K-12 and phage 82

The RusA protein of Escherichia coli is an endonuclease that can resolve Holliday intermediates and correct the defects in genetic recombination and DNA repair associated with inactivation of RuvAB or RuvC. The structure of the rusA gene, its organis... Read More about Holliday junction resolvases encoded by homologous rusA genes in Escherichia coli K-12 and phage 82..

Crystal structure of DNA recombination protein RuvA and a model for its binding to the Holliday junction. (1996)
Journal Article
Rafferty, J., Sedelnikova, S., Hargreaves, D., Artymiuk, P., Baker, P., Sharples, G., …Rice, D. (1996). Crystal structure of DNA recombination protein RuvA and a model for its binding to the Holliday junction. Science, 274(5286), 415-421

The Escherichia coli DNA binding protein RuvA acts in concert with the helicase RuvB to drive branch migration of Holliday intermediates during recombination and DNA repair. The atomic structure of RuvA was determined at a resolution of 1.9 angstroms... Read More about Crystal structure of DNA recombination protein RuvA and a model for its binding to the Holliday junction..

The mmsA locus of Streptococcus pneumoniae encodes a RecG-like protein involved in DNA repair and in three-strand recombination. (1996)
Journal Article
Martin, B., Sharples, G., Humbert, O., Lloyd, R., & Claverys, J. (1996). The mmsA locus of Streptococcus pneumoniae encodes a RecG-like protein involved in DNA repair and in three-strand recombination. Molecular Microbiology, 19(5), 1035-1045

We describe the characterization of a mutant strain of Streptococcus pneumoniae previously isolated on the basis of its sensitivity to Methyl Methane Sulphonate (MMS). The mutant strain also exhibited increased sensitivity to UV light and to X-rays,... Read More about The mmsA locus of Streptococcus pneumoniae encodes a RecG-like protein involved in DNA repair and in three-strand recombination..

Recombination-dependent growth in exonuclease-depleted recBC sbcBC strains of Escherichia coli K-12. (1996)
Journal Article
Ryder, L., Sharples, G., & Lloyd, R. (1996). Recombination-dependent growth in exonuclease-depleted recBC sbcBC strains of Escherichia coli K-12. Genetics, 143(3), 1101-1114

Analysis of the aroLM-sbcCD interval of the Escherichia coli K-12 chromosome revealed a new gene (rdgC) encoding a function required for growth in recombination-deficient recBC sbcBC strains. Deletion of rdgC does not reduce viability, conjugational... Read More about Recombination-dependent growth in exonuclease-depleted recBC sbcBC strains of Escherichia coli K-12..