Professor David Sanderson's Outputs (5)

Dissecting spatial knowledge from spatial choice by hippocampal NMDA receptor deletion (2012)
Journal Article
Bannerman, D. M., Bus, T., Taylor, A., Sanderson, D. J., Schwarz, I., Jenson, V., …Sprengel, R. (2012). Dissecting spatial knowledge from spatial choice by hippocampal NMDA receptor deletion. Nature Neuroscience, 15(8), 1153-1159. https://doi.org/10.1038/nn.3166

Hippocampal NMDA receptors (NMDARs) and NMDAR-dependent synaptic plasticity are widely considered crucial substrates of long-term spatial memory, although their precise role remains uncertain. Here we show that Grin1ΔDGCA1 mice, lacking GluN1 and hen... Read More about Dissecting spatial knowledge from spatial choice by hippocampal NMDA receptor deletion.

Hippocampal lesions can enhance discrimination learning despite normal sensitivity to incidental information (2012)
Journal Article
Sanderson, D. J., Rawlins, J. N. P., Deacon, R. M. J., Cunningham, C., Barkus, C., & Bannerman, D. M. (2012). Hippocampal lesions can enhance discrimination learning despite normal sensitivity to incidental information. Hippocampus, 22(7), 1553-1566. https://doi.org/10.1002/hipo.20995

Spatial properties of stimuli are sometimes encoded even when incidental to the demands of a particular learning task. Incidental encoding of spatial information may interfere with learning by (i) causing a failure to generalize learning between tria... Read More about Hippocampal lesions can enhance discrimination learning despite normal sensitivity to incidental information.

Systemic inflammation induces acute working memory deficits in the primed brain: relevance for delirium (2012)
Journal Article
Murray, C., Sanderson, D. J., Barkus, C., Deacon, R. M. J., Rawlins, J. N. P., Bannerman, D. M., & Cunningham, C. (2012). Systemic inflammation induces acute working memory deficits in the primed brain: relevance for delirium. Neurobiology of Aging, 33(3), 603-616. https://doi.org/10.1016/j.neurobiolaging.2010.04.002

Delirium is an acute, severe neuropsychiatric syndrome, characterized by cognitive deficits, that is highly prevalent in aging and dementia and is frequently precipitated by peripheral infections. Delirium is poorly understood and the lack of biologi... Read More about Systemic inflammation induces acute working memory deficits in the primed brain: relevance for delirium.

Do GluA1 knockout mice exhibit behavioral abnormalities relevant to the negative or cognitive symptoms of schizophrenia and schizoaffective disorder (2012)
Journal Article
Barkus, C., Feyder, M., Graybeal, C., Wright, T., Wiedholz, L., Izquierdo, A., …Holmes, A. (2012). Do GluA1 knockout mice exhibit behavioral abnormalities relevant to the negative or cognitive symptoms of schizophrenia and schizoaffective disorder. Neuropharmacology, 62(3), 1263-1272. https://doi.org/10.1016/j.neuropharm.2011.06.005

The role of habituation in hippocampus-dependent spatial working memory: evidence from GluA1 AMPA receptor subunit knockout mice (2012)
Journal Article
Sanderson, D. J., & Bannerman, D. M. (2012). The role of habituation in hippocampus-dependent spatial working memory: evidence from GluA1 AMPA receptor subunit knockout mice. Hippocampus, 22(5), 981-994. https://doi.org/10.1002/hipo.20896

Spatial alternation, win-shift behavior has been claimed to be a test of working memory in rodents that requires active maintenance of relevant, trial-specific information. In this review, we describe work with GluA1 AMPA receptor subunit knockout mi... Read More about The role of habituation in hippocampus-dependent spatial working memory: evidence from GluA1 AMPA receptor subunit knockout mice.