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TREATMENT OF LEISHMANIASIS (2024)
Patent
Denny, P., Steel, P., & Lyne, V. (2024). TREATMENT OF LEISHMANIASIS. WO 2024/084186 A1

The invention relates to compounds of formula (I), which may be used in the treatment of microbial infections. In particular, compounds of formula (I) are effective at treating leishmaniasis. The invention extends to novel compositions, therapies and... Read More about TREATMENT OF LEISHMANIASIS.

Applications of Transition Metal-Catalyzed ortho-Fluorine-Directed C–H Functionalization of (Poly)fluoroarenes in Organic Synthesis (2024)
Journal Article
Budiman, Y. P., Perutz, R. N., Steel, P. G., Radius, U., & Marder, T. B. (2024). Applications of Transition Metal-Catalyzed ortho-Fluorine-Directed C–H Functionalization of (Poly)fluoroarenes in Organic Synthesis. Chemical Reviews, 124(8), 4822-4862. https://doi.org/10.1021/acs.chemrev.3c00793

The synthesis of organic compounds efficiently via fewer steps but in higher yields is desirable as this reduces energy and reagent use, waste production, and thus environmental impact as well as cost. The reactivity of C–H bonds ortho to fluorine su... Read More about Applications of Transition Metal-Catalyzed ortho-Fluorine-Directed C–H Functionalization of (Poly)fluoroarenes in Organic Synthesis.

Synthesis and vectorial functionalisation of pyrazolo[3,4- c ]pyridines (2023)
Journal Article
Bedwell, E. V., da Silva Emery, F., Clososki, G. C., & Steel, P. G. (2023). Synthesis and vectorial functionalisation of pyrazolo[3,4- c ]pyridines. RSC Advances, 13(49), 34391-34399. https://doi.org/10.1039/d3ra07458g

Heterocycles are a cornerstone of fragment-based drug discovery (FBDD) due to their prevalence in biologically active compounds. However, novel heterocyclic fragments are only valuable if they can be suitably elaborated to compliment a chosen target... Read More about Synthesis and vectorial functionalisation of pyrazolo[3,4- c ]pyridines.

Inhibition of HSP90 distinctively modulates the global phosphoproteome of Leishmania mexicana developmental stages (2023)
Journal Article
Porta, E. O., Gao, L., Denny, P. W., Steel, P. G., & Kalesh, K. (2023). Inhibition of HSP90 distinctively modulates the global phosphoproteome of Leishmania mexicana developmental stages. Microbiology Spectrum, https://doi.org/10.1128/spectrum.02960-23

Heat shock protein 90 (HSP90) is an evolutionarily conserved chaperone protein that plays a central role in the folding and maturation of a large array of client proteins. In the unicellular parasite Leishmania, the etiological agent of the neglected... Read More about Inhibition of HSP90 distinctively modulates the global phosphoproteome of Leishmania mexicana developmental stages.

Assessing Dose-Exposure-Response Relationships of Miltefosine in Adults and Children using Physiologically-Based Pharmacokinetic Modeling Approach. (2023)
Journal Article
Madu, S. J., Wang, K., Chirumamilla, S. K., Turner, D. B., Steel, P. G., & Li, M. (2023). Assessing Dose-Exposure-Response Relationships of Miltefosine in Adults and Children using Physiologically-Based Pharmacokinetic Modeling Approach. Pharmaceutical Research, 10.1007/s11095-023-03610-0. https://doi.org/10.1007/s11095-023-03610-0

Miltefosine is the first and only oral medication to be successfully utilized as an antileishmanial agent. However, the drug is associated with differences in exposure patterns and cure rates among different population groups e.g. ethnicity and age (... Read More about Assessing Dose-Exposure-Response Relationships of Miltefosine in Adults and Children using Physiologically-Based Pharmacokinetic Modeling Approach..

