A role for proprioceptors in sngception

Lee, Cheng-Han; Lin, Jiann-Her; Lin, Shing-Hong; Chang, Chu-Ting; Wu, Yu-Wei; Bewick, Guy; Banks, Robert W; Gründer, Stefan; Hochgeschwender, Ute; Chen, Chih-Cheng

Abstract

Proprioceptors are primary mechanosensory neurons to monitor the status of muscle contraction and/or body position ( ). Although proprioceptors are known as non-nociceptive mechanoreceptors, they also express the pro-nociceptive acid-sensing ion channel 3 (ASIC3) ( - ). To probe the role for proprioceptors in sensing acidosis (or sngception) ( ), we found that genetic deletion of in proprioceptors but not in nociceptors abolished acid-induced chronic hyperalgesia in mice. Chemo-optogenetically activating proprioceptors resulted in hyperalgesic priming that favored chronic pain induced by acidosis. In humans, intramuscular acidification induced acid perception but not pain. Conversely, in a spinal cord-injured patient who lost pain sensation in the right leg, proprioception and sngception were remaining somatosensory functions, associated with the spinal dorsal column. Together, evidence from both mouse and human studies suggests a role for proprioceptors in sngception.

Citation

Lee, C.-H., Lin, J.-H., Lin, S.-H., Chang, C.-T., Wu, Y.-W., Bewick, G., Banks, R. W., Gründer, S., Hochgeschwender, U., & Chen, C.-C. (2025). A role for proprioceptors in sngception. Science Advances, 11(5), Article eabc5219. https://doi.org/10.1126/sciadv.abc5219

• Journal Article Type: Article
• Acceptance Date: Jan 2, 2025
• Online Publication Date: Jan 31, 2025
• Publication Date: Jan 1, 2025
• Deposit Date: Feb 18, 2025
• Publicly Available Date: Feb 18, 2025
• Journal: Science advances
• Electronic ISSN: 2375-2548
• Publisher: American Association for the Advancement of Science
• Peer Reviewed: Peer Reviewed
• Volume: 11
• Issue: 5
• Article Number: eabc5219
• DOI: https://doi.org/10.1126/sciadv.abc5219
• Keywords: Mice, Proprioception, Acid Sensing Ion Channels - metabolism - genetics, Acidosis - metabolism, Nociceptors - metabolism - physiology, Animals, Humans, Male, Female, Mice, Knockout, Hyperalgesia - metabolism - physiopathology
• Public URL: https://durham-repository.worktribe.com/output/3482358