All Outputs (73)

The Aarhus statement on cancer diagnostic research: turning recommendations into new survey instruments (2018)
Journal Article
Coxon, D., Campbell, C., Walter, F. M., Scott, S. E., Neal, R. D., Vedsted, P., Emery, J., Rubin, G., Hamilton, W., & Weller, D. (2018). The Aarhus statement on cancer diagnostic research: turning recommendations into new survey instruments. BMC Health Services Research, 18(1), Article 677. https://doi.org/10.1186/s12913-018-3476-0

Background Over recent years there has been a growth in cancer early diagnosis (ED) research, which requires valid measurement of routes to diagnosis and diagnostic intervals. The Aarhus Statement, published in 2012, provided methodological guidance... Read More about The Aarhus statement on cancer diagnostic research: turning recommendations into new survey instruments.

The researchers’ role in knowledge translation: a realist evaluation of the development and implementation of diagnostic pathways for cancer in two United Kingdom localities (2017)
Journal Article
Banks, J., Wye, L., Hall, N., Rooney, J., Walter, F. M., Hamilton, W., …Rubin, G. (2017). The researchers’ role in knowledge translation: a realist evaluation of the development and implementation of diagnostic pathways for cancer in two United Kingdom localities. Health Research Policy and Systems, 15(1), Article 103. https://doi.org/10.1186/s12961-017-0267-8

Background: In examining an initiative to develop and implement new cancer diagnostic pathways in two English localities, this paper evaluates ‘what works’ and examines the role of researchers in facilitating knowledge translation amongst teams of lo... Read More about The researchers’ role in knowledge translation: a realist evaluation of the development and implementation of diagnostic pathways for cancer in two United Kingdom localities.

Understanding symptom appraisal and help-seeking in people with symptoms suggestive of pancreatic cancer: a qualitative study (2017)
Journal Article
Mills, K., Birt, L., Emery, J. D., Hall, N., Banks, J., Johnson, M., …Walter, F. M. (2017). Understanding symptom appraisal and help-seeking in people with symptoms suggestive of pancreatic cancer: a qualitative study. BMJ Open, 7(9), Article e015682. https://doi.org/10.1136/bmjopen-2016-015682

Objective: Pancreatic cancer has poor survival rates due to non-specific symptoms leading to later diagnosis. Understanding how patients interpret their symptoms could inform approaches to earlier diagnosis. This study sought to explore symptom appra... Read More about Understanding symptom appraisal and help-seeking in people with symptoms suggestive of pancreatic cancer: a qualitative study.

Evidence of advanced stage colorectal cancer with longer diagnostic intervals: a pooled analysis of seven primary care cohorts comprising 11720 patients in five countries (2017)
Journal Article
Tørring, M., Murchie, P., Hamilton, W., Vedsted, P., Esteva, M., Lautrup, M., …Rubin, G. (2017). Evidence of advanced stage colorectal cancer with longer diagnostic intervals: a pooled analysis of seven primary care cohorts comprising 11720 patients in five countries. British Journal of Cancer, 117(6), 888-897. https://doi.org/10.1038/bjc.2017.236

Background: The benefits from expedited diagnosis of symptomatic cancer are uncertain. We aimed to analyse the relationship between stage of colorectal cancer (CRC) and the primary and specialist care components of the diagnostic interval. Methods: W... Read More about Evidence of advanced stage colorectal cancer with longer diagnostic intervals: a pooled analysis of seven primary care cohorts comprising 11720 patients in five countries.

