All Outputs (8)

Hair Follicle Dermal Cells Support Expansion of Murine and Human Embryonic and Induced Pluripotent Stem Cells and Promote Haematopoiesis in Mouse Cultures (2018)
Journal Article
Liu, J., Higgins, C. A., Whitehouse, J. C., Harris, S. J., Crawford, H., Christiano, A. M., Lako, M., Hole, N., & Jahoda, C. A. (2018). Hair Follicle Dermal Cells Support Expansion of Murine and Human Embryonic and Induced Pluripotent Stem Cells and Promote Haematopoiesis in Mouse Cultures. Stem Cells International, 2018, Article 8631432. https://doi.org/10.1155/2018/8631432

In the hair follicle, the dermal papilla (DP) and dermal sheath (DS) support and maintain proliferation and differentiation of the epithelial stem cells that produce the hair fibre. In view of their regulatory properties, in this study, we investigat... Read More about Hair Follicle Dermal Cells Support Expansion of Murine and Human Embryonic and Induced Pluripotent Stem Cells and Promote Haematopoiesis in Mouse Cultures.

Telomerase expression in the mammalian heart (2012)
Journal Article
Richardson, G., Breault, D., Horrocks, G., Cormack, S., Hole, N., & Owens, W. (2012). Telomerase expression in the mammalian heart. FASEB Journal, 26(12), 4832-4840. https://doi.org/10.1096/fj.12-208843

While the mammalian heart has low, but functionally significant, levels of telomerase expression, the cellular population responsible remains incompletely characterized. This study aimed to identify the cell types responsible for cardiac telomerase a... Read More about Telomerase expression in the mammalian heart.

Dermal stem cells can differentiate down an endothelial lineage. (2012)
Journal Article
Bell, E., Richardson, G., Jahoda, C., Phillips, H., Henderson, D., Owens, W., & Hole, N. (2012). Dermal stem cells can differentiate down an endothelial lineage. Stem Cells and Development, 21(16), 3019-3030. https://doi.org/10.1089/scd.2011.0694

Generation of mTert-GFP mice as a model to identify and study tissue progenitor cells. (2008)
Journal Article
Breault, D., Min, I., Carlone, D., Farilla, L., Ambruzs, D., Henderson, D., …Hole, N. (2008). Generation of mTert-GFP mice as a model to identify and study tissue progenitor cells. Proceedings of the National Academy of Sciences, 105(30), 10420-10425. https://doi.org/10.1073/pnas.0804800105

Silencing of the expression of pluripotent driven-reporter genes stably transfected into human pluripotent cells (2008)
Journal Article
Stewart, R., Yang, C., Anyfantis, G., Przyborski, S., Hole, N., Strachan, T., …Lako, M. (2008). Silencing of the expression of pluripotent driven-reporter genes stably transfected into human pluripotent cells. Regenerative Medicine, 3(4), 505-522. https://doi.org/10.2217/17460751.3.4.505

A role for nucleoprotein Zap3 in the reduction of telomerase activity during embryonic stem cell differentiation (2004)
Journal Article
Armstrong, L., Lako, M., van Herpe, I., Evans, J., Saretzki, G., & Hole, N. (2004). A role for nucleoprotein Zap3 in the reduction of telomerase activity during embryonic stem cell differentiation. Mechanisms of development, 121(12), 1509-1522. https://doi.org/10.1016/j.mod.2004.07.005

Telomerase, the enzyme which maintains the ends of linear chromosomes in eukaryotic cells is found in murine embryonic stem cells; however, its activity is downregulated during in vitro differentiation. Previous work has indicated that this is due to... Read More about A role for nucleoprotein Zap3 in the reduction of telomerase activity during embryonic stem cell differentiation.

Hair follicle dermal cells differentiate into adipogenic and osteogenic lineages (2003)
Journal Article
Jahoda, C., Whitehouse, C., Reynolds, A., & Hole, N. (2003). Hair follicle dermal cells differentiate into adipogenic and osteogenic lineages. Experimental Dermatology, 12(6), 849-859. https://doi.org/10.1111/j.0906-6705.2003.00161.x

The adult hair follicle dermal papilla (DP) and dermal sheath (DS) cells are developmentally active cell populations with a proven role in adult hair follicle-cycling activity and unique inductive powers. In stem cell biology, the hair follicle epith... Read More about Hair follicle dermal cells differentiate into adipogenic and osteogenic lineages.

Characterisation of Wnt gene expression during the differentiation of murine embryonic stem cells in vitro: role of Wnt3 in enhancing hematopoietic differentiation (2001)
Journal Article
Lako, M., Lindsay, S., Lincoln, J., Cairns, P., Armstrong, L., & Hole, N. (2001). Characterisation of Wnt gene expression during the differentiation of murine embryonic stem cells in vitro: role of Wnt3 in enhancing hematopoietic differentiation. Mechanisms of development, 103(1-2), 49-59. https://doi.org/10.1016/s0925-4773%2801%2900331-8

The first haematopoietic stem cells in mammalian and non-mammalian vertebrates are derived from mesoderm, therefore genes that are important in mesoderm patterning and formation might also play an essential role in haematopoietic stem cell commitment... Read More about Characterisation of Wnt gene expression during the differentiation of murine embryonic stem cells in vitro: role of Wnt3 in enhancing hematopoietic differentiation.