Disruption of the inositol phosphorylceramide synthase gene affects Trypanosoma cruzi differentiation and infection capacity (2023)
Journal Article
Dos Santos, N. S. A., Estevez-Castro, C. F., Macedo, J. P., Chame, D. F., Castro-Gomes, T., Santos-Cardoso, M., …Teixeira, S. M. R. (2023). Disruption of the inositol phosphorylceramide synthase gene affects Trypanosoma cruzi differentiation and infection capacity. PLoS Neglected Tropical Diseases, 17(9), Article e0011646. https://doi.org/10.1371/journal.pntd.0011646

Sphingolipids (SLs) are essential components of all eukaryotic cellular membranes. In fungi, plants and many protozoa, the primary SL is inositol-phosphorylceramide (IPC). Trypanosoma cruzi is a protozoan parasite that causes Chagas disease (CD), a c... Read More about Disruption of the inositol phosphorylceramide synthase gene affects Trypanosoma cruzi differentiation and infection capacity.

Navigating drug repurposing for Chagas disease: advances, challenges, and opportunities (2023)
Journal Article
Porta, E. O. J., Kalesh, K., & Steel, P. G. (2023). Navigating drug repurposing for Chagas disease: advances, challenges, and opportunities. Frontiers in Pharmacology, 14(2023), https://doi.org/10.3389/fphar.2023.1233253

Chagas disease is a vector-borne illness caused by the protozoan parasite Trypanosoma cruzi (T. cruzi). It poses a significant public health burden, particularly in the poorest regions of Latin America. Currently, there is no available vaccine, and c... Read More about Navigating drug repurposing for Chagas disease: advances, challenges, and opportunities.

Iridium‐Catalysed C−H Borylation of Fluoroarenes: Insights into the Balance between Steric and Electronic Control of Regioselectivity (2022)
Journal Article
Ding, M., Reuven, J. A., Hones, A. C., Fox, M. A., & Steel, P. G. (2022). Iridium‐Catalysed C−H Borylation of Fluoroarenes: Insights into the Balance between Steric and Electronic Control of Regioselectivity. European Journal of Organic Chemistry, 2022(47), https://doi.org/10.1002/ejoc.202201005

The iridium catalysed C−H borylation of polyfluorinated arenes and heteroarenes occurs rapidly and efficiently. As with other borylation reactions, whilst steric parameters dominate, an underlying electronic influence on reaction selectivity can be o... Read More about Iridium‐Catalysed C−H Borylation of Fluoroarenes: Insights into the Balance between Steric and Electronic Control of Regioselectivity.

Integral Role of Water in the Solid-State Behavior of the Antileishmanial Drug Miltefosine (2022)
Journal Article
Hall, A. V., Gostick, I. E., Yufit, D. S., Marchant, G. Y., Kirubakaran, P., Madu, S. J., …Steed, J. W. (2022). Integral Role of Water in the Solid-State Behavior of the Antileishmanial Drug Miltefosine. Crystal Growth and Design, 22(10), 6262-6266. https://doi.org/10.1021/acs.cgd.2c00843

Miltefosine is a repurposed anticancer drug and currently the only orally administered drug approved to treat the neglected tropical disease leishmaniasis. Miltefosine is hygroscopic and must be stored at subzero temperatures. In this work, we report... Read More about Integral Role of Water in the Solid-State Behavior of the Antileishmanial Drug Miltefosine.

Discovery of Leishmania Druggable Serine Proteases by Activity-Based Protein Profiling (2022)
Journal Article
Porta, E. O., Isern, J. A., Kalesh, K., & Steel, P. G. (2022). Discovery of Leishmania Druggable Serine Proteases by Activity-Based Protein Profiling. Frontiers in Pharmacology, 13, https://doi.org/10.3389/fphar.2022.929493

Leishmaniasis are a group of diseases caused by parasitic protozoa of the genus Leishmania. Current treatments are limited by difficult administration, high cost, poor efficacy, toxicity, and growing resistance. New agents, with new mechanisms of act... Read More about Discovery of Leishmania Druggable Serine Proteases by Activity-Based Protein Profiling.

