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Axonal protein synthesis: a potential target for pain relief?

Obara, I.; Géranton, S.M.; Hunt, S.P.

Axonal protein synthesis: a potential target for pain relief? Thumbnail


Authors

I. Obara

S.M. Géranton

S.P. Hunt



Abstract

Research on the role of axonal protein synthesis in the regulation of nociceptive mechanisms has grown significantly over the past four years. Recent advances include evidence that local translation of mRNA can occur in adult primary afferents under the control of the mammalian target of rapamycin (mTOR) and the extracellular signal-regulated kinase (ERK) signaling pathways. Studies investigating the effect of mTOR and ERK pathway inhibitors in a number of pain models suggest that these signaling pathways may act independently, depending on the type of sensory afferents studied. The evidence that nociception can be regulated at the level of mRNA translation in nociceptors has important implications for the understanding of the mechanisms of nociceptive plasticity and therefore for therapeutic interventions in chronic pain conditions.

Citation

Obara, I., Géranton, S., & Hunt, S. (2012). Axonal protein synthesis: a potential target for pain relief?. Current Opinion in Pharmacology, 12(1), 42-48. https://doi.org/10.1016/j.coph.2011.10.005

Journal Article Type Article
Publication Date Feb 1, 2012
Deposit Date Mar 4, 2013
Publicly Available Date Jun 14, 2016
Journal Current Opinion in Pharmacology
Print ISSN 1471-4892
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 12
Issue 1
Pages 42-48
DOI https://doi.org/10.1016/j.coph.2011.10.005
Public URL https://durham-repository.worktribe.com/output/1466157

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