Dr James Walton's Outputs (3)

C–H Activation of π-Arene Ruthenium Complexes (2017)
Journal Article
Wilkinson, L. A., Pike, J. A., & Walton, J. W. (2017). C–H Activation of π-Arene Ruthenium Complexes. Organometallics, 36(22), 4376-4381. https://doi.org/10.1021/acs.organomet.7b00563

We present a C–H activation protocol for aromatic compounds that overcomes the current limitations of the need for a directing group or covalently bound activating groups, by exploiting the increase in C–H acidity of aromatic compounds on π-coordinat... Read More about C–H Activation of π-Arene Ruthenium Complexes.

Perfluorinated HDAC inhibitors as Selective Anticancer Agents (2017)
Journal Article
Walton, J. W., Cross, J. M., Riedel, T., & Dyson, P. (2017). Perfluorinated HDAC inhibitors as Selective Anticancer Agents. Organic and Biomolecular Chemistry, 15(43), 9186-9190. https://doi.org/10.1039/c7ob02339a

A series of potent histone deacetylase inhibitors is presented that incorporate alkyl or perfluorinated alkyl chains. Several new compounds show greater in vitro antiproliferate activity than the clinically approved inhibitor, SAHA. Furthermore, the... Read More about Perfluorinated HDAC inhibitors as Selective Anticancer Agents.

Nucleophilic Trifluoromethylation of Electron-Deficient Arenes (2017)
Journal Article
Pike, J. A., & Walton, J. W. (2017). Nucleophilic Trifluoromethylation of Electron-Deficient Arenes. Chemical Communications, 53(71), https://doi.org/10.1039/c7cc05415g

A novel trifluoromethylation of arenes is presented, which proceeds under mild reaction conditions and has the potential for late-stage functionalisation of pharmaceuticals and agrochemicals. The new reaction allows for the regioselective conversion... Read More about Nucleophilic Trifluoromethylation of Electron-Deficient Arenes.