Plant growth promotion by the interaction of a novel synthetic small molecule with GA‐DELLA function (2022)
Journal Article
Sukiran, N. A., Pollastri, S., Steel, P. G., & Knight, M. R. (2022). Plant growth promotion by the interaction of a novel synthetic small molecule with GA‐DELLA function. Plant Direct, 6(4), Article e398. https://doi.org/10.1002/pld3.398

Synthesized small molecules are useful as tools to investigate hormonal signaling involved in plant growth and development. They are also important as agrochemicals to promote beneficial properties of crops in the field. We describe here the synthesi... Read More about Plant growth promotion by the interaction of a novel synthetic small molecule with GA‐DELLA function.

Flavonoid-based inhibitors of the Phi-class glutathione transferase from black-grass to combat multiple herbicide resistance (2021)
Journal Article
Schwarz, M., Eno, R. F., Freitag-Pohl, S., Coxon, C. R., Straker, H. E., Wortley, D. J., …Steel, P. G. (2021). Flavonoid-based inhibitors of the Phi-class glutathione transferase from black-grass to combat multiple herbicide resistance. Organic and Biomolecular Chemistry, 19(42), 9211-9222. https://doi.org/10.1039/d1ob01802g

The evolution and growth of multiple-herbicide resistance (MHR) in grass weeds continues to threaten global cereal production. While various processes can contribute to resistance, earlier work has identified the phi class glutathione-S-transferase (... Read More about Flavonoid-based inhibitors of the Phi-class glutathione transferase from black-grass to combat multiple herbicide resistance.

Antileishmanial Chemotherapy through Clemastine Fumarate Mediated Inhibition of the Leishmania Inositol Phosphorylceramide Synthase (2020)
Journal Article
Mina, J. G., Charlton, R. L., Alpizar-Sosa, E., Escrivani, D. O., Brown, C., Alqaisi, A., …Steel, P. G. (2021). Antileishmanial Chemotherapy through Clemastine Fumarate Mediated Inhibition of the Leishmania Inositol Phosphorylceramide Synthase. ACS Infectious Diseases, 7(1), 47-63. https://doi.org/10.1021/acsinfecdis.0c00546

Current chemotherapeutics for leishmaniasis have multiple deficiencies, and there is a need for new safe, efficacious, and affordable medicines. This study describes a successful drug repurposing approach that identifies the over-the-counter antihist... Read More about Antileishmanial Chemotherapy through Clemastine Fumarate Mediated Inhibition of the Leishmania Inositol Phosphorylceramide Synthase.

Basal stomatal aperture is regulated by GA-DELLAs in Arabidopsis (2020)
Journal Article
Sukiran, N. A., Steel, P. G., & Knight, M. R. (2020). Basal stomatal aperture is regulated by GA-DELLAs in Arabidopsis. Journal of Plant Physiology, 250, Article 153182. https://doi.org/10.1016/j.jplph.2020.153182

Stomatal aperture is tightly regulated in order to achieve the best compromise between gas exchange and water conservation. Steady-state (basal) stomatal aperture is therefore understandably a key component in plant fitness. It has been shown previou... Read More about Basal stomatal aperture is regulated by GA-DELLAs in Arabidopsis.

Single-dose treatment for cutaneous leishmaniasis with an easily synthesized chalcone entrapped in polymeric microparticles (2020)
Journal Article
Sousa-Batista, A. J., Arruda-Costa, N., Escrivani, D. O., Reynaud, F., Steel, P. G., & Rossi-Bergmann, B. (2020). Single-dose treatment for cutaneous leishmaniasis with an easily synthesized chalcone entrapped in polymeric microparticles. Parasitology, 147(9), 1032-1037. https://doi.org/10.1017/s0031182020000712

Cutaneous leishmaniasis (CL) is a major health problem in many countries and its current treatment involves multiple parenteral injections with toxic drugs and requires intensive health services. Previously, the efficacy of a single subcutaneous inje... Read More about Single-dose treatment for cutaneous leishmaniasis with an easily synthesized chalcone entrapped in polymeric microparticles.

