Language lateralization in temporal lobe epilepsy: A behavioral screening tool for surgical planning.

Elizalde Acevedo, Bautista; Agüero Vera, Valentina; Oddo, Silvia; De Anchorena, Delfina; Mohr, Christine; Kochen, Silvia; Hausmann, Markus; Alba-Ferrara, Lucía

Abstract

Objective: Temporal lobe epilepsy can disturb eloquent areas, affecting language. We applied a visually-mediated task to measure lateralization of language recognition in drug-resistant temporal lobe epilepsy.

Method: Patients with left (n = 26), right (n = 28) temporal lobe epilepsy and controls (n = 30) were administered the translingual lexical decision task. We performed repeated measures analyses of variance, with the visual half-field as an intrasubject factor and the group as an intersubject factor.

Results: A main effect of visual half-field was found, showing the right visual field (left hemisphere) advantage for both accuracy and response time. A main effect of the group was found in accuracy, showing that both epilepsy groups performed less accurately than controls, and left temporal lobe epilepsy performed less accurately than right temporal lobe epilepsy. Also, the group-by-visual half-field interaction was significant. Post hoc t tests indicated the controls and right temporal lobe epilepsy performed better in the right visual field than in the left visual field, whereas no visual half-field effect was found in left temporal lobe epilepsy. For response times, the interaction was also significant. Post hoc t tests showed a significant right visual-field advantage for controls (two-tailed) and for the right temporal lobe epilepsy (one-tailed). Right visual-field advantage was absent in left temporal lobe epilepsy.

Conclusions: The translingual lexical decision task can efficiently distinguish between left and right temporal lobe epilepsy. Compared to right temporal lobe epilepsy and controls, language lateralization is diminished in left temporal lobe epilepsy. The potential use of the translingual lexical decision task as an effective noninvasive presurgical language lateralization screening tool is highlighted.

Citation

Elizalde Acevedo, B., Agüero Vera, V., Oddo, S., De Anchorena, D., Mohr, C., Kochen, S., Hausmann, M., & Alba-Ferrara, L. (2024). Language lateralization in temporal lobe epilepsy: A behavioral screening tool for surgical planning. Neuropsychology, 38(6), 599-608. https://doi.org/10.1037/neu0000962

• Journal Article Type: Article
• Acceptance Date: Apr 9, 2024
• Online Publication Date: May 30, 2024
• Publication Date: May 30, 2024
• Deposit Date: Jun 4, 2024
• Publicly Available Date: Jun 4, 2024
• Journal: Neuropsychology
• Print ISSN: 0894-4105
• Electronic ISSN: 1931-1559
• Publisher: American Psychological Association
• Peer Reviewed: Peer Reviewed
• Volume: 38
• Issue: 6
• Pages: 599-608
• DOI: https://doi.org/10.1037/neu0000962
• Public URL: https://durham-repository.worktribe.com/output/2472633