All Outputs (3)

Current understanding of the interplay between extracellular matrix remodelling and gut permeability in health and disease (2024)
Journal Article
Vilardi, A., Przyborski, S., Mobbs, C., Rufini, A., & Tufarelli, C. (2024). Current understanding of the interplay between extracellular matrix remodelling and gut permeability in health and disease. Cell Death Discovery, 10(1), Article 258. https://doi.org/10.1038/s41420-024-02015-1

The intestinal wall represents an interactive network regulated by the intestinal epithelium, extracellular matrix (ECM) and mesenchymal compartment. Under healthy physiological conditions, the epithelium undergoes constant renewal and forms an integ... Read More about Current understanding of the interplay between extracellular matrix remodelling and gut permeability in health and disease.

An in vitro model to study immune activation, epithelial disruption and stromal remodelling in inflammatory bowel disease and fistulising Crohn’s disease (2024)
Journal Article
Mobbs, C. L., Darling, N. J., & Przyborski, S. (2024). An in vitro model to study immune activation, epithelial disruption and stromal remodelling in inflammatory bowel disease and fistulising Crohn’s disease. Frontiers in Immunology, 15, Article 1357690. https://doi.org/10.3389/fimmu.2024.1357690

At present, preclinical models of inflammatory bowel disease (IBD) are insufficient, limiting translation between research and new therapeutics. This is especially true for fistulising Crohn’s disease (CD), as the severe lack of relevant models hinde... Read More about An in vitro model to study immune activation, epithelial disruption and stromal remodelling in inflammatory bowel disease and fistulising Crohn’s disease.

Bioengineering Novel in vitro Co-culture Models That Represent the Human Intestinal Mucosa With Improved Caco-2 Structure and Barrier Function (2020)
Journal Article
Darling, N. J., Mobbs, C. L., González-Hau, A. L., Freer, M., & Przyborski, S. (2020). Bioengineering Novel in vitro Co-culture Models That Represent the Human Intestinal Mucosa With Improved Caco-2 Structure and Barrier Function. Frontiers in Bioengineering and Biotechnology, 8, Article 992. https://doi.org/10.3389/fbioe.2020.00992

The Caco-2 monolayer is the most widely used in vitro model of the human intestinal mucosa to study absorption. However, models lack communication from other cells present in the native intestine, such as signals from fibroblasts in the lamina propri... Read More about Bioengineering Novel in vitro Co-culture Models That Represent the Human Intestinal Mucosa With Improved Caco-2 Structure and Barrier Function.