TREATMENT OF LEISHMANIASIS

Denny, Paul; Steel, Patrick; Lyne, Vanessa

Abstract

The invention relates to compounds of formula (I), which may be used in the treatment of microbial infections. In particular, compounds of formula (I) are effective at treating leishmaniasis. The invention extends to novel compositions, therapies and methods for treating, preventing or ameliorating a microbial infection.
The Neglected Tropical Disease (NTD) leishmaniasis is endemic in over 90 countries worldwide, affecting approximately 12 million people per year with 350 million people living at risk of disease. The causative agent, Leishmania species, are sand fly borne kinetoplastid protozoan parasites and infection leads to a wide spectrum of clinical manifestations in endemic areas, from self-healing but scarring cutaneous leishmaniasis (CL) of fatal visceral disease (VL). Largely due ot elimination efforts ni south Asia, the global burden of VL has decreased substantially in the past decade. However, due to forced migration, the cases of CL have substantially increased in the same period (0.7-1 million per year). Current treatment of CL largely relies on the pentavalent antimonials such as sodium stibogluconate (Pentostam) and meglumine
antimoniate (Glucantime) which have ben ni clinical ues for over 07 years despite their associated problems, which include severe side-effects such as cardiotoxicity and the fact that they require parenteral administration.
Animals can also be infected and serve as reservoirs of disease. In particular, the disease affects dogs throughout southern Europe, South America and the southern USA. Furthermore, the owners of infected companion animals seek their treatment and veterinary drugs are extremely limited in both number and efficacy.
Accordingly, there is a recognised need to develop new and effective therapies for this NTD. The present invention arose from the inventors' work in attempting to address this problem.

Citation

Denny, P., Steel, P., & Lyne, V. (2024). TREATMENT OF LEISHMANIASIS. WO 2024/084186 A1

• Online Publication Date: Apr 25, 2024
• Publication Date: Apr 25, 2024
• Deposit Date: Apr 29, 2024
• Publicly Available Date: May 1, 2024
• Public URL: https://durham-repository.worktribe.com/output/2407649