Typical and atypical presenting symptoms of breast cancer and their associations with diagnostic intervals: Evidence from a national audit of cancer diagnosis (2017)
Journal Article
Koo, M. M., von Wagner, C., Abel, G. A., McPhail, S., Rubin, G. P., & Lyratzopoulos, G. (2017). Typical and atypical presenting symptoms of breast cancer and their associations with diagnostic intervals: Evidence from a national audit of cancer diagnosis. Cancer Epidemiology, 48, 140-146. https://doi.org/10.1016/j.canep.2017.04.010

Introduction Most symptomatic women with breast cancer have relatively short diagnostic intervals but a substantial minority experience prolonged journeys to diagnosis. Atypical presentations (with symptoms other than breast lump) may be responsible.... Read More about Typical and atypical presenting symptoms of breast cancer and their associations with diagnostic intervals: Evidence from a national audit of cancer diagnosis.

Clinical features of bowel disease in patients aged <50 years in primary care: a large case-control study (2017)
Journal Article
Stapley, S. A., Rubin, G. P., Alsina, D., Shephard, E. A., Rutter, M. D., & Hamilton, W. T. (2017). Clinical features of bowel disease in patients aged

Background Incidences of colorectal cancer (CRC) and inflammatory bowel disease (IBD) are increasing in those aged <50 years. Aim To identify and quantify clinical features in primary care of CRC/IBD in those aged <50 years. This study considered the...

Socio-economic inequalities in stage at diagnosis, and in time intervals on the lung cancer pathway from first symptom to treatment: systematic review and meta-analysis (2016)
Journal Article
Forrest, L., Sowden, S., Rubin, G., Whitel, M., & Adams, J. (2016). Socio-economic inequalities in stage at diagnosis, and in time intervals on the lung cancer pathway from first symptom to treatment: systematic review and meta-analysis. Thorax, 72(5), 430-436. https://doi.org/10.1136/thoraxjnl-2016-209013

Cancer diagnosis at an early stage increases the chance of curative treatment and of survival. It has been suggested that delays on the pathway from first symptom to diagnosis and treatment may be socio-economically patterned, and contribute to socio... Read More about Socio-economic inequalities in stage at diagnosis, and in time intervals on the lung cancer pathway from first symptom to treatment: systematic review and meta-analysis.

Symptoms and patient factors associated with diagnostic intervals for pancreatic cancer (SYMPTOM pancreatic study): a prospective cohort study (2016)
Journal Article
Walter, F., Mills, K., Mendonca, S., Abel, G., Basu, B., Carroll, N., …Emery, J. (2016). Symptoms and patient factors associated with diagnostic intervals for pancreatic cancer (SYMPTOM pancreatic study): a prospective cohort study. The Lancet Gastroenterology & Hepatology, 1(4), 298-306. https://doi.org/10.1016/s2468-1253%2816%2930079-6

Background Pancreatic cancer is the tenth most common cancer in the UK; however, outcomes are poor, in part due to late diagnosis. We aimed to identify symptoms and other clinical and sociodemographic factors associated with pancreatic cancer diagnos... Read More about Symptoms and patient factors associated with diagnostic intervals for pancreatic cancer (SYMPTOM pancreatic study): a prospective cohort study.

Symptoms and patient factors associated with longer time to diagnosis for colorectal cancer: results from a prospective cohort study (2016)
Journal Article
Walter, F., Emery, J., Mendonca, S., Hall, N., Morris, H., Mills, K., …Rubin, G. (2016). Symptoms and patient factors associated with longer time to diagnosis for colorectal cancer: results from a prospective cohort study. British Journal of Cancer, 115(5), 533-541. https://doi.org/10.1038/bjc.2016.221

background: The objective of this study is to investigate symptoms, clinical factors and socio-demographic factors associated with colorectal cancer (CRC) diagnosis and time to diagnosis. methods: Prospective cohort study of participants referred for... Read More about Symptoms and patient factors associated with longer time to diagnosis for colorectal cancer: results from a prospective cohort study.

Improving early diagnosis of symptomatic cancer (2016)
Journal Article
Hamilton, W., Walter, F., Rubin, G., & Neal, R. (2016). Improving early diagnosis of symptomatic cancer. Nature Reviews Clinical Oncology, 13(12), 740-749. https://doi.org/10.1038/nrclinonc.2016.109

Much time, effort and investment goes into the diagnosis of symptomatic cancer, with the expectation that this approach brings clinical benefits. This investment of resources has been particularly noticeable in the UK, which has, for several years, a... Read More about Improving early diagnosis of symptomatic cancer.