Exploiting C-H Borylation for the Multidirectional Elaboration of 2-Halopyridines (2019)
Journal Article
Reuven, J., Salih, O., Sadler, S., Thomas, C., & Steel, P. (2020). Exploiting C-H Borylation for the Multidirectional Elaboration of 2-Halopyridines. Tetrahedron, 76(3), Article 130836. https://doi.org/10.1016/j.tet.2019.130836

Regioselectively polysubstituted pyridines can be efficiently accessed from 2-halopyridines via a sequence involving C-H borylation, Suzuki-Miyaura cross-coupling and nucleophilic aromatic substitution chemistry.

Encapsulation in lipid-core nanocapsules improves topical treatment with the potent antileishmanial compound CH8 (2019)
Journal Article
Escrivani, D. O., Lopes, M. V., Poletto, F., Ferrarini, S. R., Sousa-Batista, A. J., Steel, P. G., …Rossi-Bergmann, B. (2020). Encapsulation in lipid-core nanocapsules improves topical treatment with the potent antileishmanial compound CH8. Nanomedicine: Nanotechnology, Biology and Medicine, 24, Article 102121. https://doi.org/10.1016/j.nano.2019.102121

Cutaneous leishmaniasis (CL) is a neglected parasitic disease conventionally treated by multiple injections with systemically toxic drugs. Aiming at a more acceptable therapy, we developed lipid-core nanocapsules (LNCs) entrapping the potent antileis... Read More about Encapsulation in lipid-core nanocapsules improves topical treatment with the potent antileishmanial compound CH8.

C-H activation/metalation approaches for the synthesis of indolizine derivatives (2019)
Journal Article
Clososki, G. C., Steel, P. G., Bertallo, C. R. D. S., Arroio, T. R. A. R., Vessecchi, R., Toledo, M. F., & Sadler, S. (2019). C-H activation/metalation approaches for the synthesis of indolizine derivatives. European Journal of Organic Chemistry, 31-32, 5205-5213. https://doi.org/10.1002/ejoc.201900608

The C‐H borylation of indolizines has not previously been reported and in this communication, we describe our preliminary efforts to apply this chemistry to this scaffold and contrast this approach to directed metalation. Through these methodologies... Read More about C-H activation/metalation approaches for the synthesis of indolizine derivatives.

Impact of heat and drought stress on peroxisome proliferation in quinoa (2019)
Journal Article
Hinojosa, L., Sanad, M., Jarvis, D., Steel, P., Murphy, K., & Smertenko, A. (2019). Impact of heat and drought stress on peroxisome proliferation in quinoa. The Plant Journal, 99(6), 1144-1158. https://doi.org/10.1111/tpj.14411

Although peroxisomes play a key role in plant metabolism under both normal and stressful growth conditions, the impact of drought and heat stress on the peroxisomes remains unknown. Quinoa represents an informative system for dissecting the impact of... Read More about Impact of heat and drought stress on peroxisome proliferation in quinoa.

Identification of Novel Benzoxa-[2,1,3]-diazole Substituted Amino Acid Hydrazides as Potential Anti-Tubercular Agents (2019)
Journal Article
Brown, A., Aljohani, A., Gill, J., Steel, P., & Sellars, J. (2019). Identification of Novel Benzoxa-[2,1,3]-diazole Substituted Amino Acid Hydrazides as Potential Anti-Tubercular Agents. Molecules, 24(4), Article 811. https://doi.org/10.3390/molecules24040811

Discovery and development of new therapeutic options for the treatment of Mycobacterium tuberculosis (Mtb) infection are desperately needed to tackle the continuing global burden of this disease and the efficacy and cost limitations associated with c... Read More about Identification of Novel Benzoxa-[2,1,3]-diazole Substituted Amino Acid Hydrazides as Potential Anti-Tubercular Agents.

