Dr Christopher Ottley's Outputs (79)

Therapy-induced carboplatin-DNA adduct levels in human ovarian tumours in relation to assessment of adduct measurement in mouse tissues (2011)
Journal Article
Jarvis, I., Meczes, E., Thomas, H., Edmondson, R., Veal, G., Boddy, A., …Tilby, M. (2012). Therapy-induced carboplatin-DNA adduct levels in human ovarian tumours in relation to assessment of adduct measurement in mouse tissues. Biochemical Pharmacology, 83(1), 69-77. https://doi.org/10.1016/j.bcp.2011.10.005

Despite an increasing understanding of the molecular mechanisms by which platinum drug DNA adducts interact with cellular processes, the relationship between adduct formation in tumours and clinical response remains unclear. We have determined carbop... Read More about Therapy-induced carboplatin-DNA adduct levels in human ovarian tumours in relation to assessment of adduct measurement in mouse tissues.

A Phase I clinical study of cisplatin-incorporated polymeric micelles (NC-6004) in patients with solid tumours (2011)
Journal Article
Plummer, R., Wilson, R., Calvert, H., Boddy, A., Griffin, M., Sludden, J., …Nishiya, T. (2011). A Phase I clinical study of cisplatin-incorporated polymeric micelles (NC-6004) in patients with solid tumours. British Journal of Cancer, 104(4), 593-598. https://doi.org/10.1038/bjc.2011.6

Background: On the basis of preclinical studies of NC-6004, a cisplatin-incorporated micellar formulation, we hypothesised that NC-6004 could show lower toxicity than cisplatin and show greater anti-tumour activity in phase I study. Methods: A total... Read More about A Phase I clinical study of cisplatin-incorporated polymeric micelles (NC-6004) in patients with solid tumours.

Mixed fluid sources involved in diamond growth constrained by Sr-Nd-Pb-C-N isotopes and trace elements (2010)
Journal Article
Klein-BenDavid, O., Pearson, D., Nowell, G., Ottley, C., McNeill, J., & Cartigny, P. (2010). Mixed fluid sources involved in diamond growth constrained by Sr-Nd-Pb-C-N isotopes and trace elements. Earth and Planetary Science Letters, 289(1-2), 123-133. https://doi.org/10.1016/j.epsl.2009.10.035

From source to crust: Tracing magmatic evolution in a kimberlite and a melilitite using microsample geochemistry. (2010)
Journal Article
Malarkey, J., Pearson, D., Kjarsgaard, B., Davidson, J., Nowell, G., Ottley, C., & Stammer, J. (2010). From source to crust: Tracing magmatic evolution in a kimberlite and a melilitite using microsample geochemistry. Earth and Planetary Science Letters, 299(1-2), 80-90. https://doi.org/10.1016/j.epsl.2010.08.020

We present an integrated microsampling trace element and isotopic study of primary minerals within the Jos kimberlite, Canada, in order to observe how different phases record progressive crustal interaction in the evolving kimberlite. Identification... Read More about From source to crust: Tracing magmatic evolution in a kimberlite and a melilitite using microsample geochemistry..

Formation of the North Atlantic Craton: Timing and mechanisms constrained from Re-Os isotope and PGE data of peridotite xenoliths from SW Greenland (2010)
Journal Article
Wittig, N., Webb, M., Pearson, D., Dale, C., Ottley, C., Hutchison, M., …Luguet, A. (2010). Formation of the North Atlantic Craton: Timing and mechanisms constrained from Re-Os isotope and PGE data of peridotite xenoliths from SW Greenland. Chemical Geology, 276(3-4), 166-187. https://doi.org/10.1016/j.chemgeo.2010.06.002

Podiform chromitites and mantle peridotites of the Antalya ophiolite, Isparta Angle (SW Turkey): Implications for partial melting and melt-rock interaction in oceanic and subduction-related settings. (2010)
Journal Article
Caran, S., Coban, H., Flower, M. F., Ottley, C., & Yilmaz, K. (2010). Podiform chromitites and mantle peridotites of the Antalya ophiolite, Isparta Angle (SW Turkey): Implications for partial melting and melt-rock interaction in oceanic and subduction-related settings. Lithos, 114(3-4), 307-326. https://doi.org/10.1016/j.lithos.2009.09.006

Quantitative analysis of trace element concentrations in some gem-quality diamonds (2009)
Journal Article
McNeill, J., Pearson, D., Klein-BenDavid, O., Nowell, G., Ottley, C., & Chinn, I. (2009). Quantitative analysis of trace element concentrations in some gem-quality diamonds. Journal of Physics: Condensed Matter, 21(36), https://doi.org/10.1088/0953-8984/21/36/364207