Evaluating a computer aid for assessing stomach symptoms (ECASS): study protocol for a randomised controlled trial (2016)
Journal Article
Moore, H., Nixon, C., Tariq, A., Emery, J., Hamilton, W., Hoare, Z., …Rubin, G. (2016). Evaluating a computer aid for assessing stomach symptoms (ECASS): study protocol for a randomised controlled trial. Trials, 17(1), Article 184. https://doi.org/10.1186/s13063-016-1307-3

Background: For most cancers, only a minority of patients have symptoms meeting the National Institute for Health and Clinical Excellence guidance for urgent referral. For gastro-oesophageal cancers, the ‘alarm’ symptoms of dysphagia and weight loss... Read More about Evaluating a computer aid for assessing stomach symptoms (ECASS): study protocol for a randomised controlled trial.

International variation in adherence to referral guidelines for suspected cancer: a secondary analysis of survey data (2016)
Journal Article
Nicholson, B., Mant, D., Shinkins, B., Rose, P., Neal, R., Hart, N., …Rubin, G. (2016). International variation in adherence to referral guidelines for suspected cancer: a secondary analysis of survey data. British Journal of General Practice, 66(643), e106-e113. https://doi.org/10.3399/bjgp16x683449

Background Variation in cancer survival persists between comparable nations and appears to be due, in part, to primary care practitioners (PCPs) having different thresholds for acting definitively in response to cancer-related symptoms. Aim To explor... Read More about International variation in adherence to referral guidelines for suspected cancer: a secondary analysis of survey data.

For which cancers might patients benefit most from expedited symptomatic diagnosis? Construction of a ranking order by a modified Delphi technique (2015)
Journal Article
Hamilton, W., Stapley, S., Campbell, C., Lyratzopoulos, G., Rubin, G., & Neal, R. (2015). For which cancers might patients benefit most from expedited symptomatic diagnosis? Construction of a ranking order by a modified Delphi technique. BMC Cancer, 15, Article 820. https://doi.org/10.1186/s12885-015-1865-x

Background This study aimed to answer the question ‘for which cancers, in a symptomatic patient, does expediting the diagnosis provide an improvement in mortality and/or morbidity?’ Methods An initial ranking was constructed from previous work identi... Read More about For which cancers might patients benefit most from expedited symptomatic diagnosis? Construction of a ranking order by a modified Delphi technique.

Use of the English urgent referral pathway for suspected cancer and mortality in patients with cancer: cohort study (2015)
Journal Article
Møller, H., Gildea, C., Meechan, D., Rubin, G., Round, T., & Vedsted, P. (2015). Use of the English urgent referral pathway for suspected cancer and mortality in patients with cancer: cohort study. eBMJ (London), 351, Article h5102. https://doi.org/10.1136/bmj.h5102

Objective To assess the overall effect of the English urgent referral pathway on cancer survival. Setting 8049 general practices in England. Design Cohort study. Linked information from the national Cancer Waiting Times database, NHS Exeter database,... Read More about Use of the English urgent referral pathway for suspected cancer and mortality in patients with cancer: cohort study.

Risk of ischaemic heart disease in patients with inflammatory bowel disease: cohort study using the General Practice Research Database (2015)
Journal Article
Close, H., Mason, J., Wilson, D., Hungin, A., Jones, R., & Rubin, G. (2015). Risk of ischaemic heart disease in patients with inflammatory bowel disease: cohort study using the General Practice Research Database. PLoS ONE, 10(10), Article e0139745. https://doi.org/10.1371/journal.pone.0139745

Objective Patients with inflammatory bowel disease (IBD) demonstrate an inflammatory response which bears some similarities to that seen in ischaemic heart disease (IHD). The nature of the association of IBD with IHD is uncertain. We aimed to define... Read More about Risk of ischaemic heart disease in patients with inflammatory bowel disease: cohort study using the General Practice Research Database.