Copper-Boryl Mediated Organic Synthesis (2018)
Journal Article
Hemming, D., Fritzemeier, R., Westcott, S. A., Santos, W. L., & Steel, P. G. (2018). Copper-Boryl Mediated Organic Synthesis. Chemical Society Reviews, 47(19), 7477-7494. https://doi.org/10.1039/c7cs00816c

Organoboron compounds are valuable synthetic intermediates that find application in a diverse variety of processes including both C–X and C–C bond-forming transformations. This has been achieved by using a variety of boron derivatives. Of these, boro... Read More about Copper-Boryl Mediated Organic Synthesis.

Identifying inhibitors of the Leishmania inositol phosphorylceramide synthase with antiprotozoal activity using a yeast-based assay and ultra-high throughput screening platform (2018)
Journal Article
Norcliffe, J., Mina, J., Alvarez-Ruiz, E., Cantizani-Perez, J., de Dios-Anton, F., Colmenarejo, G., …Denny, P. (2018). Identifying inhibitors of the Leishmania inositol phosphorylceramide synthase with antiprotozoal activity using a yeast-based assay and ultra-high throughput screening platform. Scientific Reports, 8, Article 3938. https://doi.org/10.1038/s41598-018-22063-9

Leishmaniasis is a Neglected Tropical Disease caused by the insect-vector borne protozoan parasite, Leishmania species. Infection affects millions of the world’s poorest, however vaccines are absent and drug therapy limited. Recently, public-private... Read More about Identifying inhibitors of the Leishmania inositol phosphorylceramide synthase with antiprotozoal activity using a yeast-based assay and ultra-high throughput screening platform.

Testing a chemical series inspired by plant stress oxylipin signalling agents for herbicide safening activity (2018)
Journal Article
Brazier-Hicks, M., Knight, K. M., Sellars, J. D., Steel, P. G., & Edwards, R. (2018). Testing a chemical series inspired by plant stress oxylipin signalling agents for herbicide safening activity. Pest Management Science, 74(4), 828-836. https://doi.org/10.1002/ps.4859

BACKGROUND Herbicide safening in cereals is linked to a rapid xenobiotic response (XR), involving the induction of glutathione transferases (GSTs). The XR is also invoked by oxidized fatty acids (oxylipins) released during plant stress, suggesting a... Read More about Testing a chemical series inspired by plant stress oxylipin signalling agents for herbicide safening activity.

Repurposing as a Strategy for the Discovery of New Anti-Leishmanials: The-State-of-the-Art (2017)
Journal Article
Charlton, R., Rossi-Bergmann, B., Denny, P. W., & Steel, P. G. (2018). Repurposing as a Strategy for the Discovery of New Anti-Leishmanials: The-State-of-the-Art. Parasitology, 145(2), 219-236. https://doi.org/10.1017/s0031182017000993

Leishmaniasis is a vector-borne neglected tropical disease caused by protozoan parasites of the genus Leishmania for which there is a paucity of effective viable non-toxic drugs. There are 1·3 million new cases each year causing considerable socio-ec... Read More about Repurposing as a Strategy for the Discovery of New Anti-Leishmanials: The-State-of-the-Art.

Impact of salt stress, cell death, and autophagy on peroxisomes: quantitative and morphological analyses using small Fluorescent probe N-BODIPY (2017)
Journal Article
Fahy, D., Sanad, M. N., Duscha, K., Lyons, M., Liu, F., Bozhkov, P., …Smertenko, A. (2017). Impact of salt stress, cell death, and autophagy on peroxisomes: quantitative and morphological analyses using small Fluorescent probe N-BODIPY. Scientific Reports, 7, Article 39069. https://doi.org/10.1038/srep39069

Plant peroxisomes maintain a plethora of key life processes including fatty acid β-oxidation, photorespiration, synthesis of hormones, and homeostasis of reactive oxygen species (ROS). Abundance of peroxisomes in cells is dynamic; however mechanisms... Read More about Impact of salt stress, cell death, and autophagy on peroxisomes: quantitative and morphological analyses using small Fluorescent probe N-BODIPY.

