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Glycan–glycan interactions determine Leishmania attachment to the midgut of permissive sand fly vectors (2020)
Journal Article
Hall, A. R., Blakeman, J. T., Eissa, A. M., Chapman, P., Morales-García, A. L., Stennett, L., Martin, O., Giraud, E., Dockrell, D. H., Cameron, N. R., Wiese, M., Yakob, L., Rogers, M. E., & Geoghegan, M. (2020). Glycan–glycan interactions determine Leishmania attachment to the midgut of permissive sand fly vectors. Chemical Science, 11(40), 10973-10983. https://doi.org/10.1039/d0sc03298k

Direct glycan–glycan interactions are increasingly implicated in survival and pathogenicity of bacteria. Here, we show that they can be exploited by protozoan parasites in their insect hosts. Force spectroscopy revealed that Leishmania promastigotes... Read More about Glycan–glycan interactions determine Leishmania attachment to the midgut of permissive sand fly vectors.

Giant Polymersome Protocells Dock with Virus Particle Mimics via Multivalent Glycan-Lectin Interactions (2016)
Journal Article
Kubilis, A., Abdulkarima, A., Eissa, A. M., & Cameron, N. R. (2016). Giant Polymersome Protocells Dock with Virus Particle Mimics via Multivalent Glycan-Lectin Interactions. Scientific Reports, 6, Article 32414. https://doi.org/10.1038/srep32414

Despite the low complexity of their components, several simple physical systems, including microspheres, coacervate droplets and phospholipid membrane structures (liposomes), have been suggested as protocell models. These, however, lack key cellular... Read More about Giant Polymersome Protocells Dock with Virus Particle Mimics via Multivalent Glycan-Lectin Interactions.

Glycosylated nanoparticles as efficient antimicrobial delivery agents (2016)
Journal Article
Eissa, A., Abdulkarim, A., Sharples, G., & Cameron, N. (2016). Glycosylated nanoparticles as efficient antimicrobial delivery agents. Biomacromolecules, 17(8), 2672-2679. https://doi.org/10.1021/acs.biomac.6b00711

Synthetic polymer nanoparticles that can be tailored through multivalent ligand display on the surface, while at the same time allowing encapsulation of desired bioactive molecules, are especially useful in providing a versatile and robust platform i... Read More about Glycosylated nanoparticles as efficient antimicrobial delivery agents.

Noncovalent PEGylation via Lectin–Glycopolymer Interactions (2016)
Journal Article
Antonik, P., Eissa, A., Round, A., Cameron, N., & Crowley, P. (2016). Noncovalent PEGylation via Lectin–Glycopolymer Interactions. Biomacromolecules, 17(8), 2719-2725. https://doi.org/10.1021/acs.biomac.6b00766

PEGylation, the covalent modification of proteins with polyethylene glycol, is an abundantly used technique to improve the pharmacokinetics of therapeutic proteins. The drawback with this methodology is that the covalently attached PEG can impede the... Read More about Noncovalent PEGylation via Lectin–Glycopolymer Interactions.

The preparation of graft copolymers of cellulose and cellulose derivatives using ATRP under homogeneous reaction conditions (2014)
Journal Article
Joubert, F., Musa, O. M., Hodgson, D. R., & Cameron, N. R. (2014). The preparation of graft copolymers of cellulose and cellulose derivatives using ATRP under homogeneous reaction conditions. Chemical Society Reviews, 43(20), 7217-7235. https://doi.org/10.1039/c4cs00053f

In this comprehensive review, we report on the preparation of graft-copolymers of cellulose and cellulose derivatives using atom transfer radical polymerization (ATRP) under homogeneous conditions. The review is divided into four sections according t... Read More about The preparation of graft copolymers of cellulose and cellulose derivatives using ATRP under homogeneous reaction conditions.

Amine-functionalization of glycidyl methacrylate-containing emulsion-templated porous polymers and immobilization of proteinase K for biocatalysis (2014)
Journal Article
Kimmins, S. D., Wyman, P., & Cameron, N. R. (2014). Amine-functionalization of glycidyl methacrylate-containing emulsion-templated porous polymers and immobilization of proteinase K for biocatalysis. Polymer, 55(1), 416-425. https://doi.org/10.1016/j.polymer.2013.09.019

Glycidyl methacrylate (GMA) emulsion-templated porous polymers (polyHIPEs) were prepared by thermal and photopolymerisation and derivatised with morpholine, tris(2-aminoethylamine) and a bisamino-PEG homobifunctional molecule. The extent of the funct... Read More about Amine-functionalization of glycidyl methacrylate-containing emulsion-templated porous polymers and immobilization of proteinase K for biocatalysis.

