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‘Multicopy Multivalent’ Glycopolymer-Stabilized Gold Nanoparticles as Potential Synthetic Cancer Vaccines

Parry, AL; Clemson, NA; Ellis, J; Bernhard, SSR; Davis, BG; Cameron, NR.

‘Multicopy Multivalent’ Glycopolymer-Stabilized Gold Nanoparticles as Potential Synthetic Cancer Vaccines Thumbnail


Authors

AL Parry

NA Clemson

J Ellis

SSR Bernhard

BG Davis

NR. Cameron



Abstract

Mucin-related carbohydrates are overexpressed on the surface of cancer cells, providing a disease-specific target for cancer immunotherapy. Here, we describe the design and construction of peptide-free multivalent glycosylated nanoscale constructs as potential synthetic cancer vaccines that generate significant titers of antibodies selective for aberrant mucin glycans. A polymerizable version of the Tn-antigen glycan was prepared and converted into well-defined glycopolymers by Reversible Addition–Fragmentation chain Transfer (RAFT) polymerization. The polymers were then conjugated to gold nanoparticles, yielding ‘multicopy-multivalent’ nanoscale glycoconjugates. Immunological studies indicated that these nanomaterials generated strong and long-lasting production of antibodies that are selective to the Tn-antigen glycan and cross-reactive toward mucin proteins displaying Tn. The results demonstrate proof-of-concept of a simple and modular approach toward synthetic anticancer vaccines based on multivalent glycosylated nanomaterials without the need for a typical vaccine protein component.

Citation

Parry, A., Clemson, N., Ellis, J., Bernhard, S., Davis, B., & Cameron, N. (2013). ‘Multicopy Multivalent’ Glycopolymer-Stabilized Gold Nanoparticles as Potential Synthetic Cancer Vaccines. Journal of the American Chemical Society, 135(25), 9362-9365. https://doi.org/10.1021/ja4046857

Journal Article Type Article
Publication Date Jun 1, 2013
Deposit Date Sep 15, 2013
Publicly Available Date Mar 19, 2014
Journal Journal of the American Chemical Society
Print ISSN 0002-7863
Electronic ISSN 1520-5126
Publisher American Chemical Society
Peer Reviewed Peer Reviewed
Volume 135
Issue 25
Pages 9362-9365
DOI https://doi.org/10.1021/ja4046857
Public URL https://durham-repository.worktribe.com/output/1469826

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Publisher Licence URL
http://creativecommons.org/licenses/by/4.0/

Copyright Statement
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.





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