All Outputs (4)

Diverse Durham collection phages demonstrate complex BREX defence responses (2023)
Journal Article
Kelly, A., Went, S. C., Mariano, G., Shaw, L. P., Picton, D. M., Duffner, S. J., Coates, I., Herdman-Grant, R., Gordeeva, J., Drobiazko, A., Isaev, A., Lee, Y.-J., Luyten, Y., Morgan, R. D., Weigele, P., Severinov, K., Wenner, N., Hinton, J. C., & Blower, T. R. (2023). Diverse Durham collection phages demonstrate complex BREX defence responses. Applied and Environmental Microbiology, 89(9), Article e00623-23. https://doi.org/10.1128/aem.00623-23

Bacteriophages (phages) outnumber bacteria ten-to-one and cause infections at a rate of 1025 per second. The ability of phages to reduce bacterial populations makes them attractive alternative antibacterials for use in combating the rise in antimicro... Read More about Diverse Durham collection phages demonstrate complex BREX defence responses.

Toxin–antitoxin systems as mediators of phage defence and the implications for abortive infection (2023)
Journal Article
Kelly, A., Arrowsmith, T., Went, S., & Blower, T. (2023). Toxin–antitoxin systems as mediators of phage defence and the implications for abortive infection. Current Opinion in Microbiology, 73, Article 102293. https://doi.org/10.1016/j.mib.2023.102293

Bacteria have evolved a broad range of defence mechanisms to protect against infection by their viral parasites, bacteriophages (phages). Toxin–antitoxin (TA) systems are small loci found throughout bacteria and archaea that in some cases provide pha... Read More about Toxin–antitoxin systems as mediators of phage defence and the implications for abortive infection.

The engulfasome in C. difficile: Variations on protein machineries (2019)
Journal Article
Kelly, A., & Salgado, P. S. (2019). The engulfasome in C. difficile: Variations on protein machineries. Anaerobe, 60, 102091. https://doi.org/10.1016/j.anaerobe.2019.102091

Clostridioides difficile infection (CDI) continues to be a substantial healthcare burden, and the changing disease profile raises new challenges in CDI management, both in clinical settings and in the community. CDI is transmitted by spores, which ar... Read More about The engulfasome in C. difficile: Variations on protein machineries.

Peptidoglycan degradation machinery in Clostridium difficile forespore engulfment (2018)
Journal Article
Dembek, M., Kelly, A., Barwinska‐Sendra, A., Tarrant, E., Stanley, W. A., Vollmer, D., …Salgado, P. S. (2018). Peptidoglycan degradation machinery in Clostridium difficile forespore engulfment. Molecular Microbiology, 110(3), 390-410. https://doi.org/10.1111/mmi.14091

Clostridium difficile remains the leading cause of antibiotic-associated diarrhoea in hospitals worldwide, linked to significant morbidity and mortality. As a strict anaerobe, it produces dormant cell forms - spores - which allow it to survive in the... Read More about Peptidoglycan degradation machinery in Clostridium difficile forespore engulfment.