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Dr Karrera Djoko's Outputs (3)

Copper(II)-Bis(Thiosemicarbazonato) Complexes as Antibacterial Agents: Insights into Their Mode of Action and Potential as Therapeutics (2015)
Journal Article
Djoko, K. Y., Goytia, M. M., Donnelly, P. S., Schembri, M. A., Shafer, W. M., & McEwan, A. G. (2015). Copper(II)-Bis(Thiosemicarbazonato) Complexes as Antibacterial Agents: Insights into Their Mode of Action and Potential as Therapeutics. Antimicrobial Agents and Chemotherapy, 59(10), 6444-6453. https://doi.org/10.1128/aac.01289-15

There is increasing interest in the use of lipophilic copper (Cu)-containing complexes to combat bacterial infections. In this work, we showed that Cu complexes with bis(thiosemicarbazone) ligands [Cu(btsc)] exert antibacterial activity against a ran... Read More about Copper(II)-Bis(Thiosemicarbazonato) Complexes as Antibacterial Agents: Insights into Their Mode of Action and Potential as Therapeutics.

The Role of Copper and Zinc Toxicity in Innate Immune Defense against Bacterial Pathogens (2015)
Journal Article
Djoko, K. Y., Ong, C. Y., Walker, M. J., & McEwan, A. G. (2015). The Role of Copper and Zinc Toxicity in Innate Immune Defense against Bacterial Pathogens. Journal of Biological Chemistry, 290(31), 18954-18961. https://doi.org/10.1074/jbc.r115.647099

Zinc (Zn) and copper (Cu) are essential for optimal innate immune function, and nutritional deficiency in either metal leads to increased susceptibility to bacterial infection. Recently, the decreased survival of bacterial pathogens with impaired Cu... Read More about The Role of Copper and Zinc Toxicity in Innate Immune Defense against Bacterial Pathogens.

A genetic screen reveals a periplasmic copper chaperone required for nitrite reductase activity in pathogenic Neisseria (2015)
Journal Article
Jen, F. C., Djoko, K., Bent, S., Day, C., McEwan, A., & Jennings, M. (2015). A genetic screen reveals a periplasmic copper chaperone required for nitrite reductase activity in pathogenic Neisseria. FASEB Journal, 29(9), 3828-3838. https://doi.org/10.1096/fj.15-270751

Under conditions of low oxygen availability, Neisseria meningitidis and Neisseria gonorrhoeae are able to respire via a partial denitrification pathway in which nitrite is converted to nitrous oxide. In this process, nitrite reductase (AniA), a coppe... Read More about A genetic screen reveals a periplasmic copper chaperone required for nitrite reductase activity in pathogenic Neisseria.