Understanding the mechanism by which Gd( iii ) coiled coils achieve magnetic resonance relaxivity – a study into the water coordination chemistry

Newton, S. L.; Franke, A.; Zahl, A.; Molinaro, G.; Kenwright, A.; Smith, D. J.; Ivanovic-Burmazovic, I.; Britton, M. M.; Peacock, A. F. A.

Abstract

A class of Gd(iii) coiled coils achieve high MRI relaxivity, in part due to their slow rotational correlation time. However, extending their length is unable to further enhance performance, as the mechanism by which relaxivity is achieved is dominated by the presence of three inner sphere waters in rapid exchange, through an associative mechanism.

Citation

Newton, S. L., Franke, A., Zahl, A., Molinaro, G., Kenwright, A., Smith, D. J., …Peacock, A. F. A. (2023). Understanding the mechanism by which Gd( iii ) coiled coils achieve magnetic resonance relaxivity – a study into the water coordination chemistry. Dalton Transactions, 43(52), 15665-15668. https://doi.org/10.1039/d3dt02909c

• Journal Article Type: Article
• Acceptance Date: Oct 23, 2023
• Online Publication Date: Oct 24, 2023
• Publication Date: Oct 24, 2023
• Deposit Date: Dec 20, 2023
• Publicly Available Date: Dec 20, 2023
• Journal: Dalton Transactions
• Print ISSN: 1477-9226
• Publisher: Royal Society of Chemistry
• Peer Reviewed: Peer Reviewed
• Volume: 43
• Issue: 52
• Pages: 15665-15668
• DOI: https://doi.org/10.1039/d3dt02909c
• Public URL: https://durham-repository.worktribe.com/output/1863142