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David Parker's Outputs (128)

NMR and luminescence binding studies of ytterbium, thulium, and europium macrocyclic complexes with phosphorus(V) oxy anions (2005)
Journal Article
Atkinson, P., Bretonniere, Y., Parker, D., & Muller, G. (2005). NMR and luminescence binding studies of ytterbium, thulium, and europium macrocyclic complexes with phosphorus(V) oxy anions. Helvetica Chimica Acta, 88(3), 391-405

The binding of a series of phosphate anions to coordinatively unsaturated macrocyclic complexes of Yb, Tm, and Eu was studied by H-1-NMR, emission and circularly polarized luminescence (CPL) spectroscopy. Each ternary adduct was distinguished by its... Read More about NMR and luminescence binding studies of ytterbium, thulium, and europium macrocyclic complexes with phosphorus(V) oxy anions.

Synthesis of a europium complex for anion-sensing involving regioselective substitution of cyclen (2005)
Journal Article
Yu, J., & Parker, D. (2005). Synthesis of a europium complex for anion-sensing involving regioselective substitution of cyclen. European Journal of Organic Chemistry, 2005(20), 4249-4252. https://doi.org/10.1002/ejoc.200500432

A regioselective synthetic route that allows the construction of tri-functionally substituted cyclen is described. This facilitates the synthesis of a europium complex that exhibits a good photoresponse to malate, forming the basis of a chemoselectiv... Read More about Synthesis of a europium complex for anion-sensing involving regioselective substitution of cyclen.

Synthesis and characterisation of highly emissive and kinetically stable lanthanide complexes suitable for usage 'in cellulo' (2005)
Journal Article
Poole, R., Bobba, G., Cann, M., Frias, J., Parker, D., & Peacock, R. (2005). Synthesis and characterisation of highly emissive and kinetically stable lanthanide complexes suitable for usage 'in cellulo'. Organic and Biomolecular Chemistry, 3(6), 1013-1024. https://doi.org/10.1039/b418964g

The synthesis and photophysical characterisation are reported of a series of cationic, neutral and anionic europium and terbium complexes based on structurally related, nonadentate ligands based on the cyclen macrocycle. Each complex incorporates a t... Read More about Synthesis and characterisation of highly emissive and kinetically stable lanthanide complexes suitable for usage 'in cellulo'.

The DNA sequence of the human X chromosome (2005)
Journal Article
Ross, M. T., Grafham, D. V., Coffey, A. J., Scherer, S., McLay, K., Muzny, D., Platzer, M., Howell, G. R., Burrows, C., Bird, C. P., Frankish, A., Lovell, F. L., Howe, K. L., Ashurst, J. L., Fulton, R. S., Sudbrak, R., Wen, G. P., Jones, M. C., Hurles, M. E., Andrews, T. D., …Parker, D. (2005). The DNA sequence of the human X chromosome. Nature, 434(7031), 325-337

The human X chromosome has a unique biology that was shaped by its evolution as the sex chromosome shared by males and females. We have determined 99.3% of the euchromatic sequence of the X chromosome. Our analysis illustrates the autosomal origin of... Read More about The DNA sequence of the human X chromosome.

Efficient relaxivity enhancement in dendritic gadolinium complexes: effective motional coupling in medium molecular weight conjugates (2004)
Journal Article
Fulton, D., O'Halloran, M., Parker, D., Senanayake, K., Botta, M., & Aime, S. (2005). Efficient relaxivity enhancement in dendritic gadolinium complexes: effective motional coupling in medium molecular weight conjugates. Chemical Communications, 2005(4), 474-476. https://doi.org/10.1039/B413536A

Enhancement of the relaxivities of Gd-based MRI contrast agents is achieved by placing the metal ion at the barycentre of the molecular complex in order to improve motional coupling.

