David Parker's Outputs (11)

Enantioselective cellular localisation of europium(iii) coordination complexes (2017)
Journal Article
Frawley, A. T., Linford, H., Starck, M., Pal, R., & Parker, D. (2018). Enantioselective cellular localisation of europium(iii) coordination complexes. Chemical Science, 9(4), 1042-1049. https://doi.org/10.1039/c7sc04422d

The selective mitochondrial localisation of the Λ enantiomer of three different emissive europium(III) complexes in NIH 3T3 and MCF7 cells contrasts with the behaviour of the Δ enantiomer, for which a predominant lysosomal localisation was observed b... Read More about Enantioselective cellular localisation of europium(iii) coordination complexes.

Solvent polarity and oxygen sensitivity, rather than viscosity, determine lifetimes of biaryl-sensitised terbium luminescence (2017)
Journal Article
Walter, E. R., Williams, J. G., & Parker, D. (2017). Solvent polarity and oxygen sensitivity, rather than viscosity, determine lifetimes of biaryl-sensitised terbium luminescence. Chemical Communications, 53(100), 13344-13347. https://doi.org/10.1039/c7cc08361k

In a macrocyclic terbium complex incorporating a biaryl sensitiser, the observed variation of emission lifetime is shown to be determined by the solubility of oxygen in the solvent system and the relative energy of the chromophore excited state, rath... Read More about Solvent polarity and oxygen sensitivity, rather than viscosity, determine lifetimes of biaryl-sensitised terbium luminescence.

Rationalization of Anomalous Pseudocontact Shifts and Their Solvent Dependence in a Series of C3-Symmetric Lanthanide Complexes (2017)
Journal Article
Vonci, M., Mason, K., Suturina, E. A., Frawley, A. T., Worswick, S. G., Kuprov, I., …Chilton, N. F. (2017). Rationalization of Anomalous Pseudocontact Shifts and Their Solvent Dependence in a Series of C3-Symmetric Lanthanide Complexes. Journal of the American Chemical Society, 139(40), 14166-14172. https://doi.org/10.1021/jacs.7b07094

Bleaney’s long-standing theory of magnetic anisotropy has been employed with some success for many decades to explain paramagnetic NMR pseudocontact shifts, and has been the subject of many subsequent approximations. Here, we present a detailed exper... Read More about Rationalization of Anomalous Pseudocontact Shifts and Their Solvent Dependence in a Series of C3-Symmetric Lanthanide Complexes.

Beyond Bleaney's Theory: Experimental and Theoretical Analysis of Periodic Trends in Lanthanide Induced Chemical Shift (2017)
Journal Article
Parker, D., Kuprov, I., Suturina, E., Mason, K., & Geraldes, C. (2017). Beyond Bleaney's Theory: Experimental and Theoretical Analysis of Periodic Trends in Lanthanide Induced Chemical Shift. Angewandte Chemie International Edition, 56(40), 12215-12218. https://doi.org/10.1002/anie.201706931

A detailed analysis of paramagnetic NMR shifts in a series of isostructural lanthanide complexes relavant to PARASHIFT contrast agents reveals unexpected trends in the magnetic susceptibility anisotropy that cannot be explained by the commonly used B... Read More about Beyond Bleaney's Theory: Experimental and Theoretical Analysis of Periodic Trends in Lanthanide Induced Chemical Shift.

Equilibrium, Kinetic and Structural Properties of Gallium(III) and Some Divalent Metal Complexes Formed with the New DATAm and DATA5m Ligands (2017)
Journal Article
Farkas, E., Nagel, J., Waldron, B. P., Parker, D., Tóth, I., Brücher, E., …Baranyai, Z. (2017). Equilibrium, Kinetic and Structural Properties of Gallium(III) and Some Divalent Metal Complexes Formed with the New DATAm and DATA5m Ligands. Chemistry - A European Journal, 23(43), 10358-10371. https://doi.org/10.1002/chem.201701508

The development of 68Ge/68Ga generators has made the positron-emitting 68Ga isotope widely accessible and raised interest in new chelate complexes of Ga3+. The hexadentate 1,4-di(acetate)-6-methyl[amino(methyl)acetate]perhydro-1,4-diazepane (DATAm) l... Read More about Equilibrium, Kinetic and Structural Properties of Gallium(III) and Some Divalent Metal Complexes Formed with the New DATAm and DATA5m Ligands.

