Skip to main content

Research Repository

Advanced Search

Amphiphilic Polyurethane with Cluster-Induced Emission for Multichannel Bioimaging in Living Cell Systems.

Jiang, Nan; Li, Ke-Xin; Wang, Jia-Jun; Zhu, You-Liang; Zhu, Chang-Yi; Xu, Yan-Hong; Bryce, Martin R

Amphiphilic Polyurethane with Cluster-Induced Emission for Multichannel Bioimaging in Living Cell Systems. Thumbnail


Authors

Nan Jiang

Coco Li kexin.li2@durham.ac.uk
PGR Student Doctor of Philosophy

Jia-Jun Wang

You-Liang Zhu

Chang-Yi Zhu

Yan-Hong Xu



Abstract

The development of single-component materials with low cytotoxicity and multichannel fluorescence imaging capability is a research hotspot. In the present work, highly electron-deficient pyrazine monomers were covalently connected into a polyurethane backbone using addition polymerization with terminal poly(ethylene glycol) monomethyl ether units containing a high density of electron pairs. Thereby, an amphiphilic polyurethane-pyrazine ( ) derivative has been synthesized. The polymer displays cluster-induced emission through compact inter- and/or intramolecular noncovalent interactions and extensive through-space electron coupling and delocalization. Molecular rigidity facilitates red-shifted emission. Based on hydrophilic/hydrophobic interactions and excitation dependence emission at low concentrations, has been self-assembled into fluorescent nanoparticles ( NPs) without additional surfactant. NPs have been used for cellular multicolor imaging to provide a variety of switchable colors on demand. This work provides a simple molecular design for environmentally sustainable, luminescent materials with excellent photophysical properties, biocompatibility, low cytotoxicity, and color modulation.

Citation

Jiang, N., Li, K., Wang, J., Zhu, Y., Zhu, C., Xu, Y., & Bryce, M. R. (2024). Amphiphilic Polyurethane with Cluster-Induced Emission for Multichannel Bioimaging in Living Cell Systems. ACS Macro Letters, 13(1), 52-57. https://doi.org/10.1021/acsmacrolett.3c00657

Journal Article Type Article
Acceptance Date Dec 20, 2023
Online Publication Date Dec 26, 2023
Publication Date Jan 16, 2024
Deposit Date Mar 20, 2024
Publicly Available Date Mar 20, 2024
Journal ACS macro letters
Publisher American Chemical Society
Peer Reviewed Peer Reviewed
Volume 13
Issue 1
Pages 52-57
DOI https://doi.org/10.1021/acsmacrolett.3c00657
Public URL https://durham-repository.worktribe.com/output/2120215

Files




You might also like



Downloadable Citations