The kinase inhibitor O(6)-cyclohexylmethylguanine (NU2058) potentiates the cytotoxicity of cisplatin by mechanisms that are independent of its effect upon CDK2. (2009)
Journal Article
Harrison, L. R., Ottley, C. J., Pearson, D. G., Roche, C., Wedge, S. R., Dolan, M. E., …Tilby, M. J. (2009). The kinase inhibitor O(6)-cyclohexylmethylguanine (NU2058) potentiates the cytotoxicity of cisplatin by mechanisms that are independent of its effect upon CDK2. Biochemical Pharmacology, 77, 1586-1592. https://doi.org/10.1016/j.bcp.2009.02.018

Combined Sr isotope and trace element analysis of melt inclusions at sub-ng levels using micro-milling, TIMS and ICPMS (2009)
Journal Article
Harlou, R., Pearson, D., Nowell, G., Ottley, C., & Davidson, J. (2009). Combined Sr isotope and trace element analysis of melt inclusions at sub-ng levels using micro-milling, TIMS and ICPMS. Chemical Geology, 260(3-4), 254-268. https://doi.org/10.1016/j.chemgeo.2008.12.020

Cellular and molecular mechanisms for the synergistic cytotoxicity elicited by oxaliplatin and pemetrexed in colon cancer cell lines (2009)
Journal Article
Nannizzi, S., Veal, G. J., Giovannetti, E., Mey, V., Ricciardi, S., Ottley, C. J., Del Tacca, M., & Danesi, R. (2010). Cellular and molecular mechanisms for the synergistic cytotoxicity elicited by oxaliplatin and pemetrexed in colon cancer cell lines. Cancer Chemotherapy and Pharmacology, 66(3), 547-558. https://doi.org/10.1007/s00280-009-1195-2

Purpose
Oxaliplatin effect in the treatment of colorectal cancer is improved upon combination with thymidylate synthase (TS) inhibitors. Pemetrexed is polyglutamated by the folylpolyglutamate synthase (FPGS) and blocks folate metabolism and DNA synt... Read More about Cellular and molecular mechanisms for the synergistic cytotoxicity elicited by oxaliplatin and pemetrexed in colon cancer cell lines.

Contribution of HIF-1 and drug penetrance to oxaliplatin resistance in hypoxic colorectal cancer cells (2009)
Journal Article
Roberts, D., Williams, K., Cowen, R., Barathova, M., Eustace, A., Brittain-Dissont, S., …Dive, C. (2009). Contribution of HIF-1 and drug penetrance to oxaliplatin resistance in hypoxic colorectal cancer cells. British Journal of Cancer, 101(8), 1290-1297. https://doi.org/10.1038/sj.bjc.6605311

Background: Hypoxia is as an indicator of poor treatment outcome. Consistently, hypoxic HCT116 colorectal cancer cells are resistant to oxaliplatin, although the mechanistic basis is unclear. This study sought to investigate the relative contribution... Read More about Contribution of HIF-1 and drug penetrance to oxaliplatin resistance in hypoxic colorectal cancer cells.

Bozkurt Erdin; Winchester John A.; Yigitbas Erdinc and Ottley Christopher J.. Proterozoic ophiolites and mafic-ultramafic complexes marginal to the Istanbul Block: An exotic terrane of Avalonian affinity in NW Turkey. (2008)
Journal Article
Bozkurt, E., Winchester, J. A., Yigitbas, E., & Ottley, C. J. (2008). Bozkurt Erdin; Winchester John A.; Yigitbas Erdinc and Ottley Christopher J.. Proterozoic ophiolites and mafic-ultramafic complexes marginal to the Istanbul Block: An exotic terrane of Avalonian affinity in NW Turkey. Tectonophysics, 461, 240-251

Origin of cratonic lithospheric mantle roots: A geochemical study of peridotites from the North Atlantic Craton, West Greenland (2008)
Journal Article
Wittig, N., Pearson, D., Webb, M., Ottley, C., Irvine, G., Kopylova, M., …Nowell, G. (2008). Origin of cratonic lithospheric mantle roots: A geochemical study of peridotites from the North Atlantic Craton, West Greenland. Earth and Planetary Science Letters, 274(1-2), 24-33. https://doi.org/10.1016/j.epsl.2008.06.034

Substituted beta-cyclodextrin and calix[4]arene as encapsulatory vehicles for platinum(II)-based DNA intercalators (2008)
Journal Article
Krause-Heuer, A. M., Wheate, N. J., Tilby, M. J., Pearson, G. D., Ottley, C. J., & Aldrich-Wright, J. R. (2008). Substituted beta-cyclodextrin and calix[4]arene as encapsulatory vehicles for platinum(II)-based DNA intercalators. Inorganic Chemistry, 47, 6880-6888

