A role for nucleoprotein Zap3 in the reduction of telomerase activity during embryonic stem cell differentiation
(2004)
Journal Article
Armstrong, L., Lako, M., van Herpe, I., Evans, J., Saretzki, G., & Hole, N. (2004). A role for nucleoprotein Zap3 in the reduction of telomerase activity during embryonic stem cell differentiation. Mechanisms of development, 121(12), 1509-1522. https://doi.org/10.1016/j.mod.2004.07.005
Telomerase, the enzyme which maintains the ends of linear chromosomes in eukaryotic cells is found in murine embryonic stem cells; however, its activity is downregulated during in vitro differentiation. Previous work has indicated that this is due to... Read More about A role for nucleoprotein Zap3 in the reduction of telomerase activity during embryonic stem cell differentiation.