The Role of Copper and Zinc Toxicity in Innate Immune Defense against Bacterial Pathogens

Djoko, Karrera Y.; Ong, Cheryl-lynn Y.; Walker, Mark J.; McEwan, Alastair G.

Abstract

Zinc (Zn) and copper (Cu) are essential for optimal innate immune function, and nutritional deficiency in either metal leads to increased susceptibility to bacterial infection. Recently, the decreased survival of bacterial pathogens with impaired Cu and/or Zn detoxification systems in phagocytes and animal models of infection has been reported. Consequently, a model has emerged in which the host utilizes Cu and/or Zn intoxication to reduce the intracellular survival of pathogens. This review describes and assesses the potential role for Cu and Zn intoxication in innate immune function and their direct bactericidal function.

Citation

Djoko, K. Y., Ong, C. Y., Walker, M. J., & McEwan, A. G. (2015). The Role of Copper and Zinc Toxicity in Innate Immune Defense against Bacterial Pathogens. Journal of Biological Chemistry, 290(31), 18954-18961. https://doi.org/10.1074/jbc.r115.647099

• Journal Article Type: Article
• Online Publication Date: Jun 8, 2015
• Publication Date: Jun 30, 2015
• Deposit Date: Sep 6, 2017
• Publicly Available Date: Oct 17, 2017
• Journal: Journal of Biological Chemistry
• Print ISSN: 0021-9258
• Electronic ISSN: 1083-351X
• Publisher: American Society for Biochemistry and Molecular Biology
• Peer Reviewed: Peer Reviewed
• Volume: 290
• Issue: 31
• Pages: 18954-18961
• DOI: https://doi.org/10.1074/jbc.r115.647099
• Public URL: https://durham-repository.worktribe.com/output/1377204