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Dr Tim Davies' Outputs (16)

Germ fate determinants protect germ precursor cell division by reducing septin and anillin levels at the cell division plane. (2024)
Journal Article
Connors, C. Q., Mauro, M. S., Wiles, J. T., Countryman, A. D., Martin, S. L., Lacroix, B., Shirasu-Hiza, M., Dumont, J., Kasza, K. E., Davies, T. R., & Canman, J. C. (2024). Germ fate determinants protect germ precursor cell division by reducing septin and anillin levels at the cell division plane. Molecular Biology of the Cell, 35(7), Article mbcE24020096T. https://doi.org/10.1091/mbc.E24-02-0096-T

Animal cell cytokinesis, or the physical division of one cell into two, is thought to be driven by constriction of an actomyosin contractile ring at the division plane. The mechanisms underlying cell type-specific differences in cytokinesis remain un... Read More about Germ fate determinants protect germ precursor cell division by reducing septin and anillin levels at the cell division plane..

Oligodendroglial macroautophagy is essential for myelin sheath turnover to prevent neurodegeneration and death (2022)
Journal Article
Aber, E. R., Griffey, C. J., Davies, T., Li, A. M., Yang, Y. J., Croce, K. R., Goldman, J. E., Grutzendler, J., Canman, J. C., & Yamamoto, A. (2022). Oligodendroglial macroautophagy is essential for myelin sheath turnover to prevent neurodegeneration and death. Cell Reports, 41(3), Article 111480. https://doi.org/10.1016/j.celrep.2022.111480

Although macroautophagy deficits are implicated across adult-onset neurodegenerative diseases, we understand little about how the discrete, highly evolved cell types of the central nervous system use macroautophagy to maintain homeostasis. One such c... Read More about Oligodendroglial macroautophagy is essential for myelin sheath turnover to prevent neurodegeneration and death.

CYK4 relaxes the bias in the off-axis motion by MKLP1 kinesin-6 (2021)
Journal Article
Maruyama, Y., Sugawa, M., Yamaguchi, S., Davies, T., Osaki, T., Kobayashi, T., Yamagishi, M., Takeuchi, S., Mishima, M., & Yajima, J. (2021). CYK4 relaxes the bias in the off-axis motion by MKLP1 kinesin-6. Communications Biology, 4, Article 180. https://doi.org/10.1038/s42003-021-01704-2

Centralspindlin, a complex of the MKLP1 kinesin-6 and CYK4 GAP subunits, plays key roles in metazoan cytokinesis. CYK4-binding to the long neck region of MKLP1 restricts the configuration of the two MKLP1 motor domains in the centralspindlin. However... Read More about CYK4 relaxes the bias in the off-axis motion by MKLP1 kinesin-6.

FHOD‐1 is the only formin in Caenorhabditis elegans that promotes striated muscle growth and Z‐line organization in a cell autonomous manner (2020)
Journal Article
Sundaramurthy, S., Votra, S., Laszlo, A., Davies, T., & Pruyne, D. (2020). FHOD‐1 is the only formin in Caenorhabditis elegans that promotes striated muscle growth and Z‐line organization in a cell autonomous manner. Cytoskeleton, 77(10), 422-441. https://doi.org/10.1002/cm.21639

The striated body wall muscles of Caenorhabditis elegans are a simple model for sarcomere assembly. Previously, we observed deletion mutants for two formin genes, fhod‐1 and cyk‐1, develop thin muscles with abnormal dense bodies (the sarcomere Z‐line... Read More about FHOD‐1 is the only formin in Caenorhabditis elegans that promotes striated muscle growth and Z‐line organization in a cell autonomous manner.

Cell-intrinsic and -extrinsic mechanisms promote cell-type-specific cytokinetic diversity (2018)
Journal Article
Davies, T., Kim, H. X., Romano Spica, N., Lesea-Pringle, B. J., Dumont, J., Shirasu-Hiza, M., & Canman, J. C. (2018). Cell-intrinsic and -extrinsic mechanisms promote cell-type-specific cytokinetic diversity. eLife, 7, Article e36204. https://doi.org/10.7554/elife.36204

Cytokinesis, the physical division of one cell into two, is powered by constriction of an actomyosin contractile ring. It has long been assumed that all animal cells divide by a similar molecular mechanism, but growing evidence suggests that cytokine... Read More about Cell-intrinsic and -extrinsic mechanisms promote cell-type-specific cytokinetic diversity.

Low Efficiency Upconversion Nanoparticles for High-Resolution Coalignment of Near-Infrared and Visible Light Paths on a Light Microscope (2017)
Journal Article
Sundaramoorthy, S., Garcia Badaracco, A., Hirsch, S. M., Park, J. H., Davies, T., Dumont, J., Shirasu-Hiza, M., Kummel, A. C., & Canman, J. C. (2017). Low Efficiency Upconversion Nanoparticles for High-Resolution Coalignment of Near-Infrared and Visible Light Paths on a Light Microscope. ACS Applied Materials and Interfaces, 9(9), 7929-7940. https://doi.org/10.1021/acsami.6b15322

Cortical PAR polarity proteins promote robust cytokinesis during asymmetric cell division (2016)
Journal Article
Jordan, S. N., Davies, T., Zhuravlev, Y., Dumont, J., Shirasu-Hiza, M., & Canman, J. C. (2016). Cortical PAR polarity proteins promote robust cytokinesis during asymmetric cell division. Journal of Cell Biology, 212(1), 39-49. https://doi.org/10.1083/jcb.201510063

Cytokinesis, the physical division of one cell into two, is thought to be fundamentally similar in most animal cell divisions and driven by the constriction of a contractile ring positioned and controlled solely by the mitotic spindle. During asymmet... Read More about Cortical PAR polarity proteins promote robust cytokinesis during asymmetric cell division.

CYK4 Promotes Antiparallel Microtubule Bundling by Optimizing MKLP1 Neck Conformation (2015)
Journal Article
Davies, T., Kodera, N., Kaminski Schierle, G. S., Rees, E., Erdelyi, M., Kaminski, C. F., Ando, T., & Mishima, M. (2015). CYK4 Promotes Antiparallel Microtubule Bundling by Optimizing MKLP1 Neck Conformation. PLoS Biology, 13(4), Article e1002121. https://doi.org/10.1371/journal.pbio.1002121

Centralspindlin, a constitutive 2:2 heterotetramer of MKLP1 (a kinesin-6) and the non-motor subunit CYK4, plays important roles in cytokinesis. It is crucial for the formation of central spindle microtubule bundle structure. Its accumulation at the c... Read More about CYK4 Promotes Antiparallel Microtubule Bundling by Optimizing MKLP1 Neck Conformation.