NMR and chiroptical examination of the diastereoisomers of (S)-Eu-EOB-DTPA (2004)
Journal Article
Thompson, N., Parker, D., Schmitt-Willich, H., Sulzle, D., Muller, G., & Riehl, J. (2004). NMR and chiroptical examination of the diastereoisomers of (S)-Eu-EOB-DTPA. Dalton Transactions, 1892-1895. https://doi.org/10.1039/B403863K

The solution structure of the diastereoisomers of (S)-Eu-EOB-DTPA has been analysed by H-1 NMR, CD and CPL spectroscopy. Two major species exist which possess very similar 1H NMR paramagnetic shifts and emission spectra, consistent with a 9-coordinat... Read More about NMR and chiroptical examination of the diastereoisomers of (S)-Eu-EOB-DTPA.

Design, synthesis and evaluation of ratiometric probes for hydrogencarbonate based on europium emission (2004)
Journal Article
Bretonniere, Y., Cann, M., Parker, D., & Slater, R. (2004). Design, synthesis and evaluation of ratiometric probes for hydrogencarbonate based on europium emission. Organic and Biomolecular Chemistry, 2(11), 1624-1632. https://doi.org/10.1039/b400734b

A series of cationic, zwitterionic and anionic macrocyclic europium complexes has been prepared incorporating a N or C- linked acridone chromophore that allows sensitisation of Eu emission following excitation at 390-410nm. Each of these complexes se... Read More about Design, synthesis and evaluation of ratiometric probes for hydrogencarbonate based on europium emission.

Steric control of lanthanide hydration state: fast water exchange at gadolinium in a mono-amide 'DOTA' complex (2004)
Journal Article
Congreve, A., Parker, D., Gianolio, E., & Botta, M. (2004). Steric control of lanthanide hydration state: fast water exchange at gadolinium in a mono-amide 'DOTA' complex. Dalton Transactions, 2004(9), 1441-1445. https://doi.org/10.1039/B402230K

Detailed analyses of the solution structure and exchange dynamics of two sets of homologous mono-amide triacetate lanthanide complexes (Ln = Eu, Gd) of cyclen have been undertaken. The complex [LnL(1)], bearing an N-linked CH2CH2NHCO-pyridyl moiety,... Read More about Steric control of lanthanide hydration state: fast water exchange at gadolinium in a mono-amide 'DOTA' complex.

Excitement in f block : structure, dynamics and function of nine-coordinate chiral lanthanide complexes in aqueous media (2004)
Journal Article
Parker, D. (2004). Excitement in f block : structure, dynamics and function of nine-coordinate chiral lanthanide complexes in aqueous media. Chemical Society Reviews, 33(3), 156-165. https://doi.org/10.1039/b311001j

Lanthanide complexation chemistry has been studied intensively over the past 15 years and progress has been stimulated by the advent of well-defined, kinetically robust systems tailored to applications as bioactive probes for magnetic resonance and l... Read More about Excitement in f block : structure, dynamics and function of nine-coordinate chiral lanthanide complexes in aqueous media.

Structural analysis of nine-coordinate lanthanide complexes: Steric control of the metal-water distance across the series (2003)
Journal Article
Parker, D., Puschmann, H., Batsanov, A., & Senanayake, K. (2003). Structural analysis of nine-coordinate lanthanide complexes: Steric control of the metal-water distance across the series. Inorganic Chemistry, 42(26), 8646-8651

The structures of 10 isomorphous lanthanide (Ln) complexes of a chiral DOTA tetra-amide ligand (L-1), [LnL(1)(H2O)](CF3-SO3)(3).3H(2)O, crystallizing in space group P2(1), have been studied by single-crystal X-ray diffraction. The Ln coordination is... Read More about Structural analysis of nine-coordinate lanthanide complexes: Steric control of the metal-water distance across the series.