Galactose-Functionalized PolyHIPE Scaffolds for Use in Routine Three Dimensional Culture of Mammalian Hepatocytes (2013)
Journal Article
Hayward, A., Eissa, A., Maltman, D., Przyborski, S., & Cameron, N. (2013). Galactose-Functionalized PolyHIPE Scaffolds for Use in Routine Three Dimensional Culture of Mammalian Hepatocytes. Biomacromolecules, 14(12), 4271-4277. https://doi.org/10.1021/bm401145x

Three-dimensional (3D) cell culture is regarded as a more physiologically relevant method of growing cells in the laboratory compared to traditional monolayer cultures. Recently, the application of polystyrene-based scaffolds produced using polyHIPE... Read More about Galactose-Functionalized PolyHIPE Scaffolds for Use in Routine Three Dimensional Culture of Mammalian Hepatocytes.

‘Multicopy Multivalent’ Glycopolymer-Stabilized Gold Nanoparticles as Potential Synthetic Cancer Vaccines (2013)
Journal Article
Parry, A., Clemson, N., Ellis, J., Bernhard, S., Davis, B., & Cameron, N. (2013). ‘Multicopy Multivalent’ Glycopolymer-Stabilized Gold Nanoparticles as Potential Synthetic Cancer Vaccines. Journal of the American Chemical Society, 135(25), 9362-9365. https://doi.org/10.1021/ja4046857

Mucin-related carbohydrates are overexpressed on the surface of cancer cells, providing a disease-specific target for cancer immunotherapy. Here, we describe the design and construction of peptide-free multivalent glycosylated nanoscale constructs as... Read More about ‘Multicopy Multivalent’ Glycopolymer-Stabilized Gold Nanoparticles as Potential Synthetic Cancer Vaccines.

Degradable emulsion-templated scaffolds for tissue engineering from thiol– ene photopolymerisation (2012)
Journal Article
Caldwell, S., Johnson, D., Didsbury, M., Murray, B., Wu, J., Przyborski, S., & Cameron, N. (2012). Degradable emulsion-templated scaffolds for tissue engineering from thiol– ene photopolymerisation. Soft Matter, 8(40), 10344-10351. https://doi.org/10.1039/c2sm26250a

Emulsion templating has been used to prepare highly porous polyHIPE materials by thiol–ene photoinitiated network formation. Commercially available multifunctional thiols and acrylates were formulated into water-in-oil high internal phase emulsions (... Read More about Degradable emulsion-templated scaffolds for tissue engineering from thiol– ene photopolymerisation.

Tailoring the morphology of emulsion-templated porous polymers (2006)
Journal Article
Carnachan, R., Bokhari, M., Przyborski, S., & Cameron, N. (2006). Tailoring the morphology of emulsion-templated porous polymers. Soft Matter, 2(7), 608-616. https://doi.org/10.1039/b603211g

Methods with which to tailor the morphology of polystyrene-based emulsion-templated (PolyHIPE) materials are presented. Increasing the temperature of the aqueous phase used to prepare the parent emulsion leads to an increase in average void and inter... Read More about Tailoring the morphology of emulsion-templated porous polymers.

Synthetic and structural studies on C-ethynyl- and C-bromo-carboranes. (2006)
Journal Article
Fox, M., Cameron, A., Low, P., Paterson, M., Batsanov, A., Goeta, A., …Schirlin, J. (2006). Synthetic and structural studies on C-ethynyl- and C-bromo-carboranes. Dalton Transactions, 29, 3544-3560. https://doi.org/10.1039/b517538k

A high-yield preparation of the C-monoethynyl para-carborane, 1-Me3SiC[triple bond, length as m-dash]C-1,12-C2B10H11, from C-monocopper para-carborane and 1-bromo-2-(trimethylsilyl)ethyne, BrC[triple bond, length as m-dash]CSiMe3 is reported. The low... Read More about Synthetic and structural studies on C-ethynyl- and C-bromo-carboranes..

