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A Scoping Review of the Effects of Ambient Air Quality on Cognitive Frailty

Hodgson, James Robert; Benkowitz, Charlotte; Castellani, Brian C; Ellison, Amanda; Yassaie, Rammina; Twohig, Helen; Bhudia, Roshni; Jutila, Otto-Emil Ilmari; Fowler-Davis, Sally

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Authors

James Robert Hodgson

Charlotte Benkowitz

Rammina Yassaie

Helen Twohig

Roshni Bhudia

Otto-Emil Ilmari Jutila

Sally Fowler-Davis



Abstract

Environmental and public health research has given considerable attention to the impact of air quality on brain health, with systematic reviews being widespread. No literature review has been conducted for cognitive frailty—a multidimensional syndrome combining physical frailty and cognitive impairment and their apparent co-dependence, linked to increased vulnerability and adverse health outcomes, including dementia. Instead, cognitive decline and frailty are implicitly explored through research on air quality and comorbid cognitive and physical decline in elderly populations. A scoping review was conducted to explore the need for a systematic review. Combining the Arksey and O’Malley, and PRISMA-ScR checklist, a scoping review of SCOPUS using ‘cogniti*’ + ‘resilience’ + ‘air quality’ or ‘cogniti*’ + ‘ageing’ + ‘air quality’ resulted in n = 2503 articles, screened and reduced using inclusion and exclusion criteria, to n = 16 articles. Air quality appears to be a critical risk factor for cognitive decline, even at air quality levels below WHO targets. Moderate long-term ambient air pollution appears linked to increased risk of cognitive frailty, suggesting earlier and more active interventions to protect older people. There are varied effects on cognition across the life course, with both emotional and functional impacts. Effects may be more detrimental to elderly people with existing conditions, including economic and health inequalities. Generalisation of results is limited due to the absence of a dose–response, variations in methods, controlling for comorbid effects, and variance across studies. No literature review has been performed for cognitive frailty, largely due to the fact that it is not presently treated as an explicit outcome. The findings support the need for more research and a more extensive summary of the literature but suggest that there is worsening cognitive function over the life course as a result of increased PM2.5 concentrations. Furthermore, air quality appears to be a critical risk factor even at levels below World Health Organisation targets.

Citation

Hodgson, J. R., Benkowitz, C., Castellani, B. C., Ellison, A., Yassaie, R., Twohig, H., …Fowler-Davis, S. (2024). A Scoping Review of the Effects of Ambient Air Quality on Cognitive Frailty. Environments, 11(1), Article 4. https://doi.org/10.3390/environments11010004

Journal Article Type Article
Acceptance Date Dec 15, 2023
Online Publication Date Dec 20, 2023
Publication Date 2024-01
Deposit Date Dec 20, 2023
Publicly Available Date Dec 21, 2023
Journal Environments
Publisher MDPI
Peer Reviewed Peer Reviewed
Volume 11
Issue 1
Article Number 4
DOI https://doi.org/10.3390/environments11010004
Keywords cognitive function, air pollution and brain health, cognitive frailty, ambient air quality, older adults
Public URL https://durham-repository.worktribe.com/output/2049118

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