Professor Patrick Steel's Outputs (4)

Antileishmanial Chemotherapy through Clemastine Fumarate Mediated Inhibition of the Leishmania Inositol Phosphorylceramide Synthase (2020)
Journal Article
Mina, J. G., Charlton, R. L., Alpizar-Sosa, E., Escrivani, D. O., Brown, C., Alqaisi, A., Borsodi, M. P. G., Figueiredo, C. P., de Lima, E. V., Dickie, E. A., Wei, W., Coutinho-Silva, R., Merritt, A., Smith, T. K., Barrett, M. P., Rossi-Bergmann, B., Denny, P. W., & Steel, P. G. (2021). Antileishmanial Chemotherapy through Clemastine Fumarate Mediated Inhibition of the Leishmania Inositol Phosphorylceramide Synthase. ACS Infectious Diseases, 7(1), 47-63. https://doi.org/10.1021/acsinfecdis.0c00546

Current chemotherapeutics for leishmaniasis have multiple deficiencies, and there is a need for new safe, efficacious, and affordable medicines. This study describes a successful drug repurposing approach that identifies the over-the-counter antihist... Read More about Antileishmanial Chemotherapy through Clemastine Fumarate Mediated Inhibition of the Leishmania Inositol Phosphorylceramide Synthase.

Basal stomatal aperture is regulated by GA-DELLAs in Arabidopsis (2020)
Journal Article
Sukiran, N. A., Steel, P. G., & Knight, M. R. (2020). Basal stomatal aperture is regulated by GA-DELLAs in Arabidopsis. Journal of Plant Physiology, 250, Article 153182. https://doi.org/10.1016/j.jplph.2020.153182

Stomatal aperture is tightly regulated in order to achieve the best compromise between gas exchange and water conservation. Steady-state (basal) stomatal aperture is therefore understandably a key component in plant fitness. It has been shown previou... Read More about Basal stomatal aperture is regulated by GA-DELLAs in Arabidopsis.

Single-dose treatment for cutaneous leishmaniasis with an easily synthesized chalcone entrapped in polymeric microparticles (2020)
Journal Article
Sousa-Batista, A. J., Arruda-Costa, N., Escrivani, D. O., Reynaud, F., Steel, P. G., & Rossi-Bergmann, B. (2020). Single-dose treatment for cutaneous leishmaniasis with an easily synthesized chalcone entrapped in polymeric microparticles. Parasitology, 147(9), 1032-1037. https://doi.org/10.1017/s0031182020000712

Cutaneous leishmaniasis (CL) is a major health problem in many countries and its current treatment involves multiple parenteral injections with toxic drugs and requires intensive health services. Previously, the efficacy of a single subcutaneous inje... Read More about Single-dose treatment for cutaneous leishmaniasis with an easily synthesized chalcone entrapped in polymeric microparticles.

Iridium Catalysed C-H Borylation of Heteroarenes: Balancing steric and electronic regiocontrol (2020)
Journal Article
Wright, J. S., Scott, P. J., & Steel, P. G. (2021). Iridium Catalysed C-H Borylation of Heteroarenes: Balancing steric and electronic regiocontrol. Angewandte Chemie International Edition, 60(6), 2796-2821. https://doi.org/10.1002/anie.202001520

Over the past twenty years, the iridium catalysed borylation of aromatic C‐H bonds has become the method for the synthesis of aromatic organoboron compounds required for many purposes including applications in natural product synthesis, material scie... Read More about Iridium Catalysed C-H Borylation of Heteroarenes: Balancing steric and electronic regiocontrol.