Porous polymers by emulsion templating. (2005)
Journal Article
Barbetta, A., Carnachan, R., Smith, K., Zhao, C., Cameron, N., Kataky, R., …Swan, M. (2005). Porous polymers by emulsion templating. Macromolecular Symposia, 226(1), 203-212. https://doi.org/10.1002/masy.200550819

Highly porous and permeable polymers are produced by polymerisation of the continuous phase of high internal phase emulsions (HIPEs). The morphology and properties of the resulting PolyHIPE materials can be varied, allowing the materials to be optimi... Read More about Porous polymers by emulsion templating..

A carbohydrate-antioxidant hybrid polymer reduces oxidative damage in spermatozoa and enhances fertility (2005)
Journal Article
Fleming, C., Maldjian, A., Da Costa., D., Rullay, A., Haddleton, D., St John, J., …Davis, B. (2005). A carbohydrate-antioxidant hybrid polymer reduces oxidative damage in spermatozoa and enhances fertility. Nature Chemical Biology, 1(5), 270-274. https://doi.org/10.1038/nchembio730

Gamete-gamete interactions are critically modulated by carbohydrate-protein interactions that rely on the carbohydrate-selective recognition of polyvalent carbohydrate structures(1,2). A galactose-binding protein has been identified in mammalian sper... Read More about A carbohydrate-antioxidant hybrid polymer reduces oxidative damage in spermatozoa and enhances fertility.

Morphology and surface area of emulsion-derived (PolyHIPE) solid foams prepared with oil-phase soluble porogenic solvents: Three-component surfactant system (2004)
Journal Article
Barbetta, A., & Cameron, N. (2004). Morphology and surface area of emulsion-derived (PolyHIPE) solid foams prepared with oil-phase soluble porogenic solvents: Three-component surfactant system. Macromolecules, 37(9), 3202-3213. https://doi.org/10.1021/ma035944y

The influence of organic-soluble porogenic solvents (toluene, chlorobenzene, (2-chloroethyl)benzene, 1,2-dichlorobenzene, and 1-chloro-3-phenylpropane) on the morphology and microstructure of poly(divinylbenzene) emulsion-derived (PolyHIPE) solid foa... Read More about Morphology and surface area of emulsion-derived (PolyHIPE) solid foams prepared with oil-phase soluble porogenic solvents: Three-component surfactant system.

Enhanced neurite outgrowth by human neurons grown on solid three-dimensional scaffolds. (2004)
Journal Article
Hayman, M., Smith, K., Cameron, N., & Przyborski, S. (2004). Enhanced neurite outgrowth by human neurons grown on solid three-dimensional scaffolds. Biochemical and Biophysical Research Communications, 314(2), 483-488. https://doi.org/10.1016/j.bbrc.2003.12.135

Growing and differentiating human stem cells in vitro can provide access to study the molecular mechanisms that control cellular development in a manner pertinent to human embryogenesis. To fully understand such processes, however, it is important to... Read More about Enhanced neurite outgrowth by human neurons grown on solid three-dimensional scaffolds..

n-butyl acrylate polymerization mediated by a PROXYL nitroxide (2002)
Journal Article
Cameron, N., & Reid, A. (2002). n-butyl acrylate polymerization mediated by a PROXYL nitroxide. Macromolecules, 35(27), 9890-9895. https://doi.org/10.1021/ma0256892

n-Butyl acrylate has been polymerized in the presence of an alkoxyamine initiator derived from the PROXYL nitroxide 2,2',5-trimethyl-5'-phenylpyrrolidinyl-1-oxyl. It was found that polymerizations were rapid, reaching almost complete conversion withi... Read More about n-butyl acrylate polymerization mediated by a PROXYL nitroxide.

Tissue engineering matrixes by emulsion templating (2002)
Journal Article
Busby, W., Cameron, N., & Jahoda, C. (2002). Tissue engineering matrixes by emulsion templating. Polymer International, 51(10), 871-881. https://doi.org/10.1002/pi.934

Foams containing poly(lactic acid) (PLA) have been prepared from the corresponding macromonomers using high internal phase emulsions (HIPEs) as templates to create the porous structure. The resulting PolyHIPE foams have been investigated by scanning... Read More about Tissue engineering matrixes by emulsion templating.