Professor Ian Baxendale's Outputs (7)

Copper-Mediated Nitrosation: 2-Nitrosophenolato Complexes and Their Use in the Synthesis of Heterocycles (2019)
Journal Article
Nicholls, A., Batsanov, A., & Baxendale, I. (2019). Copper-Mediated Nitrosation: 2-Nitrosophenolato Complexes and Their Use in the Synthesis of Heterocycles. Molecules, 24(22), Article 4154. https://doi.org/10.3390/molecules24224154

A simple protocol yielding ortho-substituted nitrosophenols from phenols is demonstrated, in the form of copper(II) bis(nitrosophenolato) complexes. The developed methodology was applied to a range of substrates, confirming the role of the copper in... Read More about Copper-Mediated Nitrosation: 2-Nitrosophenolato Complexes and Their Use in the Synthesis of Heterocycles.

The Synthesis and Utility of Metal-Nitrosophenolato Compounds—Highlighting the Baudisch Reaction (2019)
Journal Article
Nicholls, A., Barber, T., & Baxendale, I. (2019). The Synthesis and Utility of Metal-Nitrosophenolato Compounds—Highlighting the Baudisch Reaction. Molecules, 24(22), https://doi.org/10.3390/molecules24224018

The syntheses of the title compounds demonstrate a privileged introduction of a nitroso (and a hydroxyl via the Baudisch reaction) group to an aromatic ring. These complexes first appeared in the literature as early as 1939, and a range of applicatio... Read More about The Synthesis and Utility of Metal-Nitrosophenolato Compounds—Highlighting the Baudisch Reaction.

A simple and efficient flow preparation of pyocyanin a virulence factor of Pseudomonas aeruginosa (2019)
Journal Article
Mortzfeld, F., Pietruszka, J., & Baxendale, I. (2019). A simple and efficient flow preparation of pyocyanin a virulence factor of Pseudomonas aeruginosa. European Journal of Organic Chemistry, 2019(31-32), 5424-5433. https://doi.org/10.1002/ejoc.201900526

The synthesis of the naturally occurring toxin pyocyanin has been realized in a short 4 step sequence. The key photochemical reaction and isolation of the final product has been facilitated by the use of flow chemistry techniques and immobilised reag... Read More about A simple and efficient flow preparation of pyocyanin a virulence factor of Pseudomonas aeruginosa.

Photochemical flow synthesis of 3‐hydroxyazetidines (2019)
Journal Article
Ruggeri, M., Dombrowski, A. W., Djuric, S. W., & Baxendale, I. R. (in press). Photochemical flow synthesis of 3‐hydroxyazetidines. ChemPhotoChem, https://doi.org/10.1002/cptc.201900188

A photo‐flow Norrish‐Yang cyclisation has been devised that delivers 3‐hydroxyazetidines in good yields. The high reproducibility and short residence times of the flow process enables easy scaling of the transformation allowing access to these valuab... Read More about Photochemical flow synthesis of 3‐hydroxyazetidines.

Flow Hydrodediazoniation of Aromatic Heterocycles (2019)
Journal Article
Röder, L., Nicholls, A. J., & Baxendale, I. R. (2019). Flow Hydrodediazoniation of Aromatic Heterocycles. Molecules, 24(10), Article 1996. https://doi.org/10.3390/molecules24101996

Continuous flow processing was applied for the rapid replacement of an aromatic amino group with a hydride. The approach was applied to a range of aromatic heterocycles, confirming the wide scope and substituent-tolerance of the processes. Flow equip... Read More about Flow Hydrodediazoniation of Aromatic Heterocycles.

A solid-supported arylboronic acid catalyst for direct amidation (2019)
Journal Article
Du, Y., Barber, T., Lim, S. E., Rzepa, H. S., Baxendale, I. R., & Whiting, A. (2019). A solid-supported arylboronic acid catalyst for direct amidation. Chemical Communications, 55(20), 2916-2919. https://doi.org/10.1039/c8cc09913h

An efficient heterogeneous amidation catalyst has been prepared by co-polymerisation of styrene, DVB with 4-styreneboronic acid, which shows wide substrate applicability and higher reactivity than the equivalent homogeneous phenylboronic acid, sugges... Read More about A solid-supported arylboronic acid catalyst for direct amidation.

Synthesis of new derivatives of boehmeriasin A and their biological evaluation in liver cancer (2019)
Journal Article
Güzelcan, E. A., Baxendale, I. R., Cetin-Atalay, R., & Baumann, M. (2019). Synthesis of new derivatives of boehmeriasin A and their biological evaluation in liver cancer. European Journal of Medicinal Chemistry, 166, 243-255. https://doi.org/10.1016/j.ejmech.2019.01.056

Two series of boehmeriasin A analogs have been synthesized in short and high yielding processes providing derivatives differing either in the alkaloid's pentacyclic scaffold or its peripheral substitution pattern. These series have enabled, for the f... Read More about Synthesis of new derivatives of boehmeriasin A and their biological evaluation in liver cancer.