Zinc-Catalyzed Dual C–X and C–H Borylation of Aryl Halides (2015)
Journal Article
Bose, S. K., Deißenberger, A., Eichhorn, A., Steel, P. G., Lin, Z., & Marder, T. B. (2015). Zinc-Catalyzed Dual C–X and C–H Borylation of Aryl Halides. Angewandte Chemie International Edition, 54(40), 11843-11847. https://doi.org/10.1002/anie.201505603

A zinc-catalyzed combined C[BOND]X and C[BOND]H borylation of aryl halides using B2pin2 (pin=OCMe2CMe2O) to produce the corresponding 1,2-diborylarenes under mild conditions was developed. Catalytic C[BOND]H bond activation occurs ortho to the halide... Read More about Zinc-Catalyzed Dual C–X and C–H Borylation of Aryl Halides.

Multidirectional Synthesis of Substituted Indazoles via Iridium-Catalyzed C-H Borylation (2015)
Journal Article
Sadler, S., Hones, A., Roberts, B., Blakemore, D., Marder, T., & Steel, P. (2015). Multidirectional Synthesis of Substituted Indazoles via Iridium-Catalyzed C-H Borylation. Journal of Organic Chemistry, 80(10), 5308-5314. https://doi.org/10.1021/acs.joc.5b00452

In the absence of a steric directing group, iridium-catalyzed C–H borylation of N-protected indazoles occurs rapidly and selectively at C-3 and the resulting boronate esters can be utilized in a range of downstream conversions. The functional group t... Read More about Multidirectional Synthesis of Substituted Indazoles via Iridium-Catalyzed C-H Borylation.

Iridium-catalyzed C–H borylation of pyridines (2014)
Journal Article
Sadler, S., Tajuddin, H., Mkhalid, I., Batsanov, A., Albesa-Jove, D., Cheung, M., …Steel, P. (2014). Iridium-catalyzed C–H borylation of pyridines. Organic and Biomolecular Chemistry, 12(37), 7318-7327. https://doi.org/10.1039/c4ob01565g

The iridium-catalysed C–H borylation is a valuable and attractive method for the preparation of aryl and heteroaryl boronates. However, application of this methodology for the preparation of pyridyl and related azinyl boronates can be challenged by l... Read More about Iridium-catalyzed C–H borylation of pyridines.

The First Intramolecular Silene Diels-Alder Reactions (2014)
Journal Article
Czyzewski, M., Sellars, J., Guliashvili, T., Tibbelin, J., Johnstone, L., Bower, J., …Steel, P. (2014). The First Intramolecular Silene Diels-Alder Reactions. Chemical Communications, 50(22), 2919 - 2921. https://doi.org/10.1039/c3cc49526d

The synthesis of silaheterocycles through the first examples of an intramolecular silene Diels–Alder reaction is described.

Iridium-catalyzed C–H borylation of quinolines and unsymmetrical 1,2-disubstituted benzenes: insights into steric and electronic effects on selectivity (2012)
Journal Article
Tajuddin, H., Harrisson, P., Bitterlich, B., Collings, J., Sim, N., Batsanov, A., …Steel, P. (2012). Iridium-catalyzed C–H borylation of quinolines and unsymmetrical 1,2-disubstituted benzenes: insights into steric and electronic effects on selectivity. Chemical Science, 3(12), 3505-3515. https://doi.org/10.1039/c2sc20776a

The C-glycosylation of flavonoids in cereals (2009)
Journal Article
Brazier-Hicks, M., Evans, K., Gershater, M., Puschmann, H., Steel, P., & Edwards, R. (2009). The C-glycosylation of flavonoids in cereals. Journal of Biological Chemistry, 284(27), 17926-17934. https://doi.org/10.1074/jbc.m109.009258

Flavonoids normally accumulate in plants as O-glycosylated derivatives, but several species, including major cereal crops, predominantly synthesize flavone-C-glycosides, which are stable to hydrolysis and are biologically active both in planta and as... Read More about The C-glycosylation of flavonoids in cereals.

