All Outputs (78)

3D adaptive optics in a light sheet microscope (2012)
Journal Article

We report on a single plane illumination microscope (SPIM) incorporating adaptive optics in the imaging arm. We show how aberrations can occur from the sample mounting tube and quantify the aberrations both experimentally and computationally. A wavef... Read More about 3D adaptive optics in a light sheet microscope.

Micro-endoscope for in vivo widefield high spatial resolution fluorescent imaging. (2012)
Journal Article

In this paper we report the design, testing and use of a scannerless probe specifically for minimally invasive imaging of deep tissue in vivo with an epi-fluorescence modality. The probe images a 500 μm diameter field of view through a 710 μm outer d... Read More about Micro-endoscope for in vivo widefield high spatial resolution fluorescent imaging..

Real-time optical gating for three-dimensional beating heart imaging. (2011)
Journal Article

Impact of wavefront distortion and scattering on 2-photon microscopy in mammalian brain tissue. (2011)
Journal Article

Two-photon (2P) microscopy is widely used in neuroscience, but the optical properties of brain tissue are poorly understood. We have investigated the effect of brain tissue on the 2P point spread function (PSF2P) by imaging fluorescent beads through... Read More about Impact of wavefront distortion and scattering on 2-photon microscopy in mammalian brain tissue..

Improved method for kinetic studies in microreactors using flow manipulation and noninvasive Raman spectrometry. (2011)
Journal Article

A novel method has been devised to derive kinetic information about reactions in microfluidic systems. Advantages have been demonstrated over conventional procedures for a Knoevenagel condensation reaction in terms of the time required to obtain the... Read More about Improved method for kinetic studies in microreactors using flow manipulation and noninvasive Raman spectrometry..

Multidepth, multiparticle tracking for active microrheology using a smart camera (2011)
Journal Article

The quantitative measurement of particle motion in optical tweezers is an important tool in the study of microrheology and can be used in a variety of scientific and industrial applications. Active microheology, in which the response of optically tra... Read More about Multidepth, multiparticle tracking for active microrheology using a smart camera.

Non-invasive analysis in micro-reactors using Raman spectrometry with a specially designed probe. (2010)
Journal Article

Two-photon fluorescence excitation microscopy to assess transscleral diffusional pathways in an isolated perfused bovine eye model. (2010)
Journal Article

Development of a low-cost confocal instrument to measure the axial dimensions of components in the anterior section of the eye (2010)
Journal Article

A miniaturised integrated biophotonic point-of care genotyping system. (2010)
Journal Article

Searched-based active optic systems for aberration correction in time-independent applications. (2010)
Journal Article

A demonstration of the effectiveness of a single aberration correction per optical slice in beam scanned optically sectioning microscopes. (2010)
Journal Article

A complete miniaturised genotyping system for the detection of single nucleotide polymorphisms in human DNA samples. (2009)
Journal Article

External Linearization of a MEMS Electrothermal Scanner with Application in a Confocal Microscope. (2009)
Journal Article

A CMOS time-resolved fluorescence lifetime analysis micro-system (2009)
Journal Article

We describe a CMOS-based micro-system for time-resolved fluorescence lifetime analysis. It comprises a 16 × 4 array of single-photon avalanche diodes (SPADs) fabricated in 0.35 μm high-voltage CMOS technology with in-pixel time-gated photon counting... Read More about A CMOS time-resolved fluorescence lifetime analysis micro-system.

Adaptive optics for deeper imaging of biological samples. (2009)
Journal Article

Optical microscopy has been a cornerstone of life science investigations since its first practical application around 400 years ago with the goal being subcellular resolution, three-dimensional images, at depth, in living samples. Nonlinear microscop... Read More about Adaptive optics for deeper imaging of biological samples..

Simultaneous imaging of subplasma membrane & bulk cytoplasmic average Ca2+ concentrations in single smooth muscle cells (2008)
Journal Article

CMOS driven micro-pixel LEDs integrated with single photon avalanche diodes for time resolved fluorescence measurements (2008)
Journal Article

Investigation of dental samples using a 35 MHz focussed ultrasound piezocomposite transducer (2008)
Journal Article

Simultaneous imaging of subplasma membrane and bulk cytoplasmic average Ca2+ concentrations in single smooth muscle cells (2008)
Journal Article