Running rings around protein cages: a case study of artificial TRAP cages

Gaweł, Szymon; Naskalska, Antonina; Osiński, Norbert; Gardiner Heddle, Jonathan

Abstract

Proteins that constitute the capsids of viruses are well known for their ability to assemble into cage-like containers. Such containers can carry out useful tasks such as the delivery of cargoes to cells. Here we briefly review our work on naturally-occurring protein cages which were re-engineered to serve as containers. We focus on a completely artificial “TRAP-cage” and review its potential applications as a vaccine candidate and smart drug delivery system.

Citation

Gaweł, S., Naskalska, A., Osiński, N., & Gardiner Heddle, J. (2024). Running rings around protein cages: a case study of artificial TRAP cages. In M. Ryadnov, & K. Matsuura (Eds.), Amino Acids, Peptides and Proteins: Volume 45 (45-63). Royal Society of Chemistry. https://doi.org/10.1039/bk9781839169328-00045

• Online Publication Date: Feb 2, 2024
• Publication Date: Feb 2, 2024
• Deposit Date: Feb 9, 2024
• Publisher: Royal Society of Chemistry
• Pages: 45-63
• Book Title: Amino Acids, Peptides and Proteins: Volume 45
• ISBN: 9781839167058
• DOI: https://doi.org/10.1039/bk9781839169328-00045
• Public URL: https://durham-repository.worktribe.com/output/2231521