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Dr Keith Andrews' Outputs (3)

Enzyme-like Acyl Transfer Catalysis in a Bifunctional Organic Cage (2024)
Journal Article
Andrews, K. G., Piskorz, T. K., Horton, P. N., & Coles, S. J. (2024). Enzyme-like Acyl Transfer Catalysis in a Bifunctional Organic Cage. Journal of the American Chemical Society, 146(26), 17887-17897. https://doi.org/10.1021/jacs.4c03560

Amide-based organic cage cavities are, in principle, ideal enzyme active site mimics. Yet, cage-promoted organocatalysis has remained elusive, in large part due to synthetic accessibility of robust and functional scaffolds. Herein, we report the acyl... Read More about Enzyme-like Acyl Transfer Catalysis in a Bifunctional Organic Cage.

Exploration of the polymorphic solid-state landscape of an amide-linked organic cage using computation and automation (2024)
Journal Article
Shields, C. E., Fellowes, T., Slater, A. G., Cooper, A., Andrews, K. G., & Szczypiński, F. T. (2024). Exploration of the polymorphic solid-state landscape of an amide-linked organic cage using computation and automation. Chemical Communications, 60(47), 6023-6026. https://doi.org/10.1039/d4cc01407c

Organic cages can possess complex, functionalised cavities that make them promising candidates for synthetic enzyme mimics. Conformationally flexible, chemically robust structures are needed for adaptable guest binding and catalysis, but rapidly exch... Read More about Exploration of the polymorphic solid-state landscape of an amide-linked organic cage using computation and automation.

Programmable synthesis of organic cages with reduced symmetry (2024)
Journal Article
Andrews, K. G., Horton, P. N., & Coles, S. J. (2024). Programmable synthesis of organic cages with reduced symmetry. Chemical Science, 15(17), 6536-6543. https://doi.org/10.1039/d4sc00889h

Integrating symmetry-reducing methods into self-assembly methodology is desirable to efficiently realise the full potential of molecular cages as hosts and catalysts. Although techniques have been explored for metal organic (coordination) cages, rati... Read More about Programmable synthesis of organic cages with reduced symmetry.