The Trypanosoma brucei sphingolipid synthase, an essential enzyme and drug target (2009)
Journal Article
Mina, J., Pan, S., Wansadhipathi, N., Bruce, C., Shams-Eldin, H., Schwarz, R., …Denny, P. (2009). The Trypanosoma brucei sphingolipid synthase, an essential enzyme and drug target. Molecular and Biochemical Parasitology, 168(1), 16-23. https://doi.org/10.1016/j.molbiopara.2009.06.002

Sphingolipids are important components of eukaryotic membranes, particularly the plasma membrane, and are involved in a diverse array of signal transduction processes. In the Eukaryota the biosynthetic pathway for the formation of these lipid species... Read More about The Trypanosoma brucei sphingolipid synthase, an essential enzyme and drug target.

Hosomi-Sakurai Reactions of Silacyclohexenes (2007)
Journal Article
Hughes, N., Pullin, R., Sanganee, M., Sellars, J., Steel, P., & Turner, M. (2007). Hosomi-Sakurai Reactions of Silacyclohexenes. Organic and Biomolecular Chemistry, 5(17), 2841-2848. https://doi.org/10.1039/b709318g

Silacyclic allyl silanes, derived from silene–diene Diels–Alder reactions, combine with acetals in the presence of Lewis acids to afford, following oxidation of the intermediate fluorosilane, either butane-1,4-diols or tetrahydronaphthalenes containi... Read More about Hosomi-Sakurai Reactions of Silacyclohexenes.

The dihydrofuran template approach to furofuran synthesis (2006)
Journal Article
Aldous, D., Batsanov, A., Yufit, D., Dalencon, A., Dutton, W., & Steel, P. (2006). The dihydrofuran template approach to furofuran synthesis. Organic and Biomolecular Chemistry, 4(15), 2912-2927. https://doi.org/10.1039/b604952d

Flash vacuum pyrrolysis of vinyl epoxides provides cis-dihydrofuran carboxylic esters in good yields and diastereoselectivities, which, on base-promoted epimerisation afford the complementary trans series. The compounds provide a viable template for... Read More about The dihydrofuran template approach to furofuran synthesis.

The oxanorbornene approach to 3-hydroxy, 3,4-dihydroxy and 3,4,5-trihydroxy derivatives of 2-aminocyclohexanecarboxylic acid (2006)
Journal Article
Masesane, I., Batsanov, A., Howard, J., Mondal, R., & Steel, P. (2006). The oxanorbornene approach to 3-hydroxy, 3,4-dihydroxy and 3,4,5-trihydroxy derivatives of 2-aminocyclohexanecarboxylic acid. Beilstein Journal of Organic Chemistry, 2(9), Article 9. https://doi.org/10.1186/1860-5397-2-9

The nitro oxanorbornene adduct derived from the Diels-Alder reaction of ethyl (E)-3-nitroacrylate and furan provides a versatile template for the stereoselective synthesis of hydroxylated derivatives of 2-aminocyclohexanecarboxylic acid (ACHC).

Hosomi-Sakurai reactions of silacyclic allyl silanes (2006)
Journal Article
Sellars, J., Steel, P., & Turner, M. (2006). Hosomi-Sakurai reactions of silacyclic allyl silanes. Chemical Communications, 2385-2387. https://doi.org/10.1039/b602642g

Substituted silacyclohexenes, generated through silene–diene [4 + 2] cycloaddition reactions, undergo Lewis acid promoted Sakurai type reactions with acetals to afford, following oxidation of the resultant fluorosilane, 1,4-diols with four contiguous... Read More about Hosomi-Sakurai reactions of silacyclic allyl silanes.