Symptom appraisal and healthcare-seeking for symptoms suggestive of colorectal cancer: a qualitative study (2015)
Journal Article
Hall, N., Birt, L., Banks, J., Emery, J., Mills, K., Johnson, M., …Walter, F. (2015). Symptom appraisal and healthcare-seeking for symptoms suggestive of colorectal cancer: a qualitative study. BMJ Open, 5(10), Article e008448. https://doi.org/10.1136/bmjopen-2015-008448

Objectives Timely diagnosis of colorectal cancer is important to improve survival. This study explored symptom appraisal and help-seeking among patients referred to specialist services with symptoms of colorectal cancer. Design Qualitative in-depth i... Read More about Symptom appraisal and healthcare-seeking for symptoms suggestive of colorectal cancer: a qualitative study.

The expanding role of primary care in cancer control (2015)
Journal Article
Rubin, G., Berendsen, A., Crawford, M., Dommett, R., Earle, C., Emery, J., …Zimmermann, C. (2015). The expanding role of primary care in cancer control. The Lancet Oncology, 16(12), 1231-1272. https://doi.org/10.1016/s1470-2045%2815%2900205-3

The nature of cancer control is changing, with an increasing emphasis, fuelled by public and political demand, on prevention, early diagnosis, and patient experience during and after treatment. At the same time, primary care is increasingly promoted,... Read More about The expanding role of primary care in cancer control.

Systematic review of the use of data from national childhood obesity surveillance programmes in primary care: a conceptual synthesis (2015)
Journal Article
Henderson, E., Ells, L., Rubin, G., & Hunter, D. (2015). Systematic review of the use of data from national childhood obesity surveillance programmes in primary care: a conceptual synthesis. Obesity Reviews, 16(11), 962-971. https://doi.org/10.1111/obr.12319

This study reviewed the use in primary care of national surveillance data for children to determine the data's potential utility to inform policy and practice decisions on how to prevent and treat childhood obesity. We reviewed the 28 countries ident... Read More about Systematic review of the use of data from national childhood obesity surveillance programmes in primary care: a conceptual synthesis.

The Helicobacter Eradication Aspirin Trial (HEAT): A Large Simple Randomised Controlled Trial Using Novel Methodology in Primary Care (2015)
Journal Article
Dumbleton, J., Avery, A., Coupland, C., Hobbs, F., Kendrick, D., Moore, M., …Hawkey, C. (2015). The Helicobacter Eradication Aspirin Trial (HEAT): A Large Simple Randomised Controlled Trial Using Novel Methodology in Primary Care. EBioMedicine, 2(9), 1200-1204. https://doi.org/10.1016/j.ebiom.2015.07.012

Background Clinical trials measuring the effect of an intervention on clinical outcomes are more influential than those investigating surrogate measures but are costly. We developed methods to reduce costs substantially by using existing data in prim... Read More about The Helicobacter Eradication Aspirin Trial (HEAT): A Large Simple Randomised Controlled Trial Using Novel Methodology in Primary Care.

Irritable bowel syndrome: an integrated explanatory model for clinical practice (2015)
Journal Article
Hungin, A., Becher, A., Cayley, B., Heidelbaugh, J., Muris, J., Rubin, G., …De Wit, N. (2015). Irritable bowel syndrome: an integrated explanatory model for clinical practice. Neurogastroenterology and Motility, 27(6), 750-763. https://doi.org/10.1111/nmo.12524

Background Although irritable bowel syndrome (IBS) is a symptom-based diagnosis, clinicians' management of and communication about the disorder is often hampered by an unclear conceptual understanding of the nature of the problem. We aimed to elucida... Read More about Irritable bowel syndrome: an integrated explanatory model for clinical practice.