A simple and efficient flow preparation of pyocyanin a virulence factor of Pseudomonas aeruginosa

Mortzfeld, F.; Pietruszka, J.; Baxendale, I.R.

Abstract

The synthesis of the naturally occurring toxin pyocyanin has been realized in a short 4 step sequence. The key photochemical reaction and isolation of the final product has been facilitated by the use of flow chemistry techniques and immobilised reagents. Using these procedures gram quantities of pyocyanin were easily prepared in high yield and purity.

Citation

Mortzfeld, F., Pietruszka, J., & Baxendale, I. (2019). A simple and efficient flow preparation of pyocyanin a virulence factor of Pseudomonas aeruginosa. European Journal of Organic Chemistry, 2019(31-32), 5424-5433. https://doi.org/10.1002/ejoc.201900526

• Journal Article Type: Article
• Acceptance Date: May 6, 2019
• Publication Date: Sep 1, 2019
• Deposit Date: May 7, 2019
• Journal: European Journal of Organic Chemistry
• Print ISSN: 1434-193X
• Electronic ISSN: 1099-0690
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 2019
• Issue: 31-32
• Pages: 5424-5433
• DOI: https://doi.org/10.1002/ejoc.201900526.
• Public URL: https://durham-repository.worktribe.com/output/1302579