Responsive, Water-Soluble Europium(III) Luminescent Probes (2017)
Journal Article
Shuvaev, S., Starck, M., & Parker, D. (2017). Responsive, Water-Soluble Europium(III) Luminescent Probes. Chemistry - A European Journal, 23(42), 9974-9989. https://doi.org/10.1002/chem.201700567

The design principles, mechanism of action and performance of europium(III) complexes that serve as strongly emissive and responsive molecular probes in water are critically discussed. Examples of systems designed to assess pH, selected metal ions an... Read More about Responsive, Water-Soluble Europium(III) Luminescent Probes.

Selectively switching on europium emission in drug site one of human serum albumin (2017)
Journal Article
Shuvaev, S., Pal, R., & Parker, D. (2017). Selectively switching on europium emission in drug site one of human serum albumin. Chemical Communications, 53(50), 6724-6727. https://doi.org/10.1039/c7cc03071a

A luminescent europium probe has been discovered that binds selectively to drug-site I in human serum albumin, signalled by a ‘switching on’ of europium emission, and accompanied by strong induced circularly polarised luminescence.

Simultaneous Triple Imaging with Two PARASHIFT Probes: Encoding Anatomical, pH and Temperature Information using Magnetic Resonance Shift Imaging (2017)
Journal Article
Finney, K. N., Harnden, A. C., Rogers, N. J., Senanayake, P. K., Blamire, A. M., O'Hogain, D., & Parker, D. (2017). Simultaneous Triple Imaging with Two PARASHIFT Probes: Encoding Anatomical, pH and Temperature Information using Magnetic Resonance Shift Imaging. Chemistry - A European Journal, 23(33), 7976-7989. https://doi.org/10.1002/chem.201700447

The chemical shift of paramagnetically shifted resonances in lanthanide(III) complexes encodes information about temperature and has also been made to report pH in parallel, through introduction of a single phosphonate group adjacent to the reporter... Read More about Simultaneous Triple Imaging with Two PARASHIFT Probes: Encoding Anatomical, pH and Temperature Information using Magnetic Resonance Shift Imaging.

PARASHIFT Probes: Solution NMR and X-ray Structural Studies of Macrocyclic Ytterbium and Yttrium Complexes (2017)
Journal Article
Mason, K., Rogers, N., Suturina, E., Kuprov, I., Aguilar, J., Batsanov, A., …Parker, D. (2017). PARASHIFT Probes: Solution NMR and X-ray Structural Studies of Macrocyclic Ytterbium and Yttrium Complexes. Inorganic Chemistry, 56(7), 4028-4038. https://doi.org/10.1021/acs.inorgchem.6b02291

Ytterbium and yttrium complexes of octadentate ligands based on 1,4,7,10-tetraazacyclododecane with a coordinated pyridyl group and either tricarboxylate (L1) or triphosphinate (L2) donors form twisted-square-antiprismatic structures. The former crys... Read More about PARASHIFT Probes: Solution NMR and X-ray Structural Studies of Macrocyclic Ytterbium and Yttrium Complexes.

Selective signalling of sialic acid in solution by circularly polarised luminescence spectroscopy using a dynamically racemic europium(III) complex (2017)
Journal Article
Neil, E., & Parker, D. (2017). Selective signalling of sialic acid in solution by circularly polarised luminescence spectroscopy using a dynamically racemic europium(III) complex. RSC Advances, 7(8), 4531-4540. https://doi.org/10.1039/c6ra26662b

A europium complex bearing a phenylboronic acid group has been created that binds reversibly in methanol to sialic acid and lactic acid, as signalled by changes in the Eu total emission spectrum and the induction of strong circularly polarised lumine... Read More about Selective signalling of sialic acid in solution by circularly polarised luminescence spectroscopy using a dynamically racemic europium(III) complex.

Induced Europium Circularly Polarised Luminescence Monitors Reversible Drug Binding to Native α1-Acid Glycoprotein (2017)
Journal Article
Jennings, L., Waters, R., Pal, R., & Parker, D. (2017). Induced Europium Circularly Polarised Luminescence Monitors Reversible Drug Binding to Native α1-Acid Glycoprotein. ChemMedChem, 12(3), 271-277. https://doi.org/10.1002/cmdc.201600571

Alpha-1-acid glycoprotein (α1-AGP) is an important blood plasma glycoprotein. Following an acute-phase reaction such as stress, inflammation, burn, or infection, the bloodstream concentration of α1-AGP can increase up to 400 % of its normal concentra... Read More about Induced Europium Circularly Polarised Luminescence Monitors Reversible Drug Binding to Native α1-Acid Glycoprotein.