One His, two His…the emerging roles of histidine in cellular nickel trafficking

Chivers, Peter T; Basak, Priyanka; Maroney, Michael J

Abstract

Biological environments present a complex array of metal-binding ligands. Metal-binding proteins have been the overwhelming focus of study because of their important and well-defined biological roles. Consequently, the presence of functional low molecular weight (LMW) metal-ligand complexes has been overlooked in terms of their roles in metallobiochemistry, particularly within cells. Recent studies in microbial systems have illuminated the different roles of L-histidine in nickel uptake, gene expression, and metalloenzyme maturation. In this focused critical review, these roles are surveyed in the context of the coordination chemistry of Ni(II) ions and the amino acid histidine, and the physico-chemical properties of nickel complexes of histidine. These complexes are fundamentally important to cellular metal homeostasis and further work is needed to fully define their contributions. [Abstract copyright: Copyright © 2024 Elsevier Inc. All rights reserved.]

Citation

Chivers, P. T., Basak, P., & Maroney, M. J. (2024). One His, two His…the emerging roles of histidine in cellular nickel trafficking. Journal of Inorganic Biochemistry, 259, Article 112668. https://doi.org/10.1016/j.jinorgbio.2024.112668

• Journal Article Type: Article
• Acceptance Date: Jul 16, 2024
• Online Publication Date: Jul 17, 2024
• Publication Date: 2024-10
• Deposit Date: Aug 22, 2024
• Publicly Available Date: Aug 27, 2024
• Journal: Journal of Inorganic Biochemistry
• Print ISSN: 0162-0134
• Electronic ISSN: 1873-3344
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 259
• Article Number: 112668
• DOI: https://doi.org/10.1016/j.jinorgbio.2024.112668
• Keywords: Nickel - chemistry - metabolism, Histidine - chemistry - metabolism, Nickel-trafficking, Histidine, Speciation, Low molecular weight ligands, Homeostasis, Maturation, Coordination Complexes - chemistry - metabolism
• Public URL: https://durham-repository.worktribe.com/output/2745938