Luminescent nonacoordinate cationic lanthanide complexes as potential cellular imaging and reactive probes (2003)
Journal Article
Frias, J., Bobba, G., Cann, M., Hutchison, C., & Parker, D. (2003). Luminescent nonacoordinate cationic lanthanide complexes as potential cellular imaging and reactive probes. Organic and Biomolecular Chemistry, 1(6), 905-907

Nonacoordinate Delta- and Lambda-Eu and Tb complexes have been tested as imaging and reactive probes in mouse fibroblast (NIH 3T3) cells. The uptake of these complexes by the cells was assessed by fluorescence microscopy. Complex-induced DNA damage w... Read More about Luminescent nonacoordinate cationic lanthanide complexes as potential cellular imaging and reactive probes.

The synthesis and characterisation of amphiphilic alpha,alpha-linked sexithiophenes with substituents at the terminal alpha-positions (2003)
Journal Article
Henze, O., Parker, D., & Feast, W. (2003). The synthesis and characterisation of amphiphilic alpha,alpha-linked sexithiophenes with substituents at the terminal alpha-positions. Journal of materials chemistry, 13(6), 1269-1273

A series of polydisperse amphiphilic alpha,alpha-linked sexithiophenes with an oligoethylene oxide substituent at one terminal alpha-position and a hydrogen atom or a hexyl group at the other have been synthesised via Stille and Suzuki cross coupling... Read More about The synthesis and characterisation of amphiphilic alpha,alpha-linked sexithiophenes with substituents at the terminal alpha-positions.

Examination of cobalt, nickel, copper and zinc(II) complex geometry and binding affinity in aqueous media using simple pyridylsulfonamide ligands (2003)
Journal Article
Congreve, A., Kataky, R., Knell, M., Parker, D., Puschmann, H., Senanayake, K., & Wylie, L. (2003). Examination of cobalt, nickel, copper and zinc(II) complex geometry and binding affinity in aqueous media using simple pyridylsulfonamide ligands. New Journal of Chemistry, 27(1), 98-106

The sixteen neutral ML2 complexes of Co, Ni, Cu and Zn(II) with the p-toluenesulfonamide and trifluoromethylsulfonamide derivatives of 2-aminomethylpyridine (L-1, L-2) and its 6-Me homologue (L-3, L-4) have been characterised by low temperature X-ray... Read More about Examination of cobalt, nickel, copper and zinc(II) complex geometry and binding affinity in aqueous media using simple pyridylsulfonamide ligands.

Structural and NMR investigations of the ternary adducts of twenty α-amino acids and selected dipeptides with a chiral, diaqua-ytterbium complex (2003)
Journal Article
Dickins, R., Batsanov, A., Howard, J., Parker, D., Puschmann, H., & Salamano, S. (2004). Structural and NMR investigations of the ternary adducts of twenty α-amino acids and selected dipeptides with a chiral, diaqua-ytterbium complex. Dalton Transactions, 2004(1), 70-80. https://doi.org/10.1039/b311791j

A detailed investigation of the nature of the binding of each of the 20 common alpha-amino acids and various selected dipeptides to a chiral, diaqua-ytterbium complex in aqueous solution has been carried out. Analysis of the dipolar H-1 NMR paramagne... Read More about Structural and NMR investigations of the ternary adducts of twenty α-amino acids and selected dipeptides with a chiral, diaqua-ytterbium complex.

Ternary complexes between cationic Gd-III chelates and anionic metabolites in aqueous solution: An NMR relaxometric study (2003)
Journal Article
Botta, M., Aime, S., Barge, A., Bobba, G., Dickins, R., Parker, D., & Terreno, E. (2003). Ternary complexes between cationic Gd-III chelates and anionic metabolites in aqueous solution: An NMR relaxometric study. Chemistry - A European Journal, 9(9), 2102-2109

The H-1 and O-17 NMR relaxometric properties of two cationic complexes formed by Gd-III with a macrocyclic heptadentate triamide ligand, L-1, and its N-methylated analogue, L-2, have been investigated in aqueous media as a function of pH, temperature... Read More about Ternary complexes between cationic Gd-III chelates and anionic metabolites in aqueous solution: An NMR relaxometric study.

