All Outputs (10)

A Consensus Approach to Investigate Undergraduate Pharmacy Students’ Experience of Interprofessional Education (2017)
Journal Article
Nazar, H., Obara, I., Paterson, A., Nazar, Z., Portlock, J., & Husband, A. (2017). A Consensus Approach to Investigate Undergraduate Pharmacy Students’ Experience of Interprofessional Education. American journal of pharmaceutical education, 81(2), 26. https://doi.org/10.5688/ajpe81226

Objective. To assess the development of knowledge, attitudes, and behaviors for collaborative practice among first-year pharmacy students following completion of interprofessional education. Methods. A mixed-methods strategy was employed to detect st... Read More about A Consensus Approach to Investigate Undergraduate Pharmacy Students’ Experience of Interprofessional Education.

Histamine in diabetes: is it time to reconsider? (2016)
Journal Article
Pini, A., Obara, I., Battell, E., Chazot, P. L., & Rosa, A. C. (2016). Histamine in diabetes: is it time to reconsider?. Pharmacological Research, 111, 316-324. https://doi.org/10.1016/j.phrs.2016.06.021

The first studies of histamine and diabetes date back to the 1950s. Since that time the involvement of histamine in diabetes was related to its well known vasoactive properties and permeability leakage effects. In particular, the first evidence for a... Read More about Histamine in diabetes: is it time to reconsider?.

Nonparalytic botulinum molecules for the control of pain (2016)
Journal Article
Mangione, A. S., Obara, I., Maiarú, M., Geranton, S. M., Tassorelli, C., Ferrari, E., Leese, C., Davletov, B., & Hunt, S. P. (2016). Nonparalytic botulinum molecules for the control of pain. PAIN, 157(5), 1045-1055. https://doi.org/10.1097/j.pain.0000000000000478

Local injections of botulinum toxins have been reported to be useful not only for the treatment of peripheral neuropathic pain and migraine but also to cause long-lasting muscle paralysis, a potentially serious side effect. Recently, a botulinum A-ba... Read More about Nonparalytic botulinum molecules for the control of pain.

Inhibition of the Mammalian Target of Rapamycin Complex 1 (mTORC1) signaling pathway reduces itch behaviour in mice (2015)
Journal Article
Obara, I., Medrano, M. C., Signoret-Genest, J., Jiménez-Díaz, L., Géranton, S. M., & Hunt, S. P. (2015). Inhibition of the Mammalian Target of Rapamycin Complex 1 (mTORC1) signaling pathway reduces itch behaviour in mice. PAIN, 156(8), 1519-1529. https://doi.org/10.1097/j.pain.0000000000000197

Activated mammalian target of rapamycin (P-mTOR) has been shown to maintain the sensitivity of subsets of small-diameter primary afferent A-nociceptors. Local or systemic inhibition of the mTOR complex 1 (mTORC1) pathway reduced punctate mechanical a... Read More about Inhibition of the Mammalian Target of Rapamycin Complex 1 (mTORC1) signaling pathway reduces itch behaviour in mice.

Analgesic effects of antidepressants alone and after their local co-administration with morphine in a rat model of neuropathic pain (2014)
Journal Article
Jagla, G., Mika, J., Makuch, W., Obara, I., Wordliczek, J., & Przewlocka, B. (2014). Analgesic effects of antidepressants alone and after their local co-administration with morphine in a rat model of neuropathic pain. Pharmacological Reports, 66(3), 459-465. https://doi.org/10.1016/j.pharep.2013.11.004

Background The therapy of neuropathic pain may include the use of co-analgesics, such as antidepressants, however, their desired analgesic effect is associated with significant side effects. An alternative approach to this is their local administrati... Read More about Analgesic effects of antidepressants alone and after their local co-administration with morphine in a rat model of neuropathic pain.

Axonal protein synthesis and the regulation of primary afferent function (2014)
Journal Article
Obara, I., & Hunt, S. P. (2014). Axonal protein synthesis and the regulation of primary afferent function. Developmental Neurobiology, 74(3), 269-278. https://doi.org/10.1002/dneu.22133

Local protein synthesis has been demonstrated in the peripheral processes of sensory primary afferents and is thought to contribute to the maintenance of the neuron, to neuronal plasticity following injury and also to regeneration of the axon after d... Read More about Axonal protein synthesis and the regulation of primary afferent function.

Nerve injury-induced changes in Homer/glutamate receptor signaling contribute to the development and maintenance of neuropathic pain (2013)
Journal Article
Obara, I., Goulding, S. P., Hu, J. H., Klugmann, M., Worley, P. F., & Szumlinski, K. K. (2013). Nerve injury-induced changes in Homer/glutamate receptor signaling contribute to the development and maintenance of neuropathic pain. PAIN, 154(10), 1932-1945. https://doi.org/10.1016/j.pain.2013.03.035

While group 1 metabotropic glutamate receptors (mGluRs) and ionotropic N-methyl-d-aspartate (NMDA) receptors regulate nociception, the precise molecular mechanism(s) contributing to glutamate signaling in chronic pain remain unclear. Here we not only... Read More about Nerve injury-induced changes in Homer/glutamate receptor signaling contribute to the development and maintenance of neuropathic pain.

Synthetic self-assembling clostridial chimera for modulation of sensory functions (2013)
Journal Article
Ferrari, E., Gu, C., Niranjan, D., Restani, L., Rasetti-Escargueil, C., Obara, I., Geranton, S. M., Arsenault, J., Goetze, T. A., Harper, C. B., Nguyen, T. H., Maywood, E., O'Brien, J., Schiavo, G., Wheeler, D. W., Meunier, F. A., Hastings, M., Edwardson, J. M., Sesardic, D., …Davletov, B. (2013). Synthetic self-assembling clostridial chimera for modulation of sensory functions. Bioconjugate Chemistry, 24(10), 1750-1759. https://doi.org/10.1021/bc4003103

Clostridial neurotoxins reversibly block neuronal communication for weeks and months. While these proteolytic neurotoxins hold great promise for clinical applications and the investigation of brain function, their paralytic activity at neuromuscular... Read More about Synthetic self-assembling clostridial chimera for modulation of sensory functions.

Homers at the Interface between Reward and Pain (2013)
Journal Article
Obara, I., Goulding, S. P., Gould, A. T., Lominac, K. D., Hu, J. H., Zhang, P. W., von Jonquieres, G., Dehoff, M., Xiao, B., Seeburg, P. H., Worley, P. F., Klugmann, M., & Szumlinski, K. K. (2013). Homers at the Interface between Reward and Pain. Frontiers in Psychiatry, 4. https://doi.org/10.3389/fpsyt.2013.00039

Pain alters opioid reinforcement, presumably via neuroadaptations within ascending pain pathways interacting with the limbic system. Nerve injury increases expression of glutamate receptors and their associated Homer scaffolding proteins throughout t... Read More about Homers at the Interface between Reward and Pain.

Axonal protein synthesis: a potential target for pain relief? (2012)
Journal Article
Obara, I., Géranton, S. M., & Hunt, S. P. (2012). Axonal protein synthesis: a potential target for pain relief?. Current Opinion in Pharmacology, 12(1), 42-48. https://doi.org/10.1016/j.coph.2011.10.005

Research on the role of axonal protein synthesis in the regulation of nociceptive mechanisms has grown significantly over the past four years. Recent advances include evidence that local translation of mRNA can occur in adult primary afferents under... Read More about Axonal protein synthesis: a potential target for pain relief?.