Amphiphilic Polyurethane with Cluster-Induced Emission for Multichannel Bioimaging in Living Cell Systems.

Jiang, Nan; Li, Ke-Xin; Wang, Jia-Jun; Zhu, You-Liang; Zhu, Chang-Yi; Xu, Yan-Hong; Bryce, Martin R

Abstract

The development of single-component materials with low cytotoxicity and multichannel fluorescence imaging capability is a research hotspot. In the present work, highly electron-deficient pyrazine monomers were covalently connected into a polyurethane backbone using addition polymerization with terminal poly(ethylene glycol) monomethyl ether units containing a high density of electron pairs. Thereby, an amphiphilic polyurethane-pyrazine ( ) derivative has been synthesized. The polymer displays cluster-induced emission through compact inter- and/or intramolecular noncovalent interactions and extensive through-space electron coupling and delocalization. Molecular rigidity facilitates red-shifted emission. Based on hydrophilic/hydrophobic interactions and excitation dependence emission at low concentrations, has been self-assembled into fluorescent nanoparticles ( NPs) without additional surfactant. NPs have been used for cellular multicolor imaging to provide a variety of switchable colors on demand. This work provides a simple molecular design for environmentally sustainable, luminescent materials with excellent photophysical properties, biocompatibility, low cytotoxicity, and color modulation.

Citation

Jiang, N., Li, K., Wang, J., Zhu, Y., Zhu, C., Xu, Y., & Bryce, M. R. (2024). Amphiphilic Polyurethane with Cluster-Induced Emission for Multichannel Bioimaging in Living Cell Systems. ACS Macro Letters, 13(1), 52-57. https://doi.org/10.1021/acsmacrolett.3c00657

• Journal Article Type: Article
• Acceptance Date: Dec 20, 2023
• Online Publication Date: Dec 26, 2023
• Publication Date: Jan 16, 2024
• Deposit Date: Mar 20, 2024
• Publicly Available Date: Mar 20, 2024
• Journal: ACS macro letters
• Publisher: American Chemical Society
• Peer Reviewed: Peer Reviewed
• Volume: 13
• Issue: 1
• Pages: 52-57
• DOI: https://doi.org/10.1021/acsmacrolett.3c00657
• Public URL: https://durham-repository.worktribe.com/output/2120215