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Dr Alex Probert's Outputs (3)

A Catalytic Aldol Reaction and Condensation through In Situ Boron “Ate” Complex Enolate Generation in Water (2008)
Journal Article
Aelvoet, K., Batsanov, A. S., Blatch, A. J., Grosjean, C., Patrick, L. G. F., Smethurst, C. A., & Whiting, A. (2008). A Catalytic Aldol Reaction and Condensation through In Situ Boron “Ate” Complex Enolate Generation in Water. Angewandte Chemie International Edition, 47(4), 768-770. https://doi.org/10.1002/anie.200704293

Cooperation is key: N-Butyl-1-benzimidazole-2-phenylboronic acid hydroxide complex catalyzes the aldol condensation and aldol addition between hydroxyacetone or acetone, and different aldehydes in water. The catalytic activity results from cooperativ... Read More about A Catalytic Aldol Reaction and Condensation through In Situ Boron “Ate” Complex Enolate Generation in Water.

Benzimidazole Nitrogen-Directed, Regiocontrolled, Lithiation of Ferrocenyl- and Phenyl-N-n-butylbenzimidazoles (2006)
Journal Article
Herault, D., Aelvoet, K., Blatch, A. J., Al-Majid, A., Smethurst, C. A., & Whiting, A. (2007). Benzimidazole Nitrogen-Directed, Regiocontrolled, Lithiation of Ferrocenyl- and Phenyl-N-n-butylbenzimidazoles. Journal of Organic Chemistry, 72(1), 71-75. https://doi.org/10.1021/jo061639%2B

2-Ferrocenyl- and 2-phenyl-N-n-butylbenzimidazoles were synthesized to evaluate the influence of the benzimidazole functional group upon their directed lithiation. The regiochemistry of lithiation was studied, as well as the effect of stabilization o... Read More about Benzimidazole Nitrogen-Directed, Regiocontrolled, Lithiation of Ferrocenyl- and Phenyl-N-n-butylbenzimidazoles.

Synthesis and structure of bifunctional N-alkylbenzimidazole phenylboronate derivatives (2006)
Journal Article
Blatch, A. J., Chetina, O. V., Howard, J. A. K., Patrick, L. G. F., Smethurst, C. A., & Whiting, A. (2006). Synthesis and structure of bifunctional N-alkylbenzimidazole phenylboronate derivatives. Organic and Biomolecular Chemistry, 4(17), 3297-3302. https://doi.org/10.1039/B607127A

-Methyl and --butyl-2-(2-boronophenyl)benzimidazoles are accessed from the corresponding mono--alkyl--phenylenediamines, either using a polyphosphoric acid-mediated cyclisation with -bromobenzoic acid, or preferably using an Oxone™-mediated cyclisati... Read More about Synthesis and structure of bifunctional N-alkylbenzimidazole phenylboronate derivatives.