All Outputs (7)

Synthesis and Evaluation of Europium Complexes that Switch On Luminescence in Lysosomes of Living Cells (2020)
Journal Article
Starck, M., Fradgley, J. D., Pal, R., Zwier, J. M., Lamarque, L., & Parker, D. (2021). Synthesis and Evaluation of Europium Complexes that Switch On Luminescence in Lysosomes of Living Cells. Chemistry - A European Journal, 27(2), 766-777. https://doi.org/10.1002/chem.202003992

A set of four luminescent Eu(III) complexes bearing an extended aryl‐alkynylpyridine chromophore has been studied, showing very different pH‐dependent behaviour in their absorption and emission spectral response. For two complexes with p K a values o... Read More about Synthesis and Evaluation of Europium Complexes that Switch On Luminescence in Lysosomes of Living Cells.

Circularly polarized lanthanide luminescence for advanced security inks (2020)
Journal Article
MacKenzie, L. E., & Pal, R. (2021). Circularly polarized lanthanide luminescence for advanced security inks. Nature Reviews Chemistry, 5, 109-124. https://doi.org/10.1038/s41570-020-00235-4

Authenticating products and documents with security inks is vital to global commerce, security and health. Lanthanide complexes are widely used in luminescent security inks due to their unique and robust photophysical properties. Lanthanide complexes... Read More about Circularly polarized lanthanide luminescence for advanced security inks.

Three-dimensional data capture and analysis of intact eye lenses evidences emmetropia-associated changes and strain-dependent differences in epithelial cell organization (2020)
Journal Article
Kalligeraki, A. A., Isted, A., Pal, R., Saunter, C., Girkin, J., Jarrin, M., Uwineza, A., Obara, B., & Quinlan, R. A. (2020). Three-dimensional data capture and analysis of intact eye lenses evidences emmetropia-associated changes and strain-dependent differences in epithelial cell organization. Scientific Reports, 10, Article 16898. https://doi.org/10.1038/s41598-020-73625-9

Organ and tissue development are highly coordinated processes; lens growth and functional integration into the eye (emmetropia) is a robust example. An epithelial monolayer covers the anterior hemisphere of the lens, and its organization is the key t... Read More about Three-dimensional data capture and analysis of intact eye lenses evidences emmetropia-associated changes and strain-dependent differences in epithelial cell organization.

Anticancer Ruthenium Complexes with HDAC Isoform Selectivity (2020)
Journal Article
Cross, J., Blower, T., Kingdon, A., Pal, R., Picton, D., & Walton, J. (2020). Anticancer Ruthenium Complexes with HDAC Isoform Selectivity. Molecules, 25(10), Article 2383. https://doi.org/10.3390/molecules25102383

The histone deacetylase (HDAC) enzymes have emerged as an important class of molecular targets in cancer therapy, with five inhibitors in clinical use. Recently, it has been shown that a lack of selectivity between the 11 Zn-dependent HDAC isoforms m... Read More about Anticancer Ruthenium Complexes with HDAC Isoform Selectivity.

Development of tris-cyclometalated iridium complexes for cellular imaging through structural modification (2020)
Journal Article
Meksawangwong, S., Gohil, B., Punyain, W., Pal, R., & Kielar, F. (2020). Development of tris-cyclometalated iridium complexes for cellular imaging through structural modification. Inorganica Chimica Acta, 508, Article 119609. https://doi.org/10.1016/j.ica.2020.119609

Herein we report the synthesis and investigation of two novel tris-cyclometalated iridium complexes derived from [Ir(ppy)3] and bearing an aminoalkyl substituent on one of the 2-phenylpyridine ligands. These complexes differ in the number of the alky... Read More about Development of tris-cyclometalated iridium complexes for cellular imaging through structural modification.

Molecular Nanomachines Can Destroy Tissue or Kill Multicellular Eukaryotes (2020)
Journal Article
Gunasekera, R. S., Galbadage, T., Ayala-Orozco, C., Liu, D., García-López, V., Troutman, B. E., Tour, J. J., Pal, R., Krishnan, S., Cirillo, J. D., & Tour, J. M. (2020). Molecular Nanomachines Can Destroy Tissue or Kill Multicellular Eukaryotes. ACS Applied Materials and Interfaces, 12(12), 13657-13670. https://doi.org/10.1021/acsami.9b22595

Light-activated molecular nanomachines (MNMs) can be used to drill holes into prokaryotic (bacterial) cell walls and the membrane of eukaryotic cells, including mammalian cancer cells, by their fast rotational movement, leading to cell death. We exam... Read More about Molecular Nanomachines Can Destroy Tissue or Kill Multicellular Eukaryotes.

Time-resolved luminescence detection of peroxynitrite using a reactivity-based lanthanide probe (2020)
Journal Article
Breen, C., Pal, R., Elsegood, M. R., Teat, S. J., Iza, F., Wende, K., Buckley, B. R., & Butler, S. J. (2020). Time-resolved luminescence detection of peroxynitrite using a reactivity-based lanthanide probe. Chemical Science, 11(12), 3164-3170. https://doi.org/10.1039/c9sc06053g

Peroxynitrite (ONOO−) is a powerful and short-lived oxidant formed in vivo, which can react with most biomolecules directly. To fully understand the roles of ONOO− in cell biology, improved methods for the selective detection and real-time analysis o... Read More about Time-resolved luminescence detection of peroxynitrite using a reactivity-based lanthanide probe.