Yigitbas Erdinc; Winchester John A.; Ottley Christopher J. (2008). The geochemistry and setting of the Demirci paragneisses of the Sunnice Massif, NW Turkey. (2008)
Journal Article
Yigitbas, E., Winchester, J. A., & Ottley, C. J. (2008). Yigitbas Erdinc; Winchester John A.; Ottley Christopher J. (2008). The geochemistry and setting of the Demirci paragneisses of the Sunnice Massif, NW Turkey. Turkish journal of earth sciences, 17, 421-431

Sr and Pb isotope micro-analysis in plagioclase crystals from Skye lavas: An insight into open-system processes in a flood basalt province (2008)
Journal Article
Font, L., Davidson, J., Pearson, D., Nowell, G., Jerram, D., & Ottley, C. (2008). Sr and Pb isotope micro-analysis in plagioclase crystals from Skye lavas: An insight into open-system processes in a flood basalt province. Journal of Petrology, 49(8), 1449-1471. https://doi.org/10.1093/petrology/egn032

Crystals in many magmatic rocks are heterogeneous in terms of their isotope composition. Detailed crystal-isotope stratigraphy (CIS) studies have shown that crystals act as reliable recorders of their magma source composition and of the pathways of m... Read More about Sr and Pb isotope micro-analysis in plagioclase crystals from Skye lavas: An insight into open-system processes in a flood basalt province.

Sr istope analysis of bird feathers by TIMS: a tool to trace bird migration paths and breeding sites (2007)
Journal Article
Font, L., Nowell, G., Pearson, D., Ottley, C., & Willis, S. (2007). Sr istope analysis of bird feathers by TIMS: a tool to trace bird migration paths and breeding sites. Journal of Analytical Atomic Spectrometry, 22, 513-522

LAPITA MIGRANTS IN THE PACIFIC’S OLDEST CEMETERY:ISOTOPIC ANALYSIS AT TEOUMA, VANUATU (2007)
Journal Article
Alexander Bentley, R., Buckley, H. R., Spriggs, M., Bedford, S., Ottley, C. J., Nowell, G. M., …Graham Pearson, D. (2007). LAPITA MIGRANTS IN THE PACIFIC’S OLDEST CEMETERY:ISOTOPIC ANALYSIS AT TEOUMA, VANUATU. American Antiquity, 72, 645-656

Teouma, an archaeological site on Efate Island, Vanuatu, features the earliest cemetery yet discovered of the colonizers of Remote Oceania, from the late second millennium B.C. In order to investigate potential migration of seventeen human individual... Read More about LAPITA MIGRANTS IN THE PACIFIC’S OLDEST CEMETERY:ISOTOPIC ANALYSIS AT TEOUMA, VANUATU.

Platinum-group elements (Ir, Pd, Pt and Rh) in road deposited sediments in two urban watersheds, Hawaii (2007)
Journal Article
Sutherland, R., Pearson, D., & Ottley, C. (2007). Platinum-group elements (Ir, Pd, Pt and Rh) in road deposited sediments in two urban watersheds, Hawaii. Applied Geochemistry, 22(7), 1485-1501. https://doi.org/10.1016/j.apgeochem.2007.04.008

This study represents the first detailed investigation of platinum-group elements (PGEs) in road-deposited sediment (RDS) in Hawaii, USA. Thirty-three sample locations, in two urban watersheds in Honolulu, Oahu, Hawaii were sampled. The <63 μm fracti... Read More about Platinum-group elements (Ir, Pd, Pt and Rh) in road deposited sediments in two urban watersheds, Hawaii.

Origin of CFB magmatism: Multi-tiered intracrustal picrite-rhyolite magmatic plumbing at Spitzkoppe, western Namibia, during early-Cretaceous Etendeka magmatism (2007)
Journal Article
Thompson, R., Riches, A., Antoshechkina, P., Pearson, D., Nowell, G., Ottley, C., …Niku-Paavola, V. (2007). Origin of CFB magmatism: Multi-tiered intracrustal picrite-rhyolite magmatic plumbing at Spitzkoppe, western Namibia, during early-Cretaceous Etendeka magmatism. Journal of Petrology, 48(6), 1119-1154. https://doi.org/10.1093/petrology/egm012

Early Cretaceous tholeiitic picrite-to-rhyolite dykes around Spitzkoppe, western Namibia, are part of the extensive Henties Bay–Outjo swarm, penecontemporaneous with 132 Ma Etendeka lavas 100 km to the NW. Although only intermediate to rhyolitic dyke... Read More about Origin of CFB magmatism: Multi-tiered intracrustal picrite-rhyolite magmatic plumbing at Spitzkoppe, western Namibia, during early-Cretaceous Etendeka magmatism.