All Outputs (9)

Testing a chemical series inspired by plant stress oxylipin signalling agents for herbicide safening activity (2018)
Journal Article
Brazier-Hicks, M., Knight, K. M., Sellars, J. D., Steel, P. G., & Edwards, R. (2018). Testing a chemical series inspired by plant stress oxylipin signalling agents for herbicide safening activity. Pest Management Science, 74(4), 828-836. https://doi.org/10.1002/ps.4859

BACKGROUND Herbicide safening in cereals is linked to a rapid xenobiotic response (XR), involving the induction of glutathione transferases (GSTs). The XR is also invoked by oxidized fatty acids (oxylipins) released during plant stress, suggesting a... Read More about Testing a chemical series inspired by plant stress oxylipin signalling agents for herbicide safening activity.

Rational Development of Novel Activity Probes for the Analysis of Human Cytochromes P450 (2016)
Journal Article
Sellars, J. D., Skipsey, M., Shaheed, S., Gravell, S., Abumansour, H., Kashtl, G., …Sutton, C. W. (2016). Rational Development of Novel Activity Probes for the Analysis of Human Cytochromes P450. ChemMedChem, 11(11), 1122-1128. https://doi.org/10.1002/cmdc.201600134

The identification and quantification of functional cytochromes P450 (CYPs) in biological samples is proving important for robust analyses of drug efficacy and metabolic disposition. In this study, a novel CYP activity-based probe was rationally desi... Read More about Rational Development of Novel Activity Probes for the Analysis of Human Cytochromes P450.

The First Intramolecular Silene Diels-Alder Reactions (2014)
Journal Article
Czyzewski, M., Sellars, J., Guliashvili, T., Tibbelin, J., Johnstone, L., Bower, J., …Steel, P. (2014). The First Intramolecular Silene Diels-Alder Reactions. Chemical Communications, 50(22), 2919 - 2921. https://doi.org/10.1039/c3cc49526d

The synthesis of silaheterocycles through the first examples of an intramolecular silene Diels–Alder reaction is described.

Key role for a glutathione transferase in multiple-herbicide resistance in grass weeds. (2013)
Journal Article
Cummins, I., Wortley, D., Sabbadin, F., He, Z., Coxon, C., Straker, H., …Edwards, R. (2013). Key role for a glutathione transferase in multiple-herbicide resistance in grass weeds. Proceedings of the National Academy of Sciences, 110(15), 5812-5817. https://doi.org/10.1073/pnas.1221179110

Preparation and complete 1 H and 13C assignment of some pentacyclo [5.4.0.02,6.03,10.05,9]undecane-8,11-dione (PCUD) derivatives (2012)
Journal Article
Kenwright, A. M., & Sellars, J. D. (2012). Preparation and complete 1 H and 13C assignment of some pentacyclo [5.4.0.02,6.03,10.05,9]undecane-8,11-dione (PCUD) derivatives. Magnetic Resonance in Chemistry, 50(12), 803-808. https://doi.org/10.1002/mrc.3879

The preparation of a number of alkyl and alkoxy derivatives of pentacyclo[5.4.0.02,6.03,10.05,9]undecane-8,11-dione derivatives utilising a cheap, practical, low energy, ‘green’, single-pass continuous flow photochemical reactor is reported. Their 1 ... Read More about Preparation and complete 1 H and 13C assignment of some pentacyclo [5.4.0.02,6.03,10.05,9]undecane-8,11-dione (PCUD) derivatives.

The Arabidopsis phi class glutathione transferase AtGSTF2: binding and regulation by biologically active heterocyclic ligands (2011)
Journal Article
Dixon, D., Sellars, J., & Edwards, R. (2011). The Arabidopsis phi class glutathione transferase AtGSTF2: binding and regulation by biologically active heterocyclic ligands. Biochemical Journal, 438(1), 63-70. https://doi.org/10.1042/bj20101884

The plant-specific phi class of glutathione transferases (GSTFs) are often highly stress-inducible and expressed in a tissue-specific manner, suggestive of them having important protective roles. To date, these functions remain largely unknown, altho... Read More about The Arabidopsis phi class glutathione transferase AtGSTF2: binding and regulation by biologically active heterocyclic ligands.

Hosomi-Sakurai Reactions of Silacyclohexenes (2007)
Journal Article
Hughes, N., Pullin, R., Sanganee, M., Sellars, J., Steel, P., & Turner, M. (2007). Hosomi-Sakurai Reactions of Silacyclohexenes. Organic and Biomolecular Chemistry, 5(17), 2841-2848. https://doi.org/10.1039/b709318g

Silacyclic allyl silanes, derived from silene–diene Diels–Alder reactions, combine with acetals in the presence of Lewis acids to afford, following oxidation of the intermediate fluorosilane, either butane-1,4-diols or tetrahydronaphthalenes containi... Read More about Hosomi-Sakurai Reactions of Silacyclohexenes.

Silenes in organic synthesis: a short synthesis of prelactone B (2006)
Journal Article
Sellars, J., & Steel, P. (2006). Silenes in organic synthesis: a short synthesis of prelactone B. Organic and Biomolecular Chemistry, 4(17), 3223-3224. https://doi.org/10.1039/b608989e

Hosomi-Sakurai reactions of silacyclic allyl silanes (2006)
Journal Article
Sellars, J., Steel, P., & Turner, M. (2006). Hosomi-Sakurai reactions of silacyclic allyl silanes. Chemical Communications, 2006(22), 2385-2387. https://doi.org/10.1039/b602642g

Substituted silacyclohexenes, generated through silene–diene [4 + 2] cycloaddition reactions, undergo Lewis acid promoted Sakurai type reactions with acetals to afford, following oxidation of the resultant fluorosilane, 1,4-diols with four contiguous... Read More about Hosomi-Sakurai reactions of silacyclic allyl silanes.