Epidemiology of malaria in Gabon: A systematic review and meta-analysis from 1980 to 2023.

Sima-Biyang, Yann Vital; Ontoua, Steede Seinnat; Longo-Pendy, Neil Michel; Mbou-Boutambe, Clark; Makouloutou-Nzassi, Patrice; Moussadji, Cyr Kinga; Lekana-Douki, Jean-Bernard; Boundenga, Larson

Abstract

The objective of this were conducted to elucidate spatiotemporal variations in malaria epidemiology in Gabon since 1980. For that, five databases, were used to collect and identify all studies published between 1980 and 2023 on malaria prevalence, antimalarial drug resistance, markers of antimalarial drug resistance and insecticide resistance marker. The findings suggest that Gabon continues to face malaria as an urgent public health problem, with persistently high prevalence rates. Markers of resistance to CQ persist despite its withdrawal, and markers of resistance to SP have emerged with a high frequency, reaching 100 %, while ACTs remain effective. Also, recent studies have identified markers of resistance to the insecticides Kdr-w and Kdr-e at frequencies ranging from 25 % to 100 %. Ace1R mutation was reported with a frequency of 0.4 %. In conclusion, the efficacy of ACTs remains above the threshold recommended by the WHO. Organo-phosphates and carbamates could provide an alternative for vector control. [Abstract copyright: Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.]

Citation

Sima-Biyang, Y. V., Ontoua, S. S., Longo-Pendy, N. M., Mbou-Boutambe, C., Makouloutou-Nzassi, P., Moussadji, C. K., …Boundenga, L. (2024). Epidemiology of malaria in Gabon: A systematic review and meta-analysis from 1980 to 2023. Journal of Infection and Public Health, 17(7), Article 102459. https://doi.org/10.1016/j.jiph.2024.05.047

• Journal Article Type: Article
• Acceptance Date: May 22, 2024
• Online Publication Date: Jun 3, 2024
• Publication Date: Jun 3, 2024
• Deposit Date: Jul 3, 2024
• Publicly Available Date: Jul 3, 2024
• Journal: Journal of infection and public health
• Print ISSN: 1876-0341
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 17
• Issue: 7
• Article Number: 102459
• DOI: https://doi.org/10.1016/j.jiph.2024.05.047
• Keywords: Vector resistance, Antimalarials - therapeutic use, Epidemiology, Gabon, Insecticide Resistance, Gabon - epidemiology, Animals, Spatial distribution, Malaria, Malaria - epidemiology, Humans, Prevalence, Drug Resistance, Drug resistance, Insecticides - pharmacology
• Public URL: https://durham-repository.worktribe.com/output/2512802