Yanin Suwan
Parapapillary choroidal microvascular density in acute primary angle-closure and primary open-angle glaucoma: an optical coherence tomography angiography study
Suwan, Yanin; Aghsaei Fard, Masoud; Vilainerun, Nantinee; Petpiroon, Purit; Tantraworasin, Apichat; Teekhasaenee, Chaiwat; Ritch, Robert; Kafieh, Rahele; Hojati, Sahar; Supakontanasan, Wasu
Authors
Masoud Aghsaei Fard
Nantinee Vilainerun
Purit Petpiroon
Apichat Tantraworasin
Chaiwat Teekhasaenee
Robert Ritch
Dr Raheleh Kafieh raheleh.kafieh@durham.ac.uk
Assistant Professor
Sahar Hojati
Wasu Supakontanasan
Abstract
Back ground/aims To determine whether parapapillary choroidal microvasculature (PPCMv) density, measured by optical coherence tomography angiography, differed between acute primary angle-closure (APAC), primary open-angle glaucoma (POAG) and controls.
Methods This is a prospective, cross-sectional, observational study. Data from 149 eyes from two academic referral centres were analysed. Automated PPCMv density was calculated in inner and outer annuli around the optic nerve region in addition to the peripapillary superficial vasculature, using customised software. A generalised estimating equation was used to compare vessel densities among groups, adjusted for confounders.
Results Data from 40 eyes with APAC, 65 eyes with POAG and 44 eyes in healthy controls were gathered and analysed. Global radial peripapillary capillary densities were reduced in eyes with APAC and POAG compared with controls (p=0.027 and 0.136, respectively). Mean outer annular PPCMv density in the POAG group was lower vs the APAC group by 3.6% (95% CI 0.6% to 6.5%) (p=0.018) in the multivariable model adjusted for confounders. The mean difference in inner and outer superior PPCMv between the POAG and APAC groups was 5.9% and 4.4% (95% CI 1.9% to 9.9% and 1.0% to 7.7%, respectively; both p<0.010). Furthermore, POAG and APAC groups both had significantly lower PPCMv compared with controls (both, p<0.001).
Conclusions While superficial peripapillary vessels were affected to similar degrees in POAG and APAC, PPCMv drop-out was greater with POAG versus APAC, suggesting that choroidal vessel density may be affected to a lesser extent following an acute increase in intraocular pressure before glaucoma develops.
Citation
Suwan, Y., Aghsaei Fard, M., Vilainerun, N., Petpiroon, P., Tantraworasin, A., Teekhasaenee, C., Ritch, R., Kafieh, R., Hojati, S., & Supakontanasan, W. (2023). Parapapillary choroidal microvascular density in acute primary angle-closure and primary open-angle glaucoma: an optical coherence tomography angiography study. British Journal of Ophthalmology, 107(10), 1438-1443. https://doi.org/10.1136/bjo-2021-321022
Journal Article Type | Article |
---|---|
Acceptance Date | Jun 21, 2022 |
Online Publication Date | Jul 13, 2022 |
Publication Date | 2023-10 |
Deposit Date | Oct 26, 2023 |
Publicly Available Date | Oct 26, 2023 |
Journal | British Journal of Ophthalmology |
Print ISSN | 0007-1161 |
Electronic ISSN | 1468-2079 |
Publisher | BMJ Publishing Group |
Peer Reviewed | Peer Reviewed |
Volume | 107 |
Issue | 10 |
Pages | 1438-1443 |
DOI | https://doi.org/10.1136/bjo-2021-321022 |
Public URL | https://durham-repository.worktribe.com/output/1817987 |
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