Chelating chloride using binuclear lanthanide complexes in water

Alexander, Carlson; Thom, James A.; Kenwright, Alan M.; Christensen, Kirsten E.; Sørensen, Thomas Just; Faulkner, Stephen

Abstract

Halide recognition by supramolecular receptors and coordination complexes in water is a long-standing challenge. In this work, we report chloride binding in water and in competing media by pre-organised binuclear kinetically inert lanthanide complexes, bridged by flexible –(CH2)2– and –(CH2)3– spacers, forming [Ln2(DO3A)2C-2] and [Ln2(DO3A)2C-3], respectively. These hydrophilic, neutral lanthanide coordination complexes are shown to bind chloride with apparent association constants of up to 105 M−1 in water and in buffered systems. Hydroxide bridging was observed in these complexes at basic pH, which was proven to be overcome by chloride. Thus, these lanthanide complexes show promise towards chloride recognition in biology and beyond. The results described here have clearly identified a new area of anion coordination chemistry that is ripe for detailed exploration.

Citation

Alexander, C., Thom, J. A., Kenwright, A. M., Christensen, K. E., Sørensen, T. J., & Faulkner, S. (2023). Chelating chloride using binuclear lanthanide complexes in water. Chemical Science, 14(5), 1194-1204. https://doi.org/10.1039/d2sc05417e

• Journal Article Type: Article
• Acceptance Date: Dec 27, 2022
• Online Publication Date: Dec 27, 2022
• Publication Date: 2023
• Deposit Date: Nov 6, 2023
• Publicly Available Date: Nov 6, 2023
• Journal: Chemical Science
• Print ISSN: 2041-6520
• Electronic ISSN: 2041-6539
• Publisher: Royal Society of Chemistry
• Peer Reviewed: Peer Reviewed
• Volume: 14
• Issue: 5
• Pages: 1194-1204
• DOI: https://doi.org/10.1039/d2sc05417e
• Keywords: General Chemistry
• Public URL: https://durham-repository.worktribe.com/output/1898308