Unique Regulation of the Active site of the Serine Esterase S-Formylglutathione Hydrolase. (2006)
Journal Article
Cummins, I., McAuley, K., Fordham-Skelton, A., Schwoerer, R., Steel, P. G., Davis, B. G., & Edwards, R. (2006). Unique Regulation of the Active site of the Serine Esterase S-Formylglutathione Hydrolase. Journal of Molecular Biology, 359(2), 422-432. https://doi.org/10.1016/j.jmb.2006.03.048

S-Formylglutathione hydrolases (SFGHs) are highly conserved thioesterases present in prokaryotes and eukaryotes, and form part of the formaldehyde detoxification pathway, as well as functioning as xenobiotic-hydrolysing carboxyesterases. As defined b... Read More about Unique Regulation of the Active site of the Serine Esterase S-Formylglutathione Hydrolase..

Diversity linker units for solid-phase organic synthesis. (2006)
Journal Article
Scott, P., & Steel, P. (2006). Diversity linker units for solid-phase organic synthesis. European Journal of Organic Chemistry, 2006(10), 2251-2268. https://doi.org/10.1002/ejoc.200500804

In recent years an ever-increasing number of traditional solution-phase reactions have been adapted for solid-phase organic synthesis (SPOS) because of the ease of application of solid-phase techniques to combinatorial chemistry and high-throughput s... Read More about Diversity linker units for solid-phase organic synthesis..

Silylenes, silenes, and disilenes: Novel silicon-based reagents for organic synthesis? (2006)
Journal Article
Steel, P., & Ottosson, H. (2006). Silylenes, silenes, and disilenes: Novel silicon-based reagents for organic synthesis?. Chemistry - A European Journal, 12(6), 1576-1585. https://doi.org/10.1002/chem.200500429

Silylenes, silenes, and disilenes are silicon analogues of carbenes and alkenes. Since the first detection and isolation of these species a few decades ago, focus has been given to their fundamental structure and reactivity properties. Recent develop... Read More about Silylenes, silenes, and disilenes: Novel silicon-based reagents for organic synthesis?.

Polymer supported palladium N-heterocyclic carbene complexes: long lived recyclable catalysts for cross coupling reactions (2004)
Journal Article
Steel, P., & Teasdale, C. (2004). Polymer supported palladium N-heterocyclic carbene complexes: long lived recyclable catalysts for cross coupling reactions. Tetrahedron Letters, 45(49), 8977-8980. https://doi.org/10.1016/j.tetlet.2004.10.061

Polyrner supported palladium complexes, containing a pyridyl bis N-heterocyclic carbene ligand system derived from isonicotinic acid, provide highly stable catalysts for Heck and Suzuki cross coupling reactions. These heterogenous catalysts can be re... Read More about Polymer supported palladium N-heterocyclic carbene complexes: long lived recyclable catalysts for cross coupling reactions.

A simple solid phase diversity linker strategy using enol phosphonates (2004)
Journal Article
Campbell, I., Guo, J., Jones, E., & Steel, P. (2004). A simple solid phase diversity linker strategy using enol phosphonates. Organic and Biomolecular Chemistry, 2(19), 2725-2727. https://doi.org/10.1039/b411111g

Polymer bound lactam enol phosphonates can be easily generated using simple phenol on polystyrene resin. These stable, storable compounds can be released in a diversity cleavage strategy, using Suzuki cross coupling conditions, to provide 2-arylenami... Read More about A simple solid phase diversity linker strategy using enol phosphonates.

Stereochemistry of the reaction of Si-phenyl silenes with butadienes: elaboration of the silacycloadducts to provide a novel route to substituted lactones (2004)
Journal Article
Sanganee, M., Steel, P., & Whelligan, D. (2004). Stereochemistry of the reaction of Si-phenyl silenes with butadienes: elaboration of the silacycloadducts to provide a novel route to substituted lactones. Organic and Biomolecular Chemistry, 2(16), 2393-2402. https://doi.org/10.1039/b404175e

Silenes generated through a silyl-modified Peterson olefination procedure can be trapped with a range of alkyl butadienes via a [4+2] cycloaddition pathway to afford silacycles accompanied by variable amounts of competing ene, [2+2] and silene dimer... Read More about Stereochemistry of the reaction of Si-phenyl silenes with butadienes: elaboration of the silacycloadducts to provide a novel route to substituted lactones.