Enantiopure lanthanide complexes incorporating a tetraazatriphenylene sensitiser and three naphthyl groups: exciton coupling, intramolecular energy transfer, efficient singlet oxygen formation and perturbation by DNA binding (2003)
Journal Article
Bobba, G., Bretonniere, Y., Frias, J., & Parker, D. (2003). Enantiopure lanthanide complexes incorporating a tetraazatriphenylene sensitiser and three naphthyl groups: exciton coupling, intramolecular energy transfer, efficient singlet oxygen formation and perturbation by DNA binding. Organic and Biomolecular Chemistry, 1(11), 1870-1872

In cationic nine-coordinate chiral terbium and europium complexes incorporating exciton-coupled naphthyl groups and a tetraazatriphenylene sensitising chromophore, efficient intramolecular energy transfer occurs leading to population of the naphthyl... Read More about Enantiopure lanthanide complexes incorporating a tetraazatriphenylene sensitiser and three naphthyl groups: exciton coupling, intramolecular energy transfer, efficient singlet oxygen formation and perturbation by DNA binding.

Temperature and pressure dependence of excitation spectra as a probe of the solution structure and equilibrium thermodynamics of a Eu(III) complex containing a modified dota ligand (2002)
Journal Article
Muller, G., Kean, S., Parker, D., & Riehl, J. (2002). Temperature and pressure dependence of excitation spectra as a probe of the solution structure and equilibrium thermodynamics of a Eu(III) complex containing a modified dota ligand. The Journal of Physical Chemistry A, 106(51), 12349-12355

The temperature and pressure dependence of the F-7(0) --> D-5(0) and F-7(1) --> D-5(0) excitation spectra for aqueous solutions of Eu(III) with race mic-tetra(alpha-carboxyethyl)DOTA have been measured. Individual excitation and emission peaks have b... Read More about Temperature and pressure dependence of excitation spectra as a probe of the solution structure and equilibrium thermodynamics of a Eu(III) complex containing a modified dota ligand.

Sol gel-immobilised terbium complexes for luminescent sensing of dissolved oxygen by analysis of emission decay (2002)
Journal Article
Blair, S., Kataky, R., & Parker, D. (2002). Sol gel-immobilised terbium complexes for luminescent sensing of dissolved oxygen by analysis of emission decay. New Journal of Chemistry, 26(5), 530-535

Cationic terbium complexes bearing an N-methylphenanthridinium chromophore have been incorporated in sol gel thin films and their response characteristics analysed with respect to variations in dissolved oxygen concentration. Analysis of the emission... Read More about Sol gel-immobilised terbium complexes for luminescent sensing of dissolved oxygen by analysis of emission decay.

Structural, luminescence, and NMR studies of the reversible binding of acetate, lactate, citrate, and selected amino acids to chiral diaqua ytterbium, gadolinium, and europium complexes (2002)
Journal Article
Dickins, R., Aime, S., Batsanov, A., Beeby, A., Botta, M., Bruce, J., …Puschmann, H. (2002). Structural, luminescence, and NMR studies of the reversible binding of acetate, lactate, citrate, and selected amino acids to chiral diaqua ytterbium, gadolinium, and europium complexes. Journal of the American Chemical Society, 124(43), 12697-12705. https://doi.org/10.1021/ja020836x

The nature of the ternary complexes formed in aqueous media at ambient pH on reversible binding of acetate, lactate, citrate, and selected amino acids and peptides to chiral diaqua europium, gadolinium, or ytterbium cationic complexes has been examin... Read More about Structural, luminescence, and NMR studies of the reversible binding of acetate, lactate, citrate, and selected amino acids to chiral diaqua ytterbium, gadolinium, and europium complexes.