Dr Gary Sharples' Outputs (2)

The X philes: structure-specific endonucleases that resolve Holliday junctions. (2001)
Journal Article
Sharples, G. (2001). The X philes: structure-specific endonucleases that resolve Holliday junctions. Molecular Microbiology, 39, 823-834. https://doi.org/10.1046/j.1365-2958.2001.02284.x

Genetic recombination is a critical cellular process that promotes evolutionary diversity, facilitates DNA repair and underpins genome duplication. It entails the reciprocal exchange of single strands between homologous DNA duplexes to form a four-wa... Read More about The X philes: structure-specific endonucleases that resolve Holliday junctions..

Genetic analysis of an archaeal Holliday junction resolvase in Escherichia coli. (2001)
Journal Article
Bolt, E., Lloyd, R., & Sharples, G. (2001). Genetic analysis of an archaeal Holliday junction resolvase in Escherichia coli. Journal of Molecular Biology, 310(3), 577-589

The study of genes and proteins in heterologous model systems provides a powerful approach to the analysis of common processes in biology. Here, we show how the bacterium Escherichia coli can be exploited to analyse genetically and biochemically the... Read More about Genetic analysis of an archaeal Holliday junction